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PhD topics for academic year 2021/2022

Study Programme:

Faculty of Chemical Engineering

Ab initio photodynamics in condensed phase: Method development and applications

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
Computational photodynamics is a fast evolving field. At present, we are able to simulate ultrafast porcesses in medium-sized molecules. This Thesis focuses on developement and applications of photodynamical methods describing light-induced processes in condensed phase. For more information, see http://photox.vscht.cz/
Faculty of Chemical Engineering

Ab initio simulations of structural, thermodynamic and transport properties of metalorganic frameworks

Červinka Ctirad, Ing. Ph. D. ( Cti...@vscht.cz)
Faculty of Chemical Engineering

Ab initio simulations of structural, thermodynamic and transport properties of metalorganic frameworks

Červinka Ctirad, Ing. Ph. D. ( Cti...@vscht.cz)
Faculty of Food and Biochemical Technology

Acid whey and the possibility of its further processing

Čurda Ladislav, doc. Ing. CSc. ( cur...@vscht.cz)
Acid whey is difficult treatable by-product of quark and some types of yogurt due to high content of salts and lactic acid. Electrodialysis in combination with other membrane and chromatographic processes is potentially applicable technology for valorisation of acid whey. The aim of thesis is to propose and to verify suitable configuration and conditions of acid whey processing. Application of electrodialysis with bipolar membranes is assumed too. Attention will be also focused on utilization of waste streams, from which could be isolated lactic acid or phosphates.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Technology

Advanced bactericidal coatings with long-lasting effect

Siegel Jakub, doc. Ing. Ph.D. ( Jak...@vscht.cz)
Experimental work focused on the optimization of immobilization of metal nanoparticles on polymeric supports for the preparation of a new generation of antimicrobial surfaces. Nanoparticle immobilization will be acomplished by physical methods based on the interaction of prepared particles with laser radiation. Antibacterial effects and biocompatibility of developed surfaces will be evaluated in cooperation with the Department of Biochemistry and Microbiology VŠCHT Prague.

Study Programme:

Faculty of Chemical Technology

Advanced composites based on magnesium oxychloride and layered nanomaterials

Jankovský Ondřej, Doc. Ing. Ph.D. ( Ond...@vscht.cz)
In this dissertation thesis, reactive magnesia-based composites will be prepared and characterized. The Sorel cement phase 5 (Mg3(OH)5Cl.H2O, MOC) will be used as a matrix and carbon-based layered nanomaterials (graphene, graphite oxide) will be used as an additive. Also, various types of alternative fillers will be used. All prepared samples will be characterized in terms of their phase and chemical composition, morphology and thermal behavior. The prepared macroscopic samples will be subjected to mechanical testing.
Faculty of Chemical Engineering

Advanced formulation approaches for topical delivery

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Zbytovská Jarmila, doc. Mgr. Dr.rer.nat. ( zby...@vscht.cz)
Although skin appears to be a macroscopically homogeneous and biologically passive structure, it is exactly the opposite: it is incredibly heterogeneous both chemically and structurally, and it is host to a diversity of active cells such as macrophages and bacteria. Traditional approaches to topical delivery have relied on relatively simple systems such as passive diffusion from water- or oil-based solutions or creams/gels. The aim of this project is to investigate bioactive transport as a mechanism for topical delivery and find a solution to such molecules as therapeutic peptides, which are known to be extremely challenging to formulate and delivery to the body. This project will explore the use of drug delivery systems that are actively phagocytised for targeting macrophages residing in the skin. These drug delivery systems will include naturally sourced polysaccharide shells or lipidic vesicles obtained from single-cell organisms. Their mild immunogenicity, biocompatibility and ability to encapsulate a broad range of molecules will be utilized for the formulation of APIs that have proven to be challenging by traditional means.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

Advanced formulation approaches for topical delivery

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Zbytovská Jarmila, doc. Mgr. Dr.rer.nat. ( zby...@vscht.cz)
Although skin appears to be a macroscopically homogeneous and biologically passive structure, it is exactly the opposite: it is incredibly heterogeneous both chemically and structurally, and it is host to a diversity of active cells such as macrophages and bacteria. Traditional approaches to topical delivery have relied on relatively simple systems such as passive diffusion from water- or oil-based solutions or creams/gels. The aim of this project is to investigate bioactive transport as a mechanism for topical delivery and find a solution to such molecules as therapeutic peptides, which are known to be extremely challenging to formulate and delivery to the body. This project will explore the use of drug delivery systems that are actively phagocytised for targeting macrophages residing in the skin. These drug delivery systems will include naturally sourced polysaccharide shells or lipidic vesicles obtained from single-cell organisms. Their mild immunogenicity, biocompatibility and ability to encapsulate a broad range of molecules will be utilized for the formulation of APIs that have proven to be challenging by traditional means.

Study Programme:

Faculty of Chemical Technology

Advanced high-entropy alloys with modifiable properties

Průša Filip, Ing. Ph.D. ( Fil...@vscht.cz)
High entropy alloys belong to a relatively new group of materials which are characterized by the preferential formation of solid solutions instead of intermetallic compounds. These materials exhibit several excellent properties, foremostly high strengths while maintaining sufficient ductility, good corrosion resistance and others. By suitable processing of these alloys, it is possible to achieve further substantial improvement of these already very good properties. The work will be focused on the preparation of new advanced high-entropy alloys combining significantly higher strengths while maintaining sufficient plasticity.
Faculty of Chemical Technology

Advanced materials for green hydrogen preparation

Švorčík Václav, prof. Ing. DrSc. ( svo...@vscht.cz)
Faculty of Chemical Technology

Advanced methods and applications of SERS

Lyutakov Oleksiy, Mgr. Ph.D. ( ole...@vscht.cz)
Faculty of Chemical Engineering

Advanced Methods of Adaptive Filtering for Novelty Detection

Mareš Jan, doc. Ing. Ph.D. ( mar...@vscht.cz)
Vrba Jan, Ing. ( Jan...@vscht.cz)
The topic of the work is focused on the development and implementation of the methodology of so-called novelty detection in process data. The project is based on the analysis of selected real (complex) process data. The work assumes (i) study of advanced methods of signal analysis, (ii) design of specific methods and algorithms for adaptive data filtering and novelty detection using the Extrem Seeking Entropy method (iii) implementation and verification.
Faculty of Chemical Engineering

Advanced Methods of Adaptive Filtering for Novelty Detection

Mareš Jan, doc. Ing. Ph.D. ( mar...@vscht.cz)
Vrba Jan, Ing. ( Jan...@vscht.cz)
The topic of the work is focused on the development and implementation of the methodology of so-called novelty detection in process data. The project is based on the analysis of selected real (complex) process data. The work assumes (i) study of advanced methods of signal analysis, (ii) design of specific methods and algorithms for adaptive data filtering and novelty detection using the Extrem Seeking Entropy method (iii) implementation and verification.
Faculty of Chemical Engineering

Advanced methods of facial data analysis for the evaluation of the rehabilitation process

Mareš Jan, doc. Ing. Ph.D. ( mar...@vscht.cz)
Analysis of biomedical data is currently in great demand, but at the same time quite a difficult task. The project is based on cooperation with the University Hospital Královské Vinohrady and is focused on capturing 3D facial data of patients after depth surgery and analysis of this data. The work assumes (i) the study of advanced methods of image analysis, (ii) the design of a specific methodology and algorithm for data acquisition using various HW tools: Kinect, mobile phone, etc.), (iii) processing of these biomedical data and (iv) implementation and verification in a hospital environment.
Faculty of Chemical Engineering

Advanced methods of facial data analysis for the evaluation of the rehabilitation process

Mareš Jan, doc. Ing. Ph.D. ( mar...@vscht.cz)
Analysis of biomedical data is currently in great demand, but at the same time quite a difficult task. The project is based on cooperation with the University Hospital Královské Vinohrady and is focused on capturing 3D facial data of patients after depth surgery and analysis of this data. The work assumes (i) the study of advanced methods of image analysis, (ii) the design of a specific methodology and algorithm for data acquisition using various HW tools: Kinect, mobile phone, etc.), (iii) processing of these biomedical data and (iv) implementation and verification in a hospital environment.
Faculty of Chemical Engineering

Advanced Signal Processing Methods in Development of Virtual Control Board

Mareš Jan, doc. Ing. Ph.D. ( mar...@vscht.cz)
The project is devoted to design of virtual control board of selected real technological process. The work is based on analysis of selected biomedical data, 3D modelling and virtual reality. The project assumes (i) study of advanced methods of biomedical signal analysis and 3D modelling (ii) the proposal of specific algorithms for virtualisation, 3D modelling and process control, (iii) implementation and verification.
Faculty of Chemical Engineering

Advanced Signal Processing Methods in Development of Virtual Control Board

Mareš Jan, doc. Ing. Ph.D. ( mar...@vscht.cz)
The project is devoted to design of virtual control board of selected real technological process. The work is based on analysis of selected biomedical data, 3D modelling and virtual reality. The project assumes (i) study of advanced methods of biomedical signal analysis and 3D modelling (ii) the proposal of specific algorithms for virtualisation, 3D modelling and process control, (iii) implementation and verification.
Faculty of Chemical Engineering

Advanced statistical methods and their application on biomedical data

Kříž Pavel, Mgr. Ing. Ph.D. ( k...@vscht.cz)
Biomedical data often show very complex structure (many correlated variables, autocorrelation in time and/or space, high-dimensional data, high-frequency data etc.). Its correct statistical analysis is not a routine, it requires creativity in combination with use of various advanced statistical methods and techniques. The objective of this work is to explore and study advanced methods from different fields of statistics (such as multivariate statistics, time series analysis, functional data analysis etc.) and design their appropriate combinations (or develop their modifications) in order to extract important and useful information from selected biomedical data. Emphasis is put on rigorous approach to assumption verification and results interpretation (incl. assessment of their reliability using exact of simulation techniques).
Faculty of Chemical Technology

Advanced structures and materials for surface enhanced Raman spectroscopy

Švorčík Václav, prof. Ing. DrSc. ( svo...@vscht.cz)
Faculty of Chemical Technology

Analysis of batch-to-glass conversion process

Pokorný Richard, Ing. Ph.D. ( pok...@vscht.cz)
The goal of this project targets the analysis of one of the critical batch-to-glass conversion processes – the evolution and collapse of the primary foam at the batch-melt interface. This porous foam layer, which behaves as a form of insulation layer, results from the products of various gas evolving reactions that are being trapped in the primary melt. This project will focus on understanding the foam morphology, the reactions that lead to primary foaming.
Faculty of Chemical Technology

Analysis of batch-to-glass conversion process

Pokorný Richard, Ing. Ph.D. ( pok...@vscht.cz)
The goal of this project targets the analysis of one of the critical batch-to-glass conversion processes – the evolution and collapse of the primary foam at the batch-melt interface. This porous foam layer, which behaves as a form of insulation layer, results from the products of various gas evolving reactions that are being trapped in the primary melt. This project will focus on understanding the foam morphology, the reactions that lead to primary foaming.
Faculty of Chemical Technology

Analysis of damage causes of historical objects

Michalcová Alena, doc. Ing. Ph.D. ( Ale...@vscht.cz)
Msallamová Šárka, Ing. Ph.D. ( msa...@vscht.cz)
The damage causes of historical objects are not always easy to identify. When the damage is caused by microscopic changes in the materials microstructure, it is necessary to use advance analytical techniques, e.g. transmission electron microscopy. In this work, the results obtained from historical materials will be compared with model samples.
Faculty of Environmental Technology

Analysis of fuel additives and determination of their content in motor fuels

Šimáček Pavel, doc. Ing. Ph.D. ( sim...@vscht.cz)
Motor fuels often contain low concentrations of special fuel additives, which improve their properties. The additives can be commonly added to motor fuels during their production, but they can be also added to motor fuels after basic refinery fuel formulation, mostly in form of additive packages present in premium motor fuels. There are also retail additive packages designed for fuel treatment directly in the fuel tanks of vehicles. The scope of the work is development and optimization of analytical methods designed for fuel additives, for their identification and determination of their content in motor fuels.
Faculty of Food and Biochemical Technology

Analysis of multispecies biofilms of food-borne pathogenic bacteria

Demnerová Kateřina, prof. Ing. CSc. ( dem...@vscht.cz)
Zdeňková Kamila, Ing. Ph.D. ( zde...@vscht.cz)
Most bacteria, due to their phenotypic adaptability, can live in a community called biofilm, which is often multi-species. Biofilm serves for their adherence, communication, protection and increases the resistance of bacteria to adverse environmental conditions. Its characteristic persistence, heterogeneity and complex dynamics are related to relatively difficult detection and problematic analyses by classical microbial methods. That is why such consortia are nowadays a challenge for many professionals. Multi-species biofilms of Listeria monocytogenes, Staphylococcus aureus and Escherichia coli, will be analysed during the course of the dissertation as selected representatives of food pathogens monitored under Commission Regulation (EC) 2073/2005. Classical microbiological and modern molecular-biological methods will be used. The multi-species biofilm study will also include analyses of gene expression levels and impact on biofilms of antibiotics or other selected antimicrobials. This will contribute to a better understanding of the spread of resistance in the environment assisted by these communities, while at the same time increasing the existing knowledge about the coexistence of the biofilms of bacteria whose eradication from undesirable sites is more complicated than single-species biofilms.
Faculty of Food and Biochemical Technology

Analysis of volatile profiles for assessing the quality and safety of processed foods

Čížková Helena, doc. Ing. Ph.D. ( hel...@vscht.cz)
Gas chromatography with mass spectrometric detection in various configurations (one-dimensional, chiral, multidimensional, with olfactometry) will be used to analyse volatile profiles of various raw materials and processed foods. The aim of the thesis will be the evaluation of quality, detection of microbial contamination and identification of causes of sensory defects. The results of targeted and non-targeted analyses obtained by GC / MS will be correlated with the outputs of other laboratory methods (chromatographic, microbiological and sensory analysis). Advanced statistical methods will be used to interpret the results of analyses, considering the influence of raw materials, recipe, production and storage conditions. The project will be supported by National Agency for Agricultural Research and will be in cooperation with selected food producers.
Faculty of Food and Biochemical Technology

Anammox bacteria and their unique phospholipids

Lipovová Petra, doc. Ing. Ph.D. ( kar...@vscht.cz)
Anammox (anaerobic ammonium oxidation) bacteria, which were discovered relatively recently, play an important role in the global nitrogen cycle, thanks to their unique metabolism, the conversion of ammonium cation (NH4+) and nitrite (NO2-) to nitrogen. In this way, up to 50 % of ocean nitrogen is produced in oxygen-restricted zones. Currently, these microorganisms are used in wastewater treatment as ideal substitutes for the denitrification process. The sequence of reactions of anammox metabolism takes place on the membrane of a special compartment inside these bacteria called the anammoxosome. All membranes of anammox bacteria, including the anammoxosome, are composed of unique ladderan lipids. These are phospholipids which contained 5 cyclobutanes or a combination of 3 cyclobutanes with cyclohexane at the end of the acyl chain. Thanks to these unique lipids, the membrane of the anammoxosome transmits protons up to ten times slower than the classical bilayer of phospholipids, which helps maintain the proton-motive power of these bacteria. Not much is known about the synthesis of these special phospholipids. The aim of this work will be to contribute to the detection of enzymes involved in the synthesis and degradation of these phospholipids in anammox bacteria.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Technology

A new generation of materials and approaches for detecting and destroying of pharmaceutical contaminants in the aquatic environment

Lyutakov Oleksiy, Mgr. Ph.D. ( ole...@vscht.cz)

Study Programme:

Faculty of Chemical Technology

Anorganic-polymer microrobots for drug delivery

Pumera Martin, doc. RNDr. Ph.D. ( pum...@vscht.cz)
Faculty of Chemical Engineering

Application of data mining methods for monitoring and control of biotechnological processes

Hrnčiřík Pavel, doc. Ing. Ph.D. ( hrn...@vscht.cz)
In the research of biotechnological processes, experimental data of various structure and quality are generated. However, this highly heterogeneous data contains important information about the properties of these processes. This work is focused on the study and application of selected methods in the field of artificial intelligence and machine learning in the processing of this data. The acquired knowledge will then be used for advanced monitoring and control of the selected model biotechnological process.

Faculty of Chemical Engineering

Application of data mining methods for monitoring and control of biotechnological processes

Hrnčiřík Pavel, doc. Ing. Ph.D. ( hrn...@vscht.cz)
In the research of biotechnological processes, experimental data of various structure and quality are generated. However, this highly heterogeneous data contains important information about the properties of these processes. This work is focused on the study and application of selected methods in the field of artificial intelligence and machine learning in the processing of this data. The acquired knowledge will then be used for advanced monitoring and control of the selected model biotechnological process.

Faculty of Food and Biochemical Technology

Application of membrane processes for modification of functional properties of whey proteins.

Štětina Jiří, doc. Ing. CSc. ( ste...@vscht.cz)

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Technology

Application of milling and co-milling processes to formulation of poorly soluble drugs

Zámostný Petr, prof. Ing. Ph.D. ( zam...@vscht.cz)
Poorly soluble drugs (BCS II and IV classes) represent an important segment of marketed drugs. Improving solubility or at least the drug release kinetics is therefore a continuing challenge, which is approached by many ways on several levels. The milling, nano-milling, and/or co-milling processes of a drug with optional other excipients provide a way how to change the phase composition of the drug, increase the specific surface of drug particles, modify that surface, and also form composite particles. This study should be aimed at the options and possibilities of improving the drug release by all the above mechanisms, especially those related to particle technology. The study should involve both the preparation of particles and their formulation into suitable dosage forms and seek optimized approaches bringing the best performance while complying with the requirements of industrial manufacturability of the formulation.
Faculty of Chemical Technology

Application of milling and co-milling processes to formulation of poorly soluble drugs

Zámostný Petr, prof. Ing. Ph.D. ( zam...@vscht.cz)
Poorly soluble drugs (BCS II and IV classes) represent an important segment of marketed drugs. Improving solubility or at least the drug release kinetics is therefore a continuing challenge, which is approached by many ways on several levels. The milling, nano-milling, and/or co-milling processes of a drug with optional other excipients provide a way how to change the phase composition of the drug, increase the specific surface of drug particles, modify that surface, and also form composite particles. This study should be aimed at the options and possibilities of improving the drug release by all the above mechanisms, especially those related to particle technology. The study should involve both the preparation of particles and their formulation into suitable dosage forms and seek optimized approaches bringing the best performance while complying with the requirements of industrial manufacturability of the formulation.

Study Programme:

Faculty of Chemical Engineering

Application of molecular modelling in the screening and characterization of new solid forms of drug substances

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Heyda Jan, RNDr. Mgr. Ph.D. ( jan...@vscht.cz)
Experimental screening of new solid forms of drug substances, i.e. polymorphs, salts, co-crystals or solvates, is very labor process requiring of testing various conditions. Once the new solid form is discovered it is analyzed by a combination of several techniques including XRD, NMR, Raman spectroscopy, SEM, DSC, solubility and stability. In this project we plan to utilize molecular simulations to support experimental screening procedure. This will increase our fundamental understanding of involved interactions between drug and excipient molecules. In particular, we plan to use molecular modelling in the calculation of the interaction energies of prepared drug solid form to rank relative thermodynamic stability and melting temperature. When possible, molecular dynamics simulation will be benchmarked to experimentally measured properties of drug solid forms, i.e. XRD data, or to interactions determined by NMR or FTIR. In the last part, we plan to apply molecular modelling in the description of solubility of newly discovered solid forms in the presence of various excipients (i.e. surfactants, polymers, partner molecules) in water media.
Faculty of Chemical Engineering

Application of molecular modelling in the screening and characterization of new solid forms of drug substances

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Heyda Jan, RNDr. Mgr. Ph.D. ( jan...@vscht.cz)
Experimental screening of new solid forms of drug substances, i.e. polymorphs, salts, co-crystals or solvates, is very labor process requiring of testing various conditions. Once the new solid form is discovered it is analyzed by a combination of several techniques including XRD, NMR, Raman spectroscopy, SEM, DSC, solubility and stability. In this project we plan to utilize molecular simulations to support experimental screening procedure. This will increase our fundamental understanding of involved interactions between drug and excipient molecules. In particular, we plan to use molecular modelling in the calculation of the interaction energies of prepared drug solid form to rank relative thermodynamic stability and melting temperature. When possible, molecular dynamics simulation will be benchmarked to experimentally measured properties of drug solid forms, i.e. XRD data, or to interactions determined by NMR or FTIR. In the last part, we plan to apply molecular modelling in the description of solubility of newly discovered solid forms in the presence of various excipients (i.e. surfactants, polymers, partner molecules) in water media.
Faculty of Chemical Engineering

Application of non-thermal plasma in agriculture

Scholtz Vladimír, doc. Ing. Ph.D. ( sch...@vscht.cz)
Jirešová Jana, Dr. Mgr. ( jir...@vscht.cz)
The application of non-thermal plasma in agriculture, especially for the treatment of seeds and young plants, is a new and developing area of scientific research. Plasma has beneficial effects on plant germination, their initial growth as well as the overall yield of production. The work is focused mainly on corona discharges and their perspective for breaking the dormancy of seeds of selected plants and the study of influencing their germination and growth. There is a place also for the study of the effect of the bactericidal agent of plasma on various types of bacteria, their spores, yeasts, fungi and other microorganisms found on the surface of seeds or other plant products.
Faculty of Chemical Engineering

Application of spatial analysis methods for forensic sciences

Hrnčiřík Pavel, doc. Ing. Ph.D. ( hrn...@vscht.cz)
Most of the data processed within the forensic sciences also includes a spatial component indicating the position of the described objects (eg GPS data). An important part of computer processing of this type of data thus includes the application of advanced methods of spatial analysis to determine selected contexts contained in the data. This work is specifically focused on advanced data processing and analysis describing the findings of various types of projectiles in the investigated terrain.
Faculty of Chemical Engineering

Application of spatial analysis methods for forensic sciences

Hrnčiřík Pavel, doc. Ing. Ph.D. ( hrn...@vscht.cz)
Most of the data processed within the forensic sciences also includes a spatial component indicating the position of the described objects (eg GPS data). An important part of computer processing of this type of data thus includes the application of advanced methods of spatial analysis to determine selected contexts contained in the data. This work is specifically focused on advanced data processing and analysis describing the findings of various types of projectiles in the investigated terrain.
Faculty of Chemical Engineering

Applications of the non-thermal plasma microbicidal effects

Scholtz Vladimír, doc. Ing. Ph.D. ( sch...@vscht.cz)
Non-thermal plasma seems to be a possible alternative to the common disinfection and sterilization methods. Scope of this work are the corona discharges and their possible practical applications for the decontamination of surfaces and liquids and as a therapeutic method in medicine. Moreover, this work covers also the investigation of microbicidal effects of corona discharges to the bacteria, bacterial spores, yeast, fungi and other microorganisms.
Faculty of Food and Biochemical Technology

Assessing of minor plant raw materials quality

Rajchl Aleš, doc. Ing. Ph.D. ( ale...@vscht.cz)
Čížková Helena, doc. Ing. Ph.D. ( hel...@vscht.cz)
Minor plant raw materials are often neglected, due to low production volume, and sufficient attention is not paid to their quality. The aim of this work is to assess the quality of selected minor raw materials of plant origin. The work will be also focused on development of new analytical methods for evaluating the quality of studied materials.
Faculty of Food and Biochemical Technology

Assessing of minor plant raw materials quality

Rajchl Aleš, doc. Ing. Ph.D. ( ale...@vscht.cz)
Čížková Helena, doc. Ing. Ph.D. ( hel...@vscht.cz)
Minor plant raw materials are often neglected, due to low production volume, and sufficient attention is not paid to their quality. The aim of this work is to assess the quality of selected minor raw materials of plant origin. The work will be also focused on development of new analytical methods for evaluating the quality of studied materials.
Faculty of Chemical Engineering

Automated study of photochemical mechanisms

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The thesis will focus on mechanisms of organic reactions in both the ground and excited states. Ab initio techniques and methods of ab initio molecular dynamics will be used. It is anticipated that new computational techniques will be developed, in attempt to automatize the search for key aspects of reaction mechanisms.
Faculty of Chemical Engineering

Automated study of photochemical mechanisms

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The thesis will focus on mechanisms of organic reactions in both the ground and excited states. Ab initio techniques and methods of ab initio molecular dynamics will be used. It is anticipated that new computational techniques will be developed, in attempt to automatize the search for key aspects of reaction mechanisms.
Faculty of Food and Biochemical Technology

Bacterial L-asparaginases with therapeutical and biotechnological potential

Lipovová Petra, doc. Ing. Ph.D. ( kar...@vscht.cz)
Benešová Eva, Ing. Ph.D. ( Eva...@vscht.cz)
L-Asparaginases belong to enzymes with therapeutical and biotechnological potential. They are used in the treatment of acute lymphoblastic leukemia and also for the reduction of the content of toxic acrylamide in food. The antitumor activity of L-asparagineses results from the fact that some tumor cells are unable to synthesize L-asparagine and must therefore receive it from their environment. The effective reduction of its concentration in their surroundings by the action of L-asparaginases therefore results in the termination of preteosynthesis and other related processes and finelly in the death of tumor cells. L-Asparaginases originating from Escherichia coli and Dickeya dadantii are currently used in the clinical practice. However, their application is accompanied by a number of side effects, and for this reason there is an effort to find new enzymes suitable for clinical use and with minimal side effects. The aim of this work is therefore to identify new bacterial producers of L-asparaginases with suitable characteristics for therapeutic use. Particular attention will be paid to organisms whose enzyme equipment has not yet been characterized in detail, such as marine or cold-adapted bacteria.
Faculty of Chemical Engineering

Benchmarking classical and quantum-mechanical molecular simulations for predictions of phase equilibria

Červinka Ctirad, Ing. Ph. D. ( Cti...@vscht.cz)
Faculty of Chemical Engineering

Benchmarking classical and quantum-mechanical molecular simulations for predictions of phase equilibria

Červinka Ctirad, Ing. Ph. D. ( Cti...@vscht.cz)
Faculty of Chemical Engineering

Benchmarking the ab initio methods for polymorph stability ranking for molecular crystals

Červinka Ctirad, Ing. Ph. D. ( Cti...@vscht.cz)
Faculty of Chemical Engineering

Benchmarking the ab initio methods for polymorph stability ranking for molecular crystals

Červinka Ctirad, Ing. Ph. D. ( Cti...@vscht.cz)
Faculty of Chemical Technology

Bioaccesibility of antimony in urban traffic-loaded areas

Doušová Barbora, doc. Ing. CSc. ( dou...@vscht.cz)
Antimony (Sb) has not been well known and widely cited toxic elements yet, but it can posed a serious environmental risk in future. Sb compounds are used in industrial sphere as fire-resistant agents, hence the increased Sb concentration represents a challenge for geochemical and material research. The aim of this work is to study the stability of Sb compounds incoming to the environment and their subsequent behaviour in the soil-groundwater-surface water system. Geochemical properties of antimony and arsenic will be compared in term of their environmental stability and bioaccesibility. Next part of the work will be focused on the monitoring of selected heavily contaminated locality.
Faculty of Chemical Technology

Biodegradable bone cements

Malinová Lenka, Ing. Ph.D. ( len...@vscht.cz)
The work will be focused on the preparation of biodegradable polymeric bone cements, which could be used as temporary fillings for bone defects, which would be gradually replaced by bone tissue. Part of the work will be deal with the synthesis and modification of bone cements based on poly(propylene fumarate), which can be crosslinked in situ through its fumarate double bonds. The crosslinkability of the prepared materials, their mechanical properties, degradation rate and biocompatibility will be tested. The next part of the work will be focused on the possibility of filling bone cements with antibiotics or supportive fillers for bone growth and their effect on mechanical properties and degradation.
Faculty of Food and Biochemical Technology

Biologically active compounds in Cannabis sativa and other natural resources

Hajšlová Jana, prof. Ing. CSc. ( haj...@vscht.cz)
Fenclová Marie, Ing. Ph.D. ( fen...@vscht.cz)
The doctoral thesis will focus on the effective isolation, purification, and analytical characterization of biologically active secondary metabolites, including minor ones, contained in Cannabis sativa plants and other plant sources using modern instrumental technologies. Within the interdisciplinary cooperation, biological activity will also be evaluated. The acquired knowledge will be reflected in the design of new products such as cosmetics or food supplements.
Faculty of Food and Biochemical Technology

Biologically active compounds of plants and their changes during processing and storage

Schulzová Věra, doc. Dr. Ing. ( sch...@vscht.cz)
Plant biologically active compounds can have positive as well as negative effects on the human body. Levels of plant secondary metabolites depend on the type of plant or the growing conditions, but are also affected by processing and storage conditions Modern analytical methods, based mainly on the technique of ultra-performance liquid chromatography coupled with high resolution mass spectrometry detection, are applied for monitoring these compound levels and the assessment of individual compounds stability. For the assessment of the authenticity of vegetable raw materials, metabolomic fingerprinting / profiling technique with application of sophisticated statistical methods for the evaluation of obtained data is applied.
Faculty of Food and Biochemical Technology

Biologically active compounds of plants and their changes during processing and storage

Schulzová Věra, doc. Dr. Ing. ( sch...@vscht.cz)
Plant biologically active compounds can have positive as well as negative effects on the human body. Levels of plant secondary metabolites depend on the type of plant or the growing conditions, but are also affected by processing and storage conditions Modern analytical methods, based mainly on the technique of ultra-performance liquid chromatography coupled with high resolution mass spectrometry detection, are applied for monitoring these compound levels and the assessment of individual compounds stability. For the assessment of the authenticity of vegetable raw materials, metabolomic fingerprinting / profiling technique with application of sophisticated statistical methods for the evaluation of obtained data is applied.
Faculty of Food and Biochemical Technology

Biologically active substances in hops; their effects and uses

Dostálek Pavel, prof. Ing. CSc. ( Pav...@vscht.cz)
Jelínek Lukáš, Ing. Ph.D. ( Luk...@vscht.cz)
In the Czech Republic, some hops varieties have been bred for non-brewing purposes, mainly pharmaceutical. These varieties have high contents of prenylflavonoids (xanthohumol and desmethylxanthohumol). Desmethylxanthohumol is a precursor of 8-prenylnaringenin, which is the strongest known phytoestrogen. Demethylation of isoxanthohumol can also yield extracts with high levels of 8-prenylnaringenin. The goal of this work will be to determine the concentration of these substances in hops, test their biological effects, and develop methods for preparing extracts with enhanced levels of these substances for use as food supplements.
Faculty of Food and Biochemical Technology

Biologically active wound dressings based on natural and modified polysaccharides

Sinica Andrej, doc. Mgr. Ph.D. ( sin...@vscht.cz)
Bleha Roman, Ing. Ph.D. ( ble...@vscht.cz)
This dissertation is focused on the preparation of bioactive wound dressings based on de novo isolated and/or chemically modified polysaccharides. These polysaccharide materials will be enriched with selected biologically active compounds. The wound dressings experiments will be planned in order to obtain the most comprehensive information of their physicochemical, thermal and mechanical properties and biological activities, which will be tested in collaboration with will be tested in cooperation with the Department of Biochemistry and Microbiology at University of Chemistry and Technology Prague.
Faculty of Chemical Engineering

Bioreactors Design Parameters - Experimental study of transport characteristics in various apparatuses

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
Zedníková Mária, Ing. Ph.D. ( zed...@vscht.cz)
The efficiency of new biotechnology and pharmaceutical products manufacture also depends on a suitable bioreactor selection. In the design of an optimal bioreactor, they key parameters are the maximum yield of a primary product and, simultaneously, the lifetime of the used microorganisms. The aim of the doctoral study is to compare the design parameters (transport characteristics such as volumetric mass transfer coefficient, gas hold-up and energy dissipation intensity) of three types of the most commonly used bioreactors. The results will be used to characterize the differences and similarities of specific types of bioreactors in terms of gas distribution, mass transfer and mixing depending on the total energy supplied to the system. Transport characteristics will be obtained experimentally for model batches, which will be designed based on physical properties of real broths.
The work is intended as the cooperation of UCT Prague (supervisor's workplace) with ICPF Prague (consultant's workplace) and appropriatley complements the second PhD topic offered by the consultant. Both cooperating workplaces are equipped by necessary facilities i) mechanically stirred reactor, ii) bubble column and iii) air-lift reactor. All bioreactors are adapted to measure transport characteristics by the same methods, therefore the results will be comparable.
Requirements for an applicant: master degree in chemical or mechanical engineering, organic technology, biotechnology etc.; ability for teamwork; systematic and creative approach to scientific problems; interest in experimental work
Development principles: 1. Prostudovat odbornou literaturu na téma hydrodynamika a přenos hmoty v mechanicky míchaných nádobách, probublávaných kolonách a air-lift reaktorech.
2. Osvojit si techniky měření transportních charakteristik (parametry charakterizující promíchávání v bioreaktorech, objemový koeficient přestupu hmoty, zádrž plynu aj.).
3. Provést systematická měření transportních charakteristik v různých modelových vsádkách a ve třech typech bioreaktorů: mechanicky míchaný reaktor, probublávaná kolona a air-lift reaktor.
4. Na základě získaných výsledků porovnat jednotlivé typy reaktorů, charakterizovat společné i rozdílné vlastnosti a vyhodnotit vhodnost jejich použití.
Faculty of Chemical Engineering

Black metals as active layers of chemiresistors

Vrňata Martin, prof. Ing. Dr. ( vrn...@vscht.cz)
Fitl Přemysl, Ing. Ph.D. ( f...@vscht.cz)
Metals of highly porous surface are called black metals (BM). Their chemical (oxidizability), mechanical (low density), electrical (higher resistivity) and optical (low reflectivity) properties originate from a unique combination of nanostructural and microstructural features of metalic materials. Regarding the applicability of BMs in chemiresistors, following properties are beneficial: (i) there is a large portion of surface atoms, which promotes interaction of BMs with gaseous species; (ii) the surface of BMs exhibits catalytic activity - it enables decomposition of larger analyte molecules into easily detectable reactive fragments; (iii) the surface of BMs is easily oxidizable to form core-shell metal-metal oxide structures with Schottky junction; (iv) the active layers based on BMs provide possibility to measure the response with high-frequency ac-signal leading to the so-called skin-effect, which is an effective tool to investigate only "surface" detection and compare the results with "volume" detection obtained with dc-signal.
Faculty of Chemical Engineering

Cahn-Hilliard Models for Evolution of Material Morphology

Kosek Juraj, prof. Dr. Ing. ( Jur...@vscht.cz)
Zubov Alexandr, Ing. Ph.D. ( Ale...@vscht.cz)
The development of new materials for applications in catalysis, construction, cars and local energy storage is the actual area of research. This development is mostly empirical. The objective of this project is the classification of knowledge about the evolution of material structure, the formulation of relevant physico-chemical models and their solution with the goal of obtaining general knowledge. Cahn-Hilliard models constitute one of the general approaches for the simulation of morphology evolution and they are applicable especially for the spinodal decomposition.

For practical and more general applicability of these models we have to develop thoroughly validated models extended about: (i) coupling with CFD simulations and behavior of liquid phase(s), (ii) advanced thermodynamics, (iii) considering the molecular architecture of polymers, (iv) models of transport coefficients dependent on local concentration, temperature and viscosity, (v) advanced description of phase interfaces, (vi) generalized Maxwell-Stefan transport, and (vii) generalization for self-consistent description of problems involving nucleation. Advanced Cahn-Hilliard models will be applied for: (i) morphology optimization of nano-/micro-cellular polymers with the goal of improved application properties, (ii) nucleation and coalescence of bubbles in early stages of foam evolution, (iii) evolution of particle morphology in emulsion copolymerizations, and (iv) evolution of salami morphology of high-impact polystyrene during its continuous manufacturing.

Prospective PhD student will not only improve his/her skills in modeling and visualization of spatially 3D problems, but will also penetrate deeply into physico-chemical nature of studied problems. PhD students will continue the development of modeling tools available in the research group. This project shall be sponsored by EU project H2020, grants and by industrial collaborations. PhD student shall spent part of the study at a foreign institution.

Info: phone 220 44 3296, office B-145, e-mailjkk@vscht.cz, webhttp://kosekgroup.cz
Faculty of Chemical Technology

Calixarene analogues containing pyridine rings

Lhoták Pavel, prof. Ing. CSc. ( lho...@vscht.cz)
Design and synthesis of novel macrocyclic systems based on calixarene analogues, containing pyridine moieties within the skeleton. The study of their chemical behaviour, basic chemical transformations, and conformational preferences. The application of these novel macrocyclic systems in the design of novel receptors for the recognition of anions and/or neutral molecules (e.g. fullerenes).
Faculty of Chemical Technology

Calixarene analogues containing pyridine rings

Lhoták Pavel, prof. Ing. CSc. ( lho...@vscht.cz)
Design and synthesis of novel macrocyclic systems based on calixarene analogues, containing pyridine moieties within the skeleton. The study of their chemical behaviour, basic chemical transformations, and conformational preferences. The application of these novel macrocyclic systems in the design of novel receptors for the recognition of anions and/or neutral molecules (e.g. fullerenes).
Faculty of Food and Biochemical Technology

Capsid lattice formation of RNA viruses

Rumlová Michaela, doc. Dr. Ing. ( Mic...@vscht.cz)
Faculty of Chemical Technology

Carbohydrate-based ligands for lectin targeting

Ménová Petra, Ing. Ph.D. ( pet...@vscht.cz)
Mammalian carbohydrate receptors (lectins) are involved in a number of vital processes, including pathogen recognition, uptake and processing, cell communication and cell migration.
Targeted delivery of therapeutic nucleic acids to hepatocytes is an attractive strategy for the treatment of hepatitis B and prevention of hepatocellular carcinoma. The almost exclusive presence of the lectin asialoglycoprotein receptor (ASGPR) makes it an ideal gateway for hepatocyte-targeted therapy.
DC-SIGN is a lectin receptor found on the surface of immune cells, mainly dendritic cells and macrophages. It recognizes pathogens through the interaction with mannose-rich carbohydrates present in their glycocalyx. This interaction triggers the immune response, but is sometimes taken advantage of by certain pathogens to facilitate their spread in the host organism. Blocking this interaction has a high potential in the prevention of a number of diseases, including HIV or hepatitis C.
The aim of this thesis is to synthetize carbohydrate-based ligands specific for ASGPR and DC-SIGN. The ASGPR ligands will be attached to lipid nanoparticles and used for the delivery of CRISPR/Cas9 system into hepatocytes. The DC-SIGN ligands will be used to study ligand-protein interactions in order to get better understanding of these complex processes.
Faculty of Environmental Technology

Carbon dioxide removal from flue gases produced by the combustion of fosil fuels and biomass in large energetic boilers

Ciahotný Karel, doc. Ing. CSc. ( cia...@vscht.cz)
The work is focused on the development of a suitable technological process for removing carbon dioxide from flue gases produced by the combustion of fossil fuels and biomass in large energy boilers. The technology should be used for flue gas cleaning at temperatures from 50 to 90 ° C. The development of suitable functionalized adsorbents with an liquid phase based on organic amines and imines is expected, which will ensure the chemical bonding of carbon dioxide on the surface of the adsorbent and thus its sufficient adsorption capacity for CO2. Regeneration of the saturated sorbent is assumed by heating it to temperatures of 120 - 180 ° C with steam. It is necessary to find suitable carrier (activated carbon, inorganic sorbents) and such a reagent, which will show good interconnection, so that there is no loss of organic reagent in the regeneration process. At the same time, the organic reagent must ensure a high affinity for CO2. Another goal of the work is to find a suitable way of anchoring the organic agent on the inner surface of the sorbent.
Faculty of Chemical Technology

Catalysts for alkaline energy conversion devices

Hnát Jaromír, Ing. Ph.D. ( h...@vscht.cz)
Alkaline energy conversion technologies represent one of the promising ways to increase the utilization of the installed renewable sources of energy. The advantage of the alkaline technologies lies in the possibility to avoid the necessity of the utilization of the Pt-group metals as catalysts for electrode reactions. On the other hand, the intensity of these technologies is generally lower when compare to alternatives. This work focuses on the synthesis and optimization of the new catalysts, their testing using standard procedures and under the real conditions of the energy conversion devices.
Faculty of Chemical Technology

Catalysts for alkaline energy conversion devices

Hnát Jaromír, Ing. Ph.D. ( h...@vscht.cz)
Alkaline energy conversion technologies represent one of the promising ways to increase the utilization of the installed renewable sources of energy. The advantage of the alkaline technologies lies in the possibility to avoid the necessity of the utilization of the Pt-group metals as catalysts for electrode reactions. On the other hand, the intensity of these technologies is generally lower when compare to alternatives. This work focuses on the synthesis and optimization of the new catalysts, their testing using standard procedures and under the real conditions of the energy conversion devices.
Faculty of Chemical Technology

Catalytic synthesis of biodegradable polymers based on carbon oxides

Merna Jan, doc. Ing. Ph.D. ( m...@vscht.cz)
The aim of the work is to synthesize catalytic systems for carbon monoxide conversion to biodegradable polymeric materials. In the first phase, the main attention will be focused on reaction of carbon oxides with epoxides leading to polyesters. Stereoregularity of the obtained polymers will be evaluated and their properties will be compared with highly stereoregular natural polymers. The work has interdisciplinary character with focus on organometallic and polymer synthesis followed by study of biological degradation of prepared materials.
Faculty of Chemical Technology

Catalytic transformation of methane to higher value products

Fíla Vlastimil, doc. Dr. Ing. ( f...@vscht.cz)
The high attention on the processes of transformation of methane (C2, C3 hydrocarbons eventually) from natural gas or biogas to higher value products is paid at present time. The processes such as non-oxidative catalytic methane aromatization, selective oxidation to methanol or dimethyl ether are used. The suitable catalyst for chosen process will be developed. The effect of the reaction conditions, catalyst carrier and formation of active phase on catalyst on the methane conversion, catalyst stability and yield of products will be studied.
Faculty of Chemical Technology

Catalytic transformation of methane to higher value products

Fíla Vlastimil, doc. Dr. Ing. ( f...@vscht.cz)
The high attention on the processes of transformation of methane (C2, C3 hydrocarbons eventually) from natural gas or biogas to higher value products is paid at present time. The processes such as non-oxidative catalytic methane aromatization, selective oxidation to methanol or dimethyl ether are used. The suitable catalyst for chosen process will be developed. The effect of the reaction conditions, catalyst carrier and formation of active phase on catalyst on the methane conversion, catalyst stability and yield of products will be studied.
Faculty of Chemical Technology

Cellulose acetate base motion picture films

Knotek Vítězslav, Ing. Ph.D. ( Vit...@vscht.cz)
Cinematographic films based on a cellulose triacetate base form a considerable part of collections in film archives. Films made in the period from the 1950s to the 1980s include a soundtrack in the form of a magnetic strip. The cellulose triacetate base is prone to degradation manifesting shrinkage, twist, and embrittlement. These dimensional changes can lead to errors in playing a magnetic soundtrack and difficult digitization. This work will focus on the study of cellulose triacetate film degradation processes and their influence on the magnetic soundtrack. One of the goals will be to develop methods for temporarily suppressing the symptoms of the degradation of the base and to determine the effect on the soundtrack. Furthermore, the possible catalytic effect of the magnetic soundtrack on the degradation of the base will be investigated.
Faculty of Chemical Technology

Ceramic composite filters for water treatment

Jankovský Ondřej, Doc. Ing. Ph.D. ( Ond...@vscht.cz)
The dissertation thesis will be focused on the development of advanced composite filters for the removal of pesticides, heavy metals and nanoplastics from contaminated groundwaters. The prepared composite filters will be coated using nanomaterials based on graphene oxide, cerium (IV) oxide, and titanium (IV) oxide.
Faculty of Chemical Technology

Ceramics with controlled properties in CaO-Al2O3-SiO2 system

Kloužková Alexandra, doc.Ing. CSc. ( ale...@vscht.cz)
Ceramic materials in the CaO-Al2O3-SiO2 system are used for many applications. Materials with controlled delay in the area of small length changes during firing are possible to prepare by suitable composition of raw materials and their subsequent heat treatment. The work will be focused on the prediction of mixtures behavior in the field of the area of small length changes and characterization of final products.
Faculty of Chemical Engineering

CFD modelling and experimental characterization of spray drying proces

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Low solubility of drugs represent significant drawback in development of new drug products. Possibility to improve this limitation is formulation of drug molecules in amorphous forms, e.g. using hot-melt extrusion, precipitation process or spray drying process. This project will focus on the preparation of amorphous solid forms of drugs using spray drying process. PhD student will be responsible for process modelling using Computational Fluid Dynamic (CFD) and experimental characterization of the process parameters. Developed model will be based on Euler-Lagrangian approach, where gas will be modeled as continuous phase while formed droplets will be tracked as individual entities. Atomization of liquid stream and formation of droplets will be described by combination of VOF-to-DPM approach allowing to model initial formation of droplets followed by their transformation into solid particles. Modelling effort will be combined with the experimental work, where we plan to characterize atomization conditions as well as properties of formed particles using on-line sersors for measurement of their size and shape. Impact of process parameters, such as gas and liquid flow rates, viscosity of liquid phase, and temperature and relative humidity during spray drying will be considered. In the last stage of the project, gained knowledge will be used to scale up of the process from laboratory scale to pilot scale size.
Faculty of Chemical Engineering

CFD simulation of fire suppression In enclosed spaces

Jahoda Milan, doc. Dr. Ing. ( jah...@vscht.cz)
Stable fire extinguishers are standard fire protection. In the regular arrangement of the fire section, the location of the nozzles is given normatively. In the case of a nonstandard geometry arrangement or when protecting equipment with highly flammable substances, it is necessary to solve the design of the nozzles' position and function using advanced fire engineering analysis methods. These methods include computational fluid dynamics, CFD. The dissertation is focused on CFD modelling the effect of stable mist equipment on fire suppression in closed objects. The work aims to find the model's critical parameters and their values for calculating the nozzles' location for optimal fire protection.
Faculty of Chemical Technology

Clinkerless hydraulic ternary binder

Šídlová Martina, Ing. Ph.D. ( mar...@vscht.cz)
Škvára František, doc. RNDr. DrSc. ( skv...@vscht.cz)
The aim of the dissertation thesis is the preparation of a clinkerless hydraulic ternary binder with lower energy requirements and lower CO2 emissions in comparison to Portland cement, and which contains amorphous C-A-S-H as the binder phase. The development of the binder would be aimed at the lime activation of aluminosilicates, especially calcined clays. The work would also include a study of the reactivity of calcined clays from low quality and waste kaolinitic rocks. Another raw material of the binder would be waste gypsums. Hydration products would be study by a number of methods: XRD, SEM + ED, IR, or NMR Solid State, TGA and porosimetry. The work would include the determination of mechanical properties of the prepared ternary binder after the hydration period in a time horizon longer than 1 year. The work is part of an effort to increase the durability of concrete, because modern concrete has the lower durability in comparison to Roman concrete, which has resisted to atmospheric and sea water condition for more than 2,000 years. It turns out that in Roman concrete the main binder phase is C-A-S-H, which is attributed to the high durability of Roman concrete.
Faculty of Chemical Technology

Coating for induction heating of glass

Míka Martin, doc. Dr. Ing. ( m...@vscht.cz)
Faculty of Chemical Engineering

Computational electrochemistry: Developement of new methods and applications

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The Thesis focuses on developement of new apprroaches for charge transfer modelling. The work includes both the charge transfer between molecules as well as the charge transfer between a molecule and electrode. Modern approaches based on ab initio molecular dynamics will be used. For more information, see http://photox.vscht.cz/
Faculty of Chemical Engineering

Computer modelling of non-thermal plasma and electrical discharges

Scholtz Vladimír, doc. Ing. Ph.D. ( sch...@vscht.cz)
Klenivskyi Myron, Ing. Ph.D. ( kle...@vscht.cz)
Scope of this work is the computer modelling of non-thermal plasma in electrical discharges. It may help to clarify the plasma-chemical reactions in discharges and the spatial distribution of generated particles. Work deals with the issue of plasma physics, computer modelling, possible method for the modelling of selected problem and comparison with the experiment. It is also possible to combine this work with the investigation of bactericidal effects of plasma or the interaction with organic structures.
Faculty of Environmental Technology

Continuous ion chromatography for the separation of alkali metal ions

Jelínek Luděk, doc. Ing. Ph.D. ( jel...@vscht.cz)
Faculty of Chemical Engineering

Continuous preparation of multicomponent drug solid forms

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Skořepová Eliška, Ing. Ph.D. ( sko...@seznam.cz)
Screening of new solid forms is typically done in small scale systems including shaken flasks, evaporating systems, ball mills etc., which by design operate in a batch model. Once new solid form is discovered scaling its production is often very complex task. In this project we plan to test capability to utilize the rotary extruder to prepare multicomponent solid forms of drug substances such as salts, co-crystals or co-amorphs. Initially we will use ball mill to prepare new solid forms of selected drug substance. Upon characterization we will upscale of the production process to the application of extrusion, where same form of the drug substance will be prepared in a continuous mode. Detailed investigation of the process parameters will be done to optimize the production process. Both products will be thoroughly characterized including XRD, NMR, Raman spectroscopy, DSC, SEM, particle characterization, measurement of dissolution and stability testing.
Faculty of Chemical Engineering

Continuous preparation of multicomponent drug solid forms

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Skořepová Eliška, Ing. Ph.D. ( sko...@seznam.cz)
Screening of new solid forms is typically done in small scale systems including shaken flasks, evaporating systems, ball mills etc., which by design operate in a batch model. Once new solid form is discovered scaling its production is often very complex task. In this project we plan to test capability to utilize the rotary extruder to prepare multicomponent solid forms of drug substances such as salts, co-crystals or co-amorphs. Initially we will use ball mill to prepare new solid forms of selected drug substance. Upon characterization we will upscale of the production process to the application of extrusion, where same form of the drug substance will be prepared in a continuous mode. Detailed investigation of the process parameters will be done to optimize the production process. Both products will be thoroughly characterized including XRD, NMR, Raman spectroscopy, DSC, SEM, particle characterization, measurement of dissolution and stability testing.
Faculty of Chemical Engineering

Controlling drug crystals properties during crystallization and their impact on consequent unit operations

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Skořepová Eliška, Ing. Ph.D. ( sko...@seznam.cz)
Active Pharmaceutical Ingredients (APIs) are commonly small molecules, which are prepared by crystallization process. Properties of prepared crystals (i.e. physico-chemical but also formulation properties) are strongly dependent on the used drug solid form, their size and crystal morphology. Therefore, the focus of this project is to study impact of crystallization process parameters and post-processing step on the prepared drug crystals with respect to size, morphology and polymorphism. Temperature modulated batch crystallization will be combined with wet-milling process to control the shape as well as flow properties of prepared drug crystals. Crystallization step will be combined with following steps, i.e. filtration and drying, to evaluate the impact of the crystal size and shape on the efficiency of these unit operations. In parallel, we will also study impact of washing step on the amount of remaining solvent and the polymorphic stability of the final product. While pharmaceutical industry is typically using batch operation, as a part of this project we will investigate the possibility to prepare same drug crystals as studied in batch mode in a continuous process. Process analytical technology capable to measure crystal size, shape and morphology com will analysis of composition via Raman spectroscopy will be used to ensure constant product quality. On-line measurement will be supported by off-line measurement via SEM, IR spectroscopy, XRD and NMR. Student will be also involved in the scale up of developed process.
Faculty of Chemical Engineering

Controlling drug crystals properties during crystallization and their impact on consequent unit operations

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Ridvan Luděk, Ing. Ph.D. ( lud...@zentiva.cz)
Active Pharmaceutical Ingredients (APIs) are commonly small molecules, which are prepared by chemical synthesis followed by crystallization process. Properties of prepared crystals (i.e. physico-chemical but also formulation properties) are strongly dependent on the used drug solid form, their size and crystal morphology. Therefore, the focus of this project is to study impact of crystallization process parameters and post-processing step on the prepared drug crystals with respect to size, morphology and polymorphism. Temperature modulated batch crystallization will be combined with wet-milling process to control the shape as well as flow properties of prepared drug crystals. Crystallization step will be combined with filtration and drying, to evaluate the impact of the crystal size and shape on the efficiency of these unit operations. In parallel, we will also study impact of washing step on the amount of remaining solvent and the polymorphic stability of the final product. While pharmaceutical industry is typically using batch operation, as a part of this project we will investigate the possibility to prepare same drug crystals as studied in batch mode in a continuous process. Process analytical technology capable to measure crystal size, shape and morphology combined will analysis of composition via Raman spectroscopy will be used to ensure constant product quality. On-line measurement will be supported by off-line measurement via SEM, IR spectroscopy, XRD and NMR. Student will be also involved in the scale up of developed process.
Faculty of Food and Biochemical Technology

Control of membrane filtration process with backwash

Bubník Zdeněk, prof. Ing. CSc. ( bub...@vscht.cz)
Henke Svatopluk, Ing. Ph.D. ( sva...@vscht.cz)
Tangential flow membrane filtration is used as a separation method in all kind of industries. This is a process in which the membrane forms a selective barrier and the inlet is continuously fed along the membrane. Unlike conventional filtration, there is no formation of filtration cake and filtration can take place for a long time; pressure is most often the driving force. The whole system is then composed of membrane modules, pressure gradient pumps and control valves to ensure the desired direction of the filtered medium. The work is focused on the filtration of food products with the aim to isolate, separate or thicken the selected component from the feed mixture, using the measured data to build a filtration model and use it in the design and implementation of a higher management system. The measurement will be carried out on the existing double-pump filtration unit TIA with ceramic membrane modules and backwash unit. The station is also equipped with pressure, temperature, flow and primary pressure control via flap valves via the Siemens S1200 programmable logic controller.
Faculty of Chemical Technology

Covalent catalysis with flavins

Cibulka Radek, prof. Ing. Ph.D. ( cib...@vscht.cz)
Flavins are natural compounds acting as cofactors in redox enzymes. The mechanism of transformations provided by flavoenzymes are known for several decades. Nevertheless, very recently, new principles of a substrate activation have been described. They are mainly based on covalent bonding of the substrate to the flavin moiety. Being inspired by these newly discovered enzymatic processes, new flavin artificial catalytic systems for application in organic synthesis will be designed. Main application will be in-situ umpolung of enolates.
Faculty of Chemical Technology

Covalent catalysis with flavins

Cibulka Radek, prof. Ing. Ph.D. ( cib...@vscht.cz)
Flavins are natural compounds acting as cofactors in redox enzymes. The mechanism of transformations provided by flavoenzymes are known for several decades. Nevertheless, very recently, new principles of a substrate activation have been described. They are mainly based on covalent bonding of the substrate to the flavin moiety. Being inspired by these newly discovered enzymatic processes, new flavin artificial catalytic systems for application in organic synthesis will be designed. Main application will be in-situ umpolung of enolates.
Faculty of Chemical Engineering

CO2 capture. Industrial process optimization.

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
CO2 capture belongs to frequent industrial needs, both in the cases of low concentration CO2 removal from waste gases and in the cases of main process streams, e.g., in hydrogen production, when high amount/concentration is to be removed. Just the last example represents the process, which the PhD thesis will be focused to. In the premises of Unipetrol company, the CO2 capture unit is presumed to be permanently optimized. In accordance with the needs of the industrial partner, the experimental research goals will involve i) durability / degradability of the solution currently used in the process, ii)absorption efficiencies and selectivities (H2S/CO2) of new absorbents and iii)the influence of low concentration admixtures, e.g., Fe, Ni and V metals, on the CO2 capture efficiency. The PhD student will acquire valuable experience of industrial area life because he/she will be able independently act in the Unipetrol premises, will cooperate with industrial research department UniCRE and will find here both well-equipped laboratories and experienced consultants.
Development principles: 1. Get familiar with the principles of the processes of absorption accompanied by chemical reaction and with their mathematical descriptions.
2. Perform the literary research aimed to modern absorption liquids used in CO2 capture and their properties.
3. Get familiar with the technology used in Unipetrol Litvínov and study an available firm literature describing it.
4. According to the specific requirements of the industrial partner and the experimental possibilities of all registered workplaces, perform experimental work leading to the set goals (see annotations).
5. Based on the literature findings and on the results of your own experimental results, propose modifications to the operation of CO2 pressure washers.
Faculty of Chemical Engineering

CO2 capture. Industrial process optimization.

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
CO2 capture belongs to frequent industrial needs, both in the cases of low concentration CO2 removal from waste gases and in the cases of main process streams, e.g., in hydrogen production, when high amount/concentration is to be removed. Just the last example represents the process, which the PhD thesis will be focused to. In the premises of Unipetrol company, the CO2 capture unit is presumed to be permanently optimized. In accordance with the needs of the industrial partner, the experimental research goals will involve i) durability / degradability of the solution currently used in the process, ii)absorption efficiencies and selectivities (H2S/CO2) of new absorbents and iii)the influence of low concentration admixtures, e.g., Fe, Ni and V metals, on the CO2 capture efficiency. The PhD student will acquire valuable experience of industrial area life because he/she will be able independently act in the Unipetrol premises, will cooperate with industrial research department UniCRE and will find here both well-equipped laboratories and experienced consultants.
Development principles: 1. Seznamte se s procesy absorpce doprovázené chemickou reakcí a se způsoby jejich matematického popisu.
2. Proveďte literární rešerši zaměřenou na moderní absorpční roztoky pro vypírky CO2 a jejich vlastnosti.
3. Seznamte se technologií provozovanou v podniku Unipetrol Litvínov a prostudujte dostupnou firemní literaturu tuto technologii popisující
4. Podle konkrétních požadavků průmyslového partnera a experimentálních možností všech zůčatněných pracovišť proveďte experimentální práce vedoucí k vytčeným cílům (viz anotace)
5. Na základě literárních zjištění a výsledků vlastní experimentální práce navrhněte úpravy provozu tlakových vypírek CO2
Faculty of Food and Biochemical Technology

Critical assessment of potential of various gas chromatography - mass spectrometry platforms in food analysis

Hajšlová Jana, prof. Ing. CSc. ( haj...@vscht.cz)
Stupák Michal, Ing. Ph.D. ( mic...@vscht.cz)
The doctoral thesis will focus on a critical assessment of performance characteristics of analytical methods employing various set-ups of gas chromatographic (GC) separation systems and various types of mass spectrometric analyzers. For separation of complex mixtures, the use of two-dimensional gas chromatography (GCxGC) will be tested, for detection, tandem time-of-flight (Q-TOF) high resolution and/or triple quadrupole (QqQ) mass analysers will be employed. The applications will be concerned with food quality, safety and authenticity evaluation. Special attention will be paid to approaches based on non-target screening (fingerprinting / profiling).
Faculty of Food and Biochemical Technology

Critical assessment of potential of various gas chromatography - mass spectrometry platforms in food analysis

Hajšlová Jana, prof. Ing. CSc. ( haj...@vscht.cz)
Stupák Michal, Ing. Ph.D. ( mic...@vscht.cz)
The doctoral thesis will focus on a critical assessment of performance characteristics of analytical methods employing various set-ups of gas chromatographic (GC) separation systems and various types of mass spectrometric analyzers. For separation of complex mixtures, the use of two-dimensional gas chromatography (GCxGC) will be tested, for detection, tandem time-of-flight (Q-TOF) high resolution and/or triple quadrupole (QqQ) mass analysers will be employed. The applications will be concerned with food quality, safety and authenticity evaluation. Special attention will be paid to approaches based on non-target screening (fingerprinting / profiling).
Faculty of Environmental Technology

Damage to high-alloyed materials in cooling water circuit and suggestion of an effective life management procedure

Macák Jan, doc. Ing. CSc. ( mac...@vscht.cz)
Stainless steels are widely used material in a nuclear power plant. Stainless steels are used also in the cooling water circuit. However, under the conditions of a cooling water circuit, a possible microbial activity can aggravate risks for the use of stainless steels. The aim of this work is to increase a reliability of stainless steels performance in a cooling water circuit and to propose procedures for effective management of their service life.
Faculty of Chemical Engineering

Design and application of supra-lipidic structures

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Lizoňová Denisa, Ing. ( den...@gmail.com)
The gastro-intestinal transit, emulsification, digestion and absorption of lipidic components from food is crucial not only from the nutritional point of view but also for the dissolution and absorption of many drugs, and therefore their bioavailability. An increasing number of active pharmaceutical ingredients (APIs) that enter the drug development process are highly lipophilic, which makes their bioavailability susceptible to patient-specific dietary habits and often leads to undesired phenomena such as positive food effect. For some APIs, the bioavailability can be up to five times higher when taken on a full stomach compared to bioavailability in the fasted state. The aim of this project is to develop a formulation platform that would make the dissolution, absorption and pharmacokinetics of lipophilic APIs independent of food intake, while not containing a large amount of lipids in the formulation itself. The idea is to create particles that “look like lipids” on the outside but their volume contains predominantly the API or other excipients. Such structures can include e.g. drug suspensions encapsulated in giant liposomes or their aggregates, drug nanocrystals coated by a phospholipid monolayer, or drug-loaded mesoporous silica particles encapsulated within a lipid bi-layer. These elementary structures can also be combined, carrying e.g. several different APIs, functional excipients for absorption enhancement, or pH modifiers that can further reduce patient-to-patient variability.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

Design and application of supra-lipidic structures

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Lizoňová Denisa, Ing. ( den...@gmail.com)
The gastro-intestinal transit, emulsification, digestion and absorption of lipidic components from food is crucial not only from the nutritional point of view but also for the dissolution and absorption of many drugs, and therefore their bioavailability. An increasing number of active pharmaceutical ingredients (APIs) that enter the drug development process are highly lipophilic, which makes their bioavailability susceptible to patient-specific dietary habits and often leads to undesired phenomena such as positive food effect. For some APIs, the bioavailability can be up to five times higher when taken on a full stomach compared to bioavailability in the fasted state. The aim of this project is to develop a formulation platform that would make the dissolution, absorption and pharmacokinetics of lipophilic APIs independent of food intake, while not containing a large amount of lipids in the formulation itself. The idea is to create particles that “look like lipids” on the outside but their volume contains predominantly the API or other excipients. Such structures can include e.g. drug suspensions encapsulated in giant liposomes or their aggregates, drug nanocrystals coated by a phospholipid monolayer, or drug-loaded mesoporous silica particles encapsulated within a lipid bi-layer. These elementary structures can also be combined, carrying e.g. several different APIs, functional excipients for absorption enhancement, or pH modifiers that can further reduce patient-to-patient variability.

Study Programme:

Faculty of Chemical Engineering

Design of high performance flexible supercapacitors based on cellulose nanofibrils and conductive polymers

Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
The present project aims at designing of novel, flexible and lightweight electrodes based on sustainable materials. Electrodes will be then used for development of high performance supercapacitors with tailored structure and high capacitance. Herein, the emerging bio-sourced cellulose nanofibrils (CNF) will be employed as a matrix to prepare supercapacitor electrodes with electrically conducting polymers (ECP) and nanofillers (e.g. carbon nanomaterials). CNF will act as a mechanical skeleton capable of high deformation and as a useful template for tailoring functionalities and preparing porous networks in form of films. New approaches of polymer/nanofiller compatibilization will be investigated to combine together different materials and different properties into free-standing CNF-ECP based electrode films with optimal morphology and properties. The electrodes exhibiting the best capacitances, flexibility and thermal stability will be used in fabrication and testing of supercapacitor devices.
Faculty of Chemical Engineering

Design of high performance flexible supercapacitors based on cellulose nanofibrils and conductive polymers

Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
Mazúr Petr, Ing. Ph.D.
The present project aims at designing of novel, flexible and lightweight electrodes based on sustainable materials. Electrodes will be then used for development of high performance supercapacitors with tailored structure and high capacitance. Herein, the emerging bio-sourced cellulose nanofibrils (CNF) will be employed as a matrix to prepare supercapacitor electrodes with electrically conducting polymers (ECP) and nanofillers (e.g. carbon nanomaterials). CNF will act as a mechanical skeleton capable of high deformation and as a useful template for tailoring functionalities and preparing porous networks in form of films. New approaches of polymer/nanofiller compatibilization will be investigated to combine together different materials and different properties into free-standing CNF-ECP based electrode films with optimal morphology and properties. The electrodes exhibiting the best capacitances, flexibility and thermal stability will be used in fabrication and testing of supercapacitor devices.
Faculty of Environmental Technology

Determination of the composition of natural gas using Raman spectroscopy

Hlinčík Tomáš, doc. Ing. Ph.D. ( Tom...@vscht.cz)
Natural gas contains hydrocarbon and inert components which can be commonly determined using gas chromatography. Utilization Ramana spectroscopy for analysis of substances contained in the natural gas has not been more widely studied and the use of spectral methods has great potential in the future compared with chromatographic methods. The aim of this work is the study of qualitative and quantitative analysis of the components of natural gas using Raman spectroscopy.
Faculty of Chemical Engineering

Development and application of a digital twin bioreactor model for modelling of production of biopharmaceuticals

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Production of biopharmaceuticals is typically done in a stirred and sparged bioreactors, which combine a fluid flow and microorganism metabolism to produce final product with desired amount and quality. However, often interplay between poor mixing, low dissolved oxygen concentrations, high amount of CO2 and hydrodynamic stress negatively affect the cell behavior resulting in a lower product amount and decreased product quality. In this project we will use recently development CFD model of stirred and sparged bioreactor capable to predict hydrodynamic stress and mixing time and extend it to descritpion of dissolved O2 and CO2 concentrations, uptake of nutrients and release of metabolic products. Information about the fluid flow will be combined with a hybrid model describing detailed microbial metabolism. Tuning of model parameters and its testing will be done against experimental data measured in fermenters of various sizes. Once validated, developed model will be used to test and propose modifications of existing fermenters to optimize the fermentation process.
Faculty of Chemical Engineering

Development and application of a digital twin bioreactor model for modelling of production of biopharmaceuticals

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Production of biopharmaceuticals is typically done in a stirred and sparged bioreactors, which combine a fluid flow and microorganism metabolism to produce final product with desired amount and quality. However, often interplay between poor mixing, low dissolved oxygen concentrations, high amount of CO2 and hydrodynamic stress negatively affect the cell behavior resulting in a lower product amount and decreased product quality. In this project we will use recently development CFD model of stirred and sparged bioreactor capable to predict hydrodynamic stress and mixing time and extend it to descritpion of dissolved O2 and CO2 concentrations, uptake of nutrients and release of metabolic products. Information about the fluid flow will be combined with a hybrid model describing detailed microbial metabolism. Tuning of model parameters and its testing will be done against experimental data measured in fermenters of various sizes. Once validated, developed model will be used to test and propose modifications of existing fermenters to optimize the fermentation process.
Faculty of Chemical Technology

Development and verification of hydrometallurgical routes for recovering critical metals from mineralized waters

Vu Nguyen Hong, Ing. Ph.D. ( ...@vscht.cz)
The thesis deals with development and verification of hydrometallurgical routes for recovering critical metals from mineralized waters (brines) on the territory of the Czech republic. The metals of interest are mainly lithium, rubidium, boron and others, which are present in koncentration up to few hundreds ppm in the chloride and sulfate solutions. The methods such as membrane separation, ion-exchange and solvent extraction will be studied for separation and concentration of the metals of interest. From the concentrated solutions the metals will be obtained in their compounds form by suitable combination of traditional hydrometallurgical methods.
Faculty of Food and Biochemical Technology

Development of analytical procedures for the determination of new per- and polyfluoroalkylated substances in foods and biological samples

Pulkrabová Jana, prof. Ing. Ph.D. ( jan...@vscht.cz)
Dvořáková Darina, Ing. Ph.D. ( lan...@vscht.cz)
This dissertation will be focused on the development of ultra-sensitive analytical methods for the determination of a wide range of per- and polyfluoroalkylated substances (PFASs) in foods, especially of animal origin, and in drinking water, which are the main dietary source of human exposure. The work will be firstly aimed on the extension of existing methods by new substances, e.g. short-chain carboxylic acids (C2-C3), telomeric compounds including their precursors. Liquid chromatography coupled with tandem mass spectrometry will be used for the analysis of targeted chemicals, based on their polarity and volatility, for some substances gas chromatography with mass spectrometry will also be applied, to achieve required performance characteristics. Subsequently, the new analytical procedures will be applied to assess the exposure of the population of the Czech Republic to these substances on the basis of their analysis in selected food commodities and drinking water. The dissertation will also include a study in the field of human biological monitoring, where the targeted PFASs will also be determined in human biological samples such as breast milk, blood serum and urine. Distribution of these substances in individual types of samples will be evaluated. This work will provide new data necessary for the complex risk assessment associated with the exposure of different population groups to these substances
Faculty of Food and Biochemical Technology

Development of analytical procedures for the determination of new perfluoroalkylated substances in food and biological samples

Pulkrabová Jana, prof. Ing. Ph.D. ( jan...@vscht.cz)
Dvořáková Darina, Ing. Ph.D. ( lan...@vscht.cz)
This dissertation will be focused on the development of ultra-sensitive analytical methods for the determination of a wide range of perfluoroalkylated compounds (PFAS) in foods, especially of animal origin, and in drinking water, which are the main dietary source of human exposure. The work will be firstly aimed on the extension of existing methods by new substances, e.g. short-chain carboxylic acids (C2-C3), telomeric compounds including their precursors. Liquid chromatography coupled with tandem mass spectrometry will be used for the analysis of targeted chemicals, based on their polarity and volatility, for some substances gas chromatography with mass spectrometry will also be applied, to achieve required performance characteristics. The new analytical procedures will subsequently be applied to assess the exposure of the population of the Czech Republic to these substances on the basis of their analysis in selected food commodities and drinking water. The dissertation will also include a study in the field of human biological monitoring, where the targeted PFAS will also be determined in human biological samples such as breast milk, blood serum and urine. It will be evaluated for the distribution of these substances in individual types of samples. This work will provide new data necessary for the complex risk assessment associated with the exposure of different population groups to these substances.
Faculty of Chemical Technology

Development of atmospheric corrosion monitoring techniques

Kouřil Milan, doc. Ing. Ph.D. ( kou...@vscht.cz)
Majority of metallic objects, like metallic structures, vehicles, construction elements, cultural heritage, etc., is exposed in atmosphere. It deals with extreme costs and safety risks originated in corrosion. Corrosion protection is applied to avoid or minimize the impacts. There are many corrosion monitoring techniques available which might be applied for verification of corrosion countermeasures efficiency. However, the techniques must be accommodated to specific conditions of the particular fields. The project is focused on development of new device for atmospheric corrosion monitoring. The principle of the technique based on the electrical resistance method will be inovated. New corrosion sensors, electronics, software and data transfer and treatment will developed as well.
Faculty of Chemical Technology

Development of atmospheric corrosion monitoring techniques

Kouřil Milan, doc. Ing. Ph.D. ( kou...@vscht.cz)
Majority of metallic objects, like metallic structures, vehicles, construction elements, cultural heritage, etc., is exposed in atmosphere. It deals with extreme costs and safety risks originated in corrosion. Corrosion protection is applied to avoid or minimize the impacts. There are many corrosion monitoring techniques available which might be applied for verification of corrosion countermeasures efficiency. However, the techniques must be accommodated to specific conditions of the particular fields. The project is focused on development of new device for atmospheric corrosion monitoring. The principle of the technique based on the electrical resistance method will be inovated. New corrosion sensors, electronics, software and data transfer and treatment will developed as well.
Faculty of Food and Biochemical Technology

Development of gluten-free sourdoughs and optimization of their physicochemical and nutritional parameters

Sluková Marcela, doc. Ing. Ph.D. ( Mar...@vscht.cz)
Skřivan Pavel, Ing. CSc. ( Pav...@vscht.cz)
Recently, there has been an increase in the population's interest in gluten-free products of all kinds, especially bread and other bakery products. Gluten-free products are required not only by groups of people suffering from celiac disease or other forms of gluten intolerance, but also by many other takers who are not diagnosed with intolerance. At the same time, there is a growing interest in bakery products containing various types of vital sourdoughs. The aim of this work will be testing and optimization of technological procedures used in the preparation of sourdoughs from gluten-free cereals and pseudocereals (sorghum, rice and buckwheat). In particular, procedures for activation of fermentation processes from available commercial starter cultures and also spontaneously started based on natural flour microflora will be examined. Furthermore intrinsic fermentation conditions (temperature, time, consistence). The procedures will be optimized on the basis of selected physicochemical characteristics of the resulting sourdoughs (especially pH and titratable acidity, content and mutual ratios of organic acids, profiles of volatile compounds), selected nutritional characteristics and further on the sensory properties of the sourdoughs and experimental bakery products prepared using them.
Faculty of Chemical Engineering

Development of methods for studying extremely low vapor pressures

Štejfa Vojtěch, Ing. Ph.D. ( STE...@vscht.cz)
Fulem Michal, prof. Ing. Ph.D. ( ful...@vscht.cz)
Faculty of Chemical Engineering

Development of modern electromagnetic radiation shields as passive protection of information against eavesdropping

Kopecký Dušan, doc. Ing. Ph.D. ( kop...@vscht.cz)
Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
The proliferation of modern electronics, integrated circuits, microprocessors and communication and computer technology in general brings with it a high risk of disclosing critical information about the infrastructure in which these elements are used. In the extreme case, there may be a leak or takeover of administrative privileges, which can be misused for digital vandalism, disclosure of important information or attacks on the infrastructure itself. One of the very effective and difficult to detect methods of these attacks is the remote eavesdropping on information that is emanated from electronic devices in the form of electric or magnetic fields. With the development of inexpensive radio technology and as a result of readily available libraries and signal processing algorithms, such an attack may no longer be the sole domain of rich, state-sponsored organizations, but may gradually be adopted by the mainstream hacking community and misused for criminal purposes.
The aim of this work is to explore the possibilities and develop and test light and flexible protective shields based on modern nanomaterials, which will serve as an effective passive protection of electronic devices against remote eavesdropping. For this purpose, new composite materials based on electrically conductive nanoparticles with magnetic properties will be prepared. The possibilities of their compatibility with the carrier, chemical structure and morphology, mechanical, electrical and magnetic properties and methods and the possibilities of their processing into the required shape and form suitable for use in miniature electronics will be studied. The experiments will also include testing passive shields in simulated and real conditions and evaluating their ability to dampen electromagnetic waves emitted by electronic devices.
Faculty of Chemical Engineering

Development of modern electromagnetic radiation shields as passive protection of information against eavesdropping

Kopecký Dušan, doc. Ing. Ph.D. ( kop...@vscht.cz)
Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
The proliferation of modern electronics, integrated circuits, microprocessors and communication and computer technology in general brings with it a high risk of disclosing critical information about the infrastructure in which these elements are used. In the extreme case, there may be a leak or takeover of administrative privileges, which can be misused for digital vandalism, disclosure of important information or attacks on the infrastructure itself. One of the very effective and difficult to detect methods of these attacks is the remote eavesdropping on information that is emanated from electronic devices in the form of electric or magnetic fields. With the development of inexpensive radio technology and as a result of readily available libraries and signal processing algorithms, such an attack may no longer be the sole domain of rich, state-sponsored organizations, but may gradually be adopted by the mainstream hacking community and misused for criminal purposes.
The aim of this work is to explore the possibilities and develop and test light and flexible protective shields based on modern nanomaterials, which will serve as an effective passive protection of electronic devices against remote eavesdropping. For this purpose, new composite materials based on electrically conductive nanoparticles with magnetic properties will be prepared. The possibilities of their compatibility with the carrier, chemical structure and morphology, mechanical, electrical and magnetic properties and methods and the possibilities of their processing into the required shape and form suitable for use in miniature electronics will be studied. The experiments will also include testing passive shields in simulated and real conditions and evaluating their ability to dampen electromagnetic waves emitted by electronic devices.
Faculty of Chemical Engineering

Development of nanoparticles for drug delivery in wound healing

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Main focus of this project is to synthesize multifunctional vesicles loaded with hydrophilic and hydrophobic drugs to be used in wound healing. Since these particles can be used directly or as an intermediate during skin dressing their detailed characterization and colloidal stability will be essential. Student will study the impact of vesicle composition (primary system will be surfactant and cholesterol forming niosomes) and method of preparation on the size and properties of the formed nano carriers as well as drug encapsulation efficiency. Once drug will be loaded into vesicles the release kinetics will be measured as a function of molecular weight of used surfactants and ionic strength. Quality of the prepared samples will be characterized by combination of analytical techniques including 3D modulated DLS, Depolarized DLS, static light scattering, optical video microscopy combined with image analysis and cryo-TEM. While batch production mode is simple to realize, part of the project will be also preparation of multifunctional vesicles in microfluidic systems and compare their properties with batch production method.
Faculty of Chemical Engineering

Development of nanoparticles for drug delivery in wound healing

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Main focus of this project is to synthesize multifunctional vesicles loaded with hydrophilic and hydrophobic drugs to be used in wound healing. Since these particles can be used directly or as an intermediate during skin dressing their detailed characterization and colloidal stability will be essential. Student will study the impact of vesicle composition (primary system will be surfactant and cholesterol forming niosomes) and method of preparation on the size and properties of the formed nano carriers as well as drug encapsulation efficiency. Once drug will be loaded into vesicles the release kinetics will be measured as a function of molecular weight of used surfactants and ionic strength. Quality of the prepared samples will be characterized by combination of analytical techniques including 3D modulated DLS, Depolarized DLS, static light scattering, optical video microscopy combined with image analysis and cryo-TEM. While batch production mode is simple to realize, part of the project will be also preparation of multifunctional vesicles in microfluidic systems and compare their properties with batch production method.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

Development of nanoparticles for drug delivery in wound healing

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
Main focus of this project is to synthesize multifunctional vesicles loaded with hydrophilic and hydrophobic drugs to be used in wound healing. Since these particles can be used directly or as an intermediate during skin dressing their detailed characterization and colloidal stability will be essential. Student will study the impact of vesicle composition (primary system will be surfactant and cholesterol forming niosomes) and method of preparation on the size and properties of the formed nano carriers as well as drug encapsulation efficiency. Once drug will be loaded into vesicles the release kinetics will be measured as a function of molecular weight of used surfactants and ionic strength. Quality of the prepared samples will be characterized by combination of analytical techniques including 3D modulated DLS, Depolarized DLS, static light scattering, optical video microscopy combined with image analysis and cryo-TEM. While batch production mode is simple to realize, part of the project will be also preparation of multifunctional vesicles in microfluidic systems and compare their properties with batch production method.

Study Programme:

Faculty of Chemical Technology

Development of new ultralight-weight magnesium-based alloys for aviation

Kubásek Jiří, Ing. Ph.D. ( KUB...@vscht.cz)
Magnesium alloys are characterized by low density and a relatively high strength-to-weight ratio. From this point of view, they are interesting materials for applications in the automotive and aerospace industries. To improve the mechanical and corrosion properties, other metals like Al, Zn, Mn, Y, Nd, Gd, etc are very added. An interesting alloying element is Li, which as the lightest metal further reduces the density of the resulting alloy. Such behaviour is desirable for the potential reduction of CO2 emissions. Depending on the Li concentration, it is also possible to achieve a bcc structure and thus significantly improve the plasticity of the material. However, the strength and corrosion resistance of Mg-Li alloys are relatively poor, which prevents their wider use.
This work aims to design and prepare by various processes including conventional casting and extrusion, as well as unconventional methods of powder metallurgy (mechanical alloying, spark plasma sintering - SPS, selective laser melting - SLM) magnesium alloys with Li and other alloying elements. The work will characterize in detail the influence of the microstructure on the mechanical and corrosion properties of the prepared materials. Besides, the optimization of selected preparation procedures leading to the required improvements of properties will be performed. Close cooperation with the organizations like Institute of Metals and Technology, Ljubljana and the Institute of Materials and Machine Mechanics, SAS, Bratislava is expected.
Faculty of Chemical Engineering

Development of scaling-up methods of industrial mechanically agitated reactors

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
Fermenters or, in general, mechanically agitated aerated vessels are frequently used in industry for the intensification of gas-liquid mass transfer, especially in the case of a low gas to liquid volume ratio. Industrial processes as aerobic fermentations, hydrogenations and chlorinations can serve as examples of their application. In many processes the gas-liquid interfacial mass transfer becomes the rate determining step, so the volumetric mass transfer coefficient becomes the key parameter in the design. Mass transfer laboratory pays many year effort to gas-liquid mass transfer measurement in mechanically agitated gas-liquid dispersions with the aim to formulate the scaling-up rules for industrial vessels design. In the frame of this research an extensive experimental work has been done using various batch types (coalescent, non-coalescent, viscous) and for various impeller types (from purely axially pumping to purely radially pumping ones) and their combinations. After collecting large data series in laboratory scale vessels, experimental work continues using pilot-plant vessel equipped with a modern computer controlled regulation and data acquisition system in the form used also in industry. The aim of the PhD work is to collect the transport characteristics (impeller power, gas hold-up and volumetric mass transfer coefficient, kLa) measured in the pilot-plant vessel using various types of impellers (e.g., Rushton Turbine, Lightnin, Techmix, Pitched Blade impellers). The experimental research will be now focused to the transport characteristics in viscous batch and in the presence of solid particles. Both high viscosity and solid particles presence are typical features of industrial fermentation broths. Based both on the laboratory data and on the pilot-plant data the scaling-up rules will be formulated, which will be employable for industrial gas-liquid contactors design. A PhD student will get acquainted with the design methods of other gas-liquid and vapour-liquid processes as well, because he/she will work in the team dealing also with the absorption columns, distillation columns and ejector bubble columns design. More info: Tomáš Moucha, UCT building B, ground floor, room No. T02a, phone: 220 443 299, e-mail: mouchat@vscht.cz
Development principles: 1. Get familiar with the methodology of industrial gas-liquid contactors (GLC) design and with the basics of an interfacial mass transfer.
2. Get familiar with the transport characteristics used in industrial GLC design and study the interfacial mass transfer theories
3. Learn the experimental techniques to determine the transport characteristics needed in industrial GLC design and get familiar with the evaluation models
4. Build a plan of experiments and evaluation procedures to obtain original results complementary with those measured on the workplace earlier
5. With the use of the database already developed on the workplace, expand the design methodology of GLC, for example, by liquid viscosity effect
Faculty of Chemical Technology

Development of the bipolar plates for the PEM type fuel cells

Bouzek Karel, prof. Dr. Ing. ( bou...@vscht.cz)
Bipolar plates represent an important part of the fuel cell construction set-up. They contribute significantly also to the fuel cells stack production costs. This is because of corossion aggressiveness of their working environment and related material demands. Target of this project is to develop alternative approach based on utilisation of steel based plates surface modified by suitable composite. Inseparable part of the project is CFD modelling of the reactants and products flow in the flow field geometry targeted to optimise their structure.
Faculty of Chemical Technology

Development of the bipolar plates for the PEM type fuel cells

Bouzek Karel, prof. Dr. Ing. ( bou...@vscht.cz)
Bipolar plates represent an important part of the fuel cell construction set-up. They contribute significantly also to the fuel cells stack production costs. This is because of corossion aggressiveness of their working environment and related material demands. Target of this project is to develop alternative approach based on utilisation of steel based plates surface modified by suitable composite. Inseparable part of the project is CFD modelling of the reactants and products flow in the flow field geometry targeted to optimise their structure.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

Development of 3D cell cultures for the evaluation of drug delivery systems

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)

Study Programme:

Faculty of Chemical Engineering

Development of 3D cell cultures for the evaluation of drug delivery systems

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Faculty of Environmental Technology

Digitization of water infrastructure: Development of a digital twin wastewater treatment plant

Bartáček Jan, doc. Ing. Ph.D. ( jan...@vscht.cz)
As in other sectors, the main aspects of Industry 4.0 are increasingly being used in water management: digitization, maximum use of data, use of artificial intelligence to obtain predictive data, etc. In particular, data (on water consumption, wastewater quantity and quality, etc.) have become one of the most valuable commodities of water management and their importance will undoubtedly grow in the coming years.
The main topic of this dissertation will be the development of a digital twin of a real wastewater treatment plant (WWTP). This tool consists of a detailed database of all WWTP facilities, incl. data on operation and maintenance and energy intensity, the on-line connection of sensors, the unification of data flow, and detailed spatial description of the entire WWTP. The main goal is the ability of predictive evaluation of WWTP operation optimizations.

Bioinformatics

Study Programme:

Faculty of Chemical Technology

Does the lack of sex affect our genomes and phenotypes? The impact of asexual reproduction on genomes, populations and fitness of clonal individuals.

Pačes Jan, Mgr. Ph.D. ( hpa...@img.cas.cz)
Development principles: V rámci projektu se student zapojí do mezinárodního teamu zaměřeného na výzkum klonálně se množících obratlovců.Cílem bude zjistit, jaký má klonování, tj. tvorba gamet bez klasické segregace a rekombinace, vliv na strukturu genomu a na fenotyp. V rámci terénní části práce pak bude student zkoumat typy prostředí, ve kterých se klonální jedinci uplatňují lépe, či hůře, než sexuálně se množící populace. Tato unikátní kombinace genotypových, fenotypových a ekologických dat nám umožní analyzovat podmínky, za kterých se patrně vyvinulo sexuální rozmnožování, a také zjistit v čem spočívá evoluční výhoda klonality.
In frame of the project, the student will join an international team investigating clonally reproducing vertebrates. He/she will evaluate the effect of cloning, i.e. gamete production without efficient recombination and segregation, on genome structure and phenotypes. During the field part of the project, the student will identify the types of environments where asexual individuals perform better than their sexually reproducing counterparts. Such a unique combination of genotypic, phenotypic and ecological data will enable unprecedented insight into the conditions under which sex might have evolved, and also the evolutionary potential of asexual reproduction.

Study Programme:

Faculty of Environmental Technology

Ecotoxicological evaluation of drugs and micropollutants present in the ecosystem

Říhová Ambrožová Jana, doc. RNDr. Ph.D. ( amb...@vscht.cz)
Wimmerová Lenka, Ing. MSc. Ph.D. ( wim...@dekonta.cz)
The topic of the work will focus on the research of new species of algal cultures for ecotoxicity testing. Part of the work will be the preparation of alginate beads from different algal strains and determining the toxicity response in comparison with "live" algal cultures. Ecotoxicological effects will be determined on model or real samples containing micropollutants (pharmaceuticals). Examples of substances to be evaluated will be triclosan, diclofenac, glyphosate, benzotriazole, etc., and less studied drugs.
Faculty of Chemical Technology

Effective properties of oxide and silicate ceramics and their dependence on composition, microstructure and temperature

Pabst Willi, prof. Dr. Dipl. Min. ( pab...@vscht.cz)
Uhlířová Tereza, Ing. Ph.D. ( ter...@vscht.cz)
This work concerns the effective properties of oxide and silicate ceramics, with a focus on the relations between composition, microstructure and elastic, thermophysical, thermoelastic, dielectric and piezoelectric properties. The student’s work includes the characterization of phase composition and grain size via X-ray diffraction, the microstructural characterization via microscopic image analysis, analytical calculations of effective properties via micromechanics (homogenization theory) for statistically isotropic and anisotropic (transversally isotropic) polycrystalline materials, analytical calculations and numerical modeling (computer simulation) of effective properties of multiphase materials (isotropic and transversally isotropic) and the comparison of theoretical predictions and the results and experimental measurements on real materials.
Faculty of Chemical Engineering

Effect of liquid physical properties on the mass transfer in various types of bioreactors

Zedníková Mária, Ing. Ph.D. ( zed...@vscht.cz)
Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
The production of new products in the field of biotechnology and pharmacy is often associated with a continuous change in the physical properties of liquids during the fermentation process. The physical properties of the batch mainly affect the mass transfer between gas and liquid and therefore they play a key role in the design of the bioreactor. The aim of the doctoral thesis is to study the mass transfer depending on the physical properties of used liquid media (viscosity, presence of various salts and surfactants) in the three types of the most commonly used bioreactors.
The work is intended as the cooperation of ICPF of the CAS (supervisor's workplace) and UCT Prague (consultant's workplace) appropriately complementing the second PhD topic offered by the consultant. Both cooperating workplaces are well equipped by necessary facilities i) stirred tank reactor, ii) bubble column and iii) air-lift reactor. All bioreactors are adapted to measure the volumetric mass transfer coefficient by the same methods, therefore the results will be comparable.
Requirements for an applicant: master degree in chemical or mechanical engineering, organic technology, biotechnology etc.; ability for teamwork; systematic and creative approach to scientific problems; interest in experimental work.
Development principles: 1. Perform the literary research on the topic dealing with the effect of liquid physical properties on the mass transfer in gas-liquid dispersion..
2. Learn the measurement techniques of liquid physical properties and of interfacial properties (dynamic surface tension, interfacial viscoelasticity). Learn the measurement technique of volumetric mass transport coefficient by dynamic pressure method.
3. Perform the systematic measurements of volumetric mass transport coefficient for defined liquids in three types of bioreactors: stirred tank reactor, bubble column and air-lift reactor.
4. Based on the obtained results, evaluate the effect of various liquid properties on the mass transfer in the gas-liquid dispersion.
Faculty of Chemical Engineering

Effect of liquid physical properties on the mass transfer in various types of bioreactors

Zedníková Mária, Ing. Ph.D. ( zed...@vscht.cz)
Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
The production of new products in the field of biotechnology and pharmacy is often associated with a continuous change in the physical properties of liquids during the fermentation process. The physical properties of the batch mainly affect the mass transfer between gas and liquid and therefore they play a key role in the design of the bioreactor. The aim of the doctoral thesis is to study the mass transfer depending on the physical properties of used liquid media (viscosity, presence of various salts and surfactants) in the three types of the most commonly used bioreactors.
The work is intended as the cooperation of ICPF of the CAS (supervisor's workplace) and UCT Prague (consultant's workplace) appropriately complementing the second PhD topic offered by the consultant. Both cooperating workplaces are well equipped by necessary facilities i) stirred tank reactor, ii) bubble column and iii) air-lift reactor. All bioreactors are adapted to measure the volumetric mass transfer coefficient by the same methods, therefore the results will be comparable.
Requirements for an applicant: master degree in chemical or mechanical engineering, organic technology, biotechnology etc.; ability for teamwork; systematic and creative approach to scientific problems; interest in experimental work.
Development principles: 1. Prostudujte odbornou literaturu na téma vliv fyzikálních vlastností kapaliny na přenos hmoty v disperzi kapalina-plyn.
2. Osvojte si techniky měření fyzikálních vlastností kapalin a vlastností mezifázového povrchu (dynamické povrchové napětí, viskoelasticita povrchu). Osvojte si techniku měření objemového koeficientu přenosu hmoty dynamickou tlakovou metodou.
3. Proveďte systematická měření objemového koeficientu přestupu hmoty pro definované vsádky ve třech typech bioreaktorů: mechanicky míchaný reaktor, probublávaná kolona a air-lift reaktor.
4. Na základě získaných výsledků vyhodnoťte vliv různých fyzikálních vlastností na přenos hmoty v disperzi kapalina plyn.
Faculty of Food and Biochemical Technology

Effect of thermal processes on fiber composition and nutritional value of biscuits

Sluková Marcela, doc. Ing. Ph.D. ( Mar...@vscht.cz)
Jurkaninová Lucie, Ing. et Ing. Ph.D.
Fiber content is one of the important qualities of cereals. The presence of dietary fiber in the diet stimulates intestinal peristalsis, reduces the absorption of lipids, cholesterol and sugars. Technological food processing influences the content, bioavailability, nutritional quality and physicochemical properties of the dietary fiber. On the contrary, the addition of dietary fiber influences the technology and consequently the sensory quality of the food product. The role of dietary fiber is to contribute to a general microstructure of fiber-enriched foods. The thesis will focus on evaluation of influence of thermal processes used in the secondary processing of cereals on dietary fiber, and the bioactive substances accompanying fiber in the outer layers of grains. The theoretical part will devote to the definition, methods of determining and the health effects of dietary fiber and a description of technological operations, mainly thermal processes used in the production of biscuits and breakfast cereal products, which will be devoted to the experimental part of the work. Besides the traditional materials used in bakery technology also new specially milled flours and flours from unconventional sources as barley or buckwheat will test.
Faculty of Chemical Engineering

Elaboration of environmentally benign composites for shielding of electromagnetic interference

Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
Kopecký Dušan, doc. Ing. Ph.D. ( kop...@vscht.cz)
The project deals with design of environmentally benign composites in form of flexible free-standing films for electromagnetic interference (EMI) shielding application. The composites will be prepared from bio-sourced cellulose fillers and efficient receptors of EMI (e.g. supramolecular conducting polymers, carbon nanotubes, graphene, etc.) Novel approaches of matrix/receptor compatibilization will be designed. In addition, fundamental aspects governing the behavior of the composites will be studied to understand the interactions occurring between the phases of the composites and the structure-properties relationships. Thorough experiments in the DC and AC electrical field on the composites and their components will be performed to reveal patterns driving the resulting shielding efficiency. Finally, the synergetic effect of both receptors leading to the controllable EMI shielding efficiency by absorption or reflection will be studied.
Faculty of Chemical Engineering

Elaboration of environmentally benign composites for shielding of electromagnetic interference

Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
Kopecký Dušan, doc. Ing. Ph.D. ( kop...@vscht.cz)
The project deals with design of environmentally benign composites in form of flexible free-standing films for electromagnetic interference (EMI) shielding application. The composites will be prepared from bio-sourced cellulose fillers and efficient receptors of EMI (e.g. supramolecular conducting polymers, carbon nanotubes, graphene, etc.) Novel approaches of matrix/receptor compatibilization will be designed. In addtion, fundamental aspects governing the behavior of the composites will be studied to understand the interactions occurring between the phases of the composites and the structure-properties relationships. Thorough experiments in the DC and AC electrical field on the composites and their components will be performed to reveal patterns driving the resulting shielding efficiency. Finally, the synergetic effect of both receptors leading to the controllable EMI shielding efficiency by absorption or reflection will be studied.
Faculty of Chemical Engineering

Elaboration of environmentally benign composites for shielding of electromagnetic interference

Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
Kopecký Dušan, doc. Ing. Ph.D. ( kop...@vscht.cz)
The project deals with design of environmentally benign composites in form of flexible free-standing films for electromagnetic interference (EMI) shielding application. The composites will be prepared from bio-sourced cellulose fillers and efficient receptors of EMI (e.g. supramolecular conducting polymers, carbon nanotubes, graphene, etc.) Novel approaches of matrix/receptor compatibilization will be designed. In addition, fundamental aspects governing the behavior of the composites will be studied to understand the interactions occurring between the phases of the composites and the structure-properties relationships. Thorough experiments in the DC and AC electrical field on the composites and their components will be performed to reveal patterns driving the resulting shielding efficiency. Finally, the synergetic effect of both receptors leading to the controllable EMI shielding efficiency by absorption or reflection will be studied.
Faculty of Chemical Technology

Elastic, dielectric and piezoelectric properties of ceramics and composites

Pabst Willi, prof. Dr. Dipl. Min. ( pab...@vscht.cz)
Uhlířová Tereza, Ing. Ph.D. ( ter...@vscht.cz)
Elastic, dielectric and piezoelectric properties are of fundamental importance for many types of functional ceramics and composites. Figures of merit for these materials, e.g. ceramics for hydrophone applications, are usually determined by a complex interplay of these three types of properties. This PhD topic focuses on the study of the dependence of the effective elastic, dielectric and piezoelectric properties on the microstructure, mainly porosity, pore shape and grain size (in the case of composites also volume fraction). The student is required to have a background in materials science (not necessarily specialized on ceramics) and an interest in challenging theory (full tensor formalism for second-, third- and fourth-order tensors), computer modeling and experimental work with real-world materials.
Faculty of Chemical Technology

Electrochemical methods for process water treatment

Paidar Martin, doc. Ing. Ph.D. ( pai...@vscht.cz)
Electrochemical methods are suitable for water treatment due its simplicity and high efficiency. Main disadvantage is usually high price. Therefore electrochemical methods are used in the case of water of high salinity or otherwise contaminated. This is not possible to be treated by biochemical methods. Application of individual method has to be evaluated with respect to the direct process water composition.
Faculty of Chemical Technology

Electrochemical methods for process water treatment

Paidar Martin, doc. Ing. Ph.D. ( pai...@vscht.cz)
Electrochemical methods are suitable for water treatment due its simplicity and high efficiency. Main disadvantage is usually high price. Therefore electrochemical methods are used in the case of water of high salinity or otherwise contaminated. This is not possible to be treated by biochemical methods. Application of individual method has to be evaluated with respect to the direct process water composition.
Faculty of Chemical Technology

Electrochemical synthesis of hypervalent iodine compounds as highly selective organic oxidants

Bystroň Tomáš, doc. Ing. Ph.D. ( bys...@vscht.cz)
A highly selective oxidations of organic compounds belongs, especially in the case of highly added value products, among highly attractive processes. At present, such conversions are usually achieved using oxidation agents based on often toxic transition metals such as Cr(VI), Mn(VII), Ru(VI) či Os(VIII). An interesting „green“ alternatives to these oxidants represent benign hypervalent iodine based organic oxidation agents. The work will be focused on investigation of electrochemical behaviour of these compounds and their precursors. A motivation of the work is to use electrochemical oxidation for the production of hypervalent iodine oxidants allowing their application as industrial scale.
Faculty of Chemical Technology

Electrochemical synthesis of hypervalent iodine compounds as highly selective organic oxidants

Bystroň Tomáš, doc. Ing. Ph.D. ( bys...@vscht.cz)
A highly selective oxidations of organic compounds belongs, especially in the case of highly added value products, among highly attractive processes. At present, such conversions are usually achieved using oxidation agents based on often toxic transition metals such as Cr(VI), Mn(VII), Ru(VI) či Os(VIII). An interesting „green“ alternatives to these oxidants represent benign hypervalent iodine based organic oxidation agents. The work will be focused on investigation of electrochemical behaviour of these compounds and their presursors. A motivation of the work is to use electrochemical oxidation for the production of hypervalent iodine oxidants allowing their application as industrial scale.
Faculty of Chemical Technology

Environmental accessibility of selenium in power plant fly ashes

Doušová Barbora, doc. Ing. CSc. ( dou...@vscht.cz)
Selenium belongs both to esential and toxic elements, where the boundary between them is very thin. Power plant fly ashes deposited in landfills represent an important antrhropognic sourse of selenium. The stability of selenium in fly ashes is primarily affected by the quality of burned coal and actual combustion technology. In addition, the age of fly ash and the geochemistry of landfill area can play important role in selenium mobility at the place of its occurrence. The aim of the PhD Thesis will be to characterize the structure, mineralogical and chemical composition and surface properties of different types of fly ash. The next step will be to determine the amount and major forms of Se in fly ash (by sequential leaching), and to study their stabilty and interaction with surrounding environment, i.e. with soils, sediments, surface water and groundwater. The obtained results should help to estimate the gradient of environmental availability of selenium, together with its potential ecological risk.
Faculty of Environmental Technology

Environmental impacts of alternative retail methods

Kočí Vladimír, doc. Ing. Ph.D., MBA ( k...@vscht.cz)
The PhD thesis will deal with the assessment of the environmental impacts of food distribution in the so-called unwrapped shop. Using the LCA method, the usual way of food packaging and the so-called zero waste system will be compared. The aim of the diploma thesis will be to determine the environmental impacts of individual types of purchasing, identify the phases or processes causing the greatest environmental impacts, design material optimization of systems and assess various ways of handling packaging at the end of its life. Primary data regarding the production of cups will be obtained in cooperation with Penny Market.
Development principles: Vypracujte literární rešerši zaměřenou na studované tema. Vytvořte model životního cyklu studovaných systémů nakupování.Vhodným způsobem zvolte funkční jednotku. Vytvořte inventarizační tabulku a zhodnoťte množství surovin a emisí souvisejících s životním cyklem daného systému. Vytvořte charakterizační profil posuzovaných systémůa vzájemně je srovnejte. Získané informace interpretujte.
Faculty of Food and Biochemical Technology

Enzymes and biologically active molecules as effective components of biopesticides

Halecký Martin, doc. Ing. Ph.D. ( mar...@vscht.cz)
In order to replace synthetic pesticides, recently, biopesticides based on enzymes and/or secondary metabolites of microorganisms have come to the forefront. Biopesticides are one of the main pillars of modern environmentally oriented approaches in (intensive) agriculture based on the prevention of environmental pollution. Such an environmentally friendly product should be designed as a mixture of biologically active molecules, thanks to which it has unique properties and complex effect. The genus Pseudomonas (e.g. Pseudomonas gessardii) appears to be a promising producer of biologically active molecules based on enzymes (chitinolytic enzymes), antibiological agents (pigments) or adjuvants (siderophores). From a technological point of view, the genus is a suitable producer that does not require demanding cultivation processes and expensive cultivation media. The research includes screening of suitable producers, comprehensive description of their properties and production of promising substances and design of suitable cultivation methods and bioreactors to produce active components of biopesticides.
Faculty of Food and Biochemical Technology

Epiphytic and endophytic microorganisms of hops and their biotechnological potential

Patáková Petra, prof. Dr. Ing. ( pat...@vscht.cz)
The work will focus on the isolation and identification of microorganisms from various parts of the hop plant and on further investigation of selected isolates. Attention will be focused on the search for bioactive substances that could be used as growth stimulators or inhibitors of fungal growth in hop growing. Furthermore, the influence of selected isolates on hop storage and beer production will be monitored. The outputs of the work will be directed to both basic research (microflora mapping) and the application sphere (development of bio-spraying for plants based on plant probiotics). Various methods will be used in the work, from classical culture microbiological techniques, through MALDI and 16SrRNA identification of isolates (in selected cases, possibly sequencing of the whole genome in the case of bacteria) to various chromatographic techniques and methods of testing biological activity.
Faculty of Chemical Technology

Equilibrium and kinetics in mechanochemical processes

Krupička Martin, Ing. Ph.D. ( mkz...@gmail.com)
Synthetic organic mechanochemistry studies reactions induced by mechanical force, most importantly in ball mills. The experimental conditions are substantially different from the usual chemistry in solution. This allows studying the chemical processes equilibria and kinetics also under extreme conditions. The goal of the work is the application of mechanochemical procedures on organic transformations and reaction condition optimization.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

Erosion-controlled drug release from super-placebo tablets

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
The rate of drug release from a pharmaceutical tablet is one of its most important quality attributes. As an ever-increasing number of Active Pharmaceutical Ingredients (APIs) are developed in alternative solid-state forms such as metastable polymorphs, co-crystals or amorphs, it is desirable to control the rate of drug release by the properties of the tablet matrix rather than by the properties of the API itself. The aim of this project is to explore the so-called “super-placebo” concept, i.e. tablets that erode in a defined way which is independent of the API they contain. The project will systematically explore the relationship between the rate of tablet erosion, the proportion of soluble and insoluble excipients (e.g. mannitol, microcrystalline cellulose), and the manufacturing process parameters (e.g. compaction pressure). The ability to control drug release rate will be demonstrated using several real-world APIs. Advanced instrumental methods such as Magnetic Resonance Imaging, x-ray micro CT and high-speed video-imaging will be used in order to gain a deep understanding of the underlying tablet erosion mechanisms.

Study Programme:

Faculty of Chemical Engineering

Erosion-controlled drug release from super-placebo tablets

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
The rate of drug release from a pharmaceutical tablet is one of its most important quality attributes. As an ever-increasing number of Active Pharmaceutical Ingredients (APIs) are developed in alternative solid-state forms such as metastable polymorphs, co-crystals or amorphs, it is desirable to control the rate of drug release by the properties of the tablet matrix rather than by the properties of the API itself. The aim of this project is to explore the so-called “super-placebo” concept, i.e. tablets that erode in a defined way which is independent of the API they contain. The project will systematically explore the relationship between the rate of tablet erosion, the proportion of soluble and insoluble excipients (e.g. mannitol, microcrystalline cellulose), and the manufacturing process parameters (e.g. compaction pressure). The ability to control drug release rate will be demonstrated using several real-world APIs. Advanced instrumental methods such as Magnetic Resonance Imaging, x-ray micro CT and high-speed video-imaging will be used in order to gain a deep understanding of the underlying tablet erosion mechanisms.
Faculty of Environmental Technology

Evaluation of Environment Protection Policies

Kočí Vladimír, doc. Ing. Ph.D., MBA ( k...@vscht.cz)
Potluka Oto, doc. Ing. Ph.D. ( pot...@vscht.cz)
The dissertation thesis is focused on the impact evaluation of environmental policies and interventions. Methodologicaly, rigorous evaluation methods will be used.
Development principles: Identifikujte klíčové faktory ovlivňující úspěšnost politik orientovaných na ochranu životního prostředí. Při identifikaci je nezbytné respektovat specifika typu politik, geografický rozsah, a typ znečištění. Při hodnocení aplikujte rigorózní metody testování a respektujte možnou roli více proměnných s respektováním faktorů týkajících se ochrany životního prostředí.
Metodologie: analýza sekundárních pramenů z Web of Science a Scopus, datové podkady ČSÚ, Eurostat, European Environment Agency; metody primárního výzkumu: dotazníkový průzkum, polostrukturované a nestrukturované rozhovory, testování, návrh testovaného modelu
Faculty of Food and Biochemical Technology

Evaluation of food safety from the point of view of newly occurring groups of mycotoxins

Stránská Milena, doc. Ing. Ph.D. ( zac...@vscht.cz)
Mycotoxins are toxic secondary metabolites of microscopic filamentous fungi occurring naturally on agricultural plants / crops. Today, hundreds of these substances are known, and their structure and biological effects differ depending on the type of their producer, the type of colonized plant, and environmental conditions. As chemically and thermally stable substances, they are being transferred into food and feed to a relatively large extent and can pose a health risk for consumers. Nowadays, the health risks of only a small fraction of these substances have been assessed, so data on the occurrence of new groups of mycotoxins, occurrence of which is related to ongoing climate change, are highly desirable and necessary for the risk assessment. The topic of the dissertation thesis reflects the need to obtain new information on the occurrence of mycotoxins (specified also by the European Food Safety Authority), and will include the development of new modern analytical methods based on liquid chromatography and mass spectrometry, and their implementation in screening and quantification of a wide range of mycotoxins in food and feed.
Faculty of Food and Biochemical Technology

Evaluation of food safety from the point of view of newly occurring groups of mycotoxins

Stránská Milena, doc. Ing. Ph.D. ( zac...@vscht.cz)
Mycotoxins are toxic secondary metabolites of microscopic filamentous fungi occurring naturally on agricultural plants / crops. Today, hundreds of these substances are known, and their structure and biological effects differ depending on the type of their producer, the type of colonized plant, and environmental conditions. As chemically and thermally stable substances, they are being transferred into food and feed to a relatively large extent and can pose a health risk for consumers. Nowadays, the health risks of only a small fraction of these substances have been assessed, so data on the occurrence of new groups of mycotoxins, occurrence of which is related to ongoing climate change, are highly desirable and necessary for the risk assessment. The topic of the dissertation thesis reflects the need to obtain new information on the occurrence of mycotoxins (specified also by the European Food Safety Authority), and will include the development of new modern analytical methods based on liquid chromatography and mass spectrometry, and their implementation in screening and quantification of a wide range of mycotoxins in food and feed.
Faculty of Environmental Technology

Evaluation of Results and Impacts of Stakeholders Participation in Design and Implementation of Environment Protection Policies

Kočí Vladimír, doc. Ing. Ph.D., MBA ( k...@vscht.cz)
Potluka Oto, doc. Ing. Ph.D. ( pot...@vscht.cz)
The dissertation thesis is focused on the results and impact of stakeholders´ participation on design and implementation of environmental policies and interventions. In the analysis, the thesis should apply networked governance, application of place-based leadership, co-creation, co-production, or partnership.
Development principles: Vytvořte modely pro hodnocení výsledků a dopadů vybraných opatření politik ochrany životního prostředí dle zapojení relevantních aktérů.
Metodologie: analýza sekundárních pramenů z Web of Science a Scopus, datové podkady ČSÚ, Eurostat, European Environment Agency; metody primárního výzkumu: dotazníkový průzkum, polostrukturované a nestrukturované rozhovory, testování, návrh testovaného modelu.
Faculty of Food and Biochemical Technology

Evaluation of vitamins' levels in human biological samples

Pulkrabová Jana, prof. Ing. Ph.D. ( jan...@vscht.cz)
Drábová Lucie, Ing. Ph.D. ( dra...@vscht.cz)
In this dissertation, analytical methods for the determination of lipophilic vitamins (A, D, E) and vitamin C in human biological samples such as breast milk and blood serum will be will be developed. The methods will be used to evaluate the levels of vitamins in breast milk. These vitamins are important for lung development and for brain development. According to published data, concentration of these vitaminas may be insufficiently in breast milk and it is often difficult to supplement the required vitamins in oral form in premature newborns. Therefore, in the next phase, substitution will be tested by oral intake to the mother and subsequent production into milk. The study will be carried out in cooperation with the hospital in České Budějovice. The project will monitor the concentration of vitamins A, D, E, C, omega 3 and omega 6 fatty acids in the mother's blood, milk and newborn's blood. Distribution of substances among these biological fluids will be evaluated. The study will provide very important data in the field of nutrition of premature babies.
Faculty of Chemical Engineering

Experimental study of morphology formation for polymers and polymer films

Kosek Juraj, prof. Dr. Ing. ( Jur...@vscht.cz)
Zubov Alexandr, Ing. Ph.D. ( Ale...@vscht.cz)
This PhD project will focus on the morphology evolution in selected polymeric systems: (i) semi-crystalline polyolefins including high-impact polypropylene, (ii) films formed from polymer latexeses. Morphology of polymers predetermines their application (i.e., mechanical, optical and transport) properties. The goal of this project is the experimentally-based analysis of the detailed mechanism of morphology formation by using of numerous visualization techniques (AFM, SEM/TEM, micro-CT, confocal Raman, SAXS, DSC, TD-NMR, ...).

One of difficult tasks is the morphology visualization of semi-crystalline polyolefins (lamellae ~ 10 nm) organized into super-structures (~ 100 až 1000 nm). The difficulty of this task is given by sometimes ambiguous interpretation of various visualization techniques and by not yet well-developed methodology of morphology descriptors. The new problematics will be the formation of films from polymer latexes by processes of: (i) evaporation, concentration and ordering of colloid particles, (ii) particle deformation, (iii) difusion of polymer chains. The goal is the morphology characterization in various stages between the original latex and the final compact film.

Polymer morphology is the consequence of various processes driven by phase-separation thermodynamics including crystallization, by the kinetics of crystallization, by diffusion and osmotic processes, by interactions involving capillary effects and surface tension, and by electrostatic and van der Waals interactions. Consequences of these and further morphology-forming processes can be correctly interpreted only by both theoretically and practically prepared PhD student.

The results of this challenging PhD project will be not only high-quality papers, but also expert in many fields of polymer and material engineering. Experiences gained during this project will be broadly applicable also for other polymers, metail and wood materials, biology systems, ceramics, food and personal care products etc.

Info: phone +420 220 44 3296, room B-145, e-mail jkk@vscht.cz, web http://kosekgroup.cz
Faculty of Food and Biochemical Technology

Fermentation production of bio-hydrogen using clostridia

Patáková Petra, prof. Dr. Ing. ( pat...@vscht.cz)
Hydrogen offers various uses, in direct combustion without the formation of CO2, as a reducing agent for chemical reactions or as one of the precursors of methane production. The work will focus on the study of hydrogen production in Clostridial fermentation using both pure cultures and consortia of microorganisms. The outputs of the work will be directed both to basic research (study of hydrogenases and finding the exact mechanism of hydrogen production in Clostridium beijerinckii) and to the application sphere (utilization of various types of waste for hydrogen production and other metabolites, which will then be led to the biogas plant and used to strengthen methanation ). The work assumes routine mastery of various techniques, such as bioreactor cultivation, analysis of gaseous and liquid metabolites, study of gene transcription using RT-qPCR techniques, microscopy and others.
Faculty of Food and Biochemical Technology

Fish identification: molecular-biological and proteomic approaches

Demnerová Kateřina, prof. Ing. CSc. ( dem...@vscht.cz)
Zdeňková Kamila, Ing. Ph.D. ( zde...@vscht.cz)
Food market is still broadened with new products from different producers and suppliers, which increases the diversity of consumers' menus on one hand, but therewithal it creates conditions for food fraud on the other hand. Food fraud may be associated also with health hazards for consumers. The consumers´ misleading can be done e.g. by replacing more expensive raw materials with cheaper ones, failing in complying the declared composition or by deliberately mislabelling the geographical origin or the production method. One category of often-falsified food are fish, fish products and seafood, which are also associated with the occurrence of significant allergens. The work aims to develop and experimentally verify methodologies for the identification of fish using DNA and protein analysis. Molecular-biological methods should allow such species determination within the class of Actinopterygii, and will comprise modern methods such as polymerase chain reaction (PCR, qPCR, and dPCR) and sequencing. The target gene to be analysed is the gene encoding the main fish allergen, parvalbumin. The proteins analysis will be aimed at comparing proteins profiles obtained by mass spectrometry MALDI-TOF.
Faculty of Chemical Engineering

Fluid separations in the modern era challenges

Rejl František, doc.Ing. Ph.D. ( r...@vscht.cz)
Fluid separation processes are widely used and time proven large-capacity separation processes (eg absorption, extraction, distillation). Many new technologies (electric cars, new light sources, geothermal energy sources, etc.) are currently gaining market share and corresponding need for recycling and waste management leads to the necessity of the development of the new high capacity separation technologies. The work should lead to the development/refinement of the selected separation technology in cooperation with an industrial partner.
Faculty of Food and Biochemical Technology

Food safety - contamination from food contact materials

Rajchl Aleš, doc. Ing. Ph.D. ( ale...@vscht.cz)
Vápenka Lukáš, Ing. Ph.D. ( VAP...@vscht.cz)
The study will be focussed on identification a quantification of selected contaminants in food contact materials and on quantification of the level of their migration into food. The work will include the development of suitable analytical procedure for contaminant determination and safety assessment related to present contaminants.
Faculty of Food and Biochemical Technology

Food safety - contamination from food contact materials

Rajchl Aleš, doc. Ing. Ph.D. ( ale...@vscht.cz)
Vápenka Lukáš, Ing. Ph.D. ( VAP...@vscht.cz)
The study will be focussed on identification a quantification of selected contaminants in food contact materials and on quantification of the level of their migration into food. The work will include the development of suitable analytical procedure for contaminant determination and safety assessment related to present contaminants.
Faculty of Chemical Engineering

Formation of Micro and Nanostructured Heat Insulation Materials

Kosek Juraj, prof. Dr. Ing. ( Jur...@vscht.cz)
Zubov Alexandr, Ing. Ph.D. ( Ale...@vscht.cz)
The aim of this project is the optimization of insulation properties of available materials and the development of a new generation of insulation materials based on experimental and theoretical knowledge about formation of micro- and nanostructured materials. These materials would dramatically lower the energy consumption for heating and conditioning of buildings.

Micro- and nanostructured materials can be prepared in different ways. The Ph.D. student will focus mainly on the following preparation methods: (i) laser and (ii) pressure induced foaming, and (iii) thermally induced phase separation. The laser induced foaming is a novel method, which enables to observe early stages of formation of micro- and nanostructured materials. The knowledge about the formation of these materials is insufficient and therefore micro- and nanostructured material with several-fold improved heat insulation properties are not still mass produced.

Pressure induced foaming enables to optimize current materials and it uses supercritical CO2 instead of common organic blowing agents. The method of thermally induced phase separation enables to prepare different structure of micro- and nanostructured materials. This opens new application possibilities for micro- and nanostructured materials.

Ph.D. student will be supported by well-equipped laboratories for structural analysis of materials (optical microscope, micro-CT, SEM, AFM, Hg porosimeter, He pycnometer, BET, confocal Raman) including devices to study sorption, transport and heat insulation properties. The student will cooperate with the Institute of Chemical Process Fundamentals of the Czech Academy of Science and New Technologies Research Centre – University of West Bohemia, and will be sent for a research stay into one of our European cooperation centres. This work is supported with grants and industrial cooperations.

Info: phone 220 44 3296, office B-145, e-mailjkk@vscht.cz, web http://kosekgroup.cz
Faculty of Chemical Engineering

Formulation and bioavailability of natural poly-actives

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Current paradigm in pharmaceutical drug development and its regulatory environment is based on the concept of Active Pharmaceutical Ingredient (API) as a well-defined single molecular entity that is contained in the dosage form at a precise quantity and chemical purity. Although rational in many ways, this approach is rather different from evolution-proof substances found in Nature. The main drawback is single-API medicines is the development of drug resistance over historically extremely short time periods (only a few decades), which is problematic not only in the area of antibiotics but also in cancer treatment, anti-fungal and various anti-parasitic drugs that gradually lose their effectiveness. In contrast, there are examples of natural systems that maintain their efficacy for many millennia. Perhaps the most prominent example of such material is bee propolis. Chemically, propolis is a mixture of several hundred chemical species with location- and season-dependent composition, which would completely disqualify it as a registered medicinal substance. However, it is exactly this variable multi-component character that makes is so robust and durable, not giving pathogens a chance to develop resistance. Propolis contains both water-soluble and water-insoluble components and is typically applied as ethanol dispersion only for surface treatment. The aim of this project is to explore formulation approaches that could enable oral administration of propolis and ensure its safety and bioavailability. The project is multidisciplinary and will include not only formulation and analytical work, but also in vitro and in vivo testing of biological efficacy.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

Formulation and bioavailability of natural poly-actives

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Current paradigm in pharmaceutical drug development and its regulatory environment is based on the concept of Active Pharmaceutical Ingredient (API) as a well-defined single molecular entity that is contained in the dosage form at a precise quantity and chemical purity. Although rational in many ways, this approach is rather different from evolution-proof substances found in Nature. The main drawback is single-API medicines is the development of drug resistance over historically extremely short time periods (only a few decades), which is problematic not only in the area of antibiotics but also in cancer treatment, anti-fungal and various anti-parasitic drugs that gradually lose their effectiveness. In contrast, there are examples of natural systems that maintain their efficacy for many millennia. Perhaps the most prominent example of such material is bee propolis. Chemically, propolis is a mixture of several hundred chemical species with location- and season-dependent composition, which would completely disqualify it as a registered medicinal substance. However, it is exactly this variable multi-component character that makes is so robust and durable, not giving pathogens a chance to develop resistance. Propolis contains both water-soluble and water-insoluble components and is typically applied as ethanol dispersion only for surface treatment. The aim of this project is to explore formulation approaches that could enable oral administration of propolis and ensure its safety and bioavailability. The project is multidisciplinary and will include not only formulation and analytical work, but also in vitro and in vivo testing of biological efficacy.

Study Programme:

Faculty of Chemical Technology

Fullerene complexation using higher calixarenes/thiacalixarenes

Lhoták Pavel, prof. Ing. CSc. ( lho...@vscht.cz)
The aim of this work is the design and synthesis of higher calixarenes (calix[5]arene and higher) that could be applied as receptors for the fullerene recognition. The aim of this work is to achieve selective complexation of C60 or C70 using suitably chemically modified calixarene skeletons and concave/convex principle of the interactions. Novel compounds will be used as receptors for the complexation of fullerenes and as the building blocks for construction of supramolecular self-assembly systems.
Faculty of Chemical Technology

Fullerene complexation using higher calixarenes/thiacalixarenes

Lhoták Pavel, prof. Ing. CSc. ( lho...@vscht.cz)
The aim of this work is the design and synthesis of higher calixarenes (calix[5]arene and higher) that could be applied as receptors for the fullerene recognition. The aim of this work is to achieve selective complexation of C60 or C70 using suitably chemically modified calixarene skeletons and concave/convex principle of the interactions. Novel compounds will be used as receptors for the complexation of fullerenes and as the building blocks for construction of supramolecular self-assembly systems.
Faculty of Food and Biochemical Technology

Functional,- structural characterization of the NMDA receptor channel

Rumlová Michaela, doc. Dr. Ing. ( Mic...@vscht.cz)
N-methyl-D-aspartate (NMDA) receptors are a type of ionotropic glutamate receptors mediating fast synaptic transmission and are essential for learning and memory. Abnormal function of NMDA receptors underlies many neurological and psychiatric diseases, including schizophrenia and neurodegenerative disorders. We use advanced electrophysiology, molecular biology, optogenetics, and microscopy to investigate the relationship between the structure and the function of NMDA receptor ion channels, to characterize molecular mechanisms of action of different pharmacological agents influencing them, and to study the physiological and pathological processes in which NMDA receptors participate.
The aim of the PhD project is to characterize functional consequences of de-novo and other mutations found in individuals diagnosed with schizophrenia, mental retardation, autism, or epilepsy for the function of the NMDA receptor and to rectify impaired function by newly synthetized steroid compounds. Disease-associated mutations will be studied in recombinant NMDA receptors expressed in HEK cells and native receptors in cultured hippocampal neurons derived from GMO mice. The project will include the characterization of consequences of mutations for synaptic transmission and behavior, both under normal conditions and in mouse and zebrafish models of neurological and psychiatric disorders.


Cultured hippocampal neuron; negative and positive allosteric effect of neurosteroids; structure of NMDA receptor.
Faculty of Chemical Engineering

Gas and liquid transport study in graphene oxide and carbon nanotubes based membranes

Friess Karel, doc. Ing. Ph.D. ( fri...@vscht.cz)
Membrane separation processes (MSP) belong to the modern technologically significant separation methods. Furthermore, MSP are less economical demanding and more eco-friendly industrial processes compared to the conventional separation techniques used in chemical, petrochemical, pharmaceutical and food industries. The most significant industrial applications of MSP for gas separation are focused on separation of helium from natural gas, separation of hydrogen from hydrocarbons, carbon monoxide or nitrogen and also for removing carbon dioxide from biogas or organic vapors from air. Generally, graphene oxide (GO) based membrane materials belong to the modern and dynamically growing group of materials that have many interesting properties. Especially, this work will be targeted on GO based separation of hydrogen from carbon dioxide. Besides, the separation effect of prepared membranes will be tested for the selective removal of organic contaminants from the water. Our laboratory is focused on the topic of membrane separation for more than 15 years. Currently, we participate in two grant projects of the GA CR aimed at increasing the efficiency of membrane separation processes. This doctoral thesis is thematically linked to these projects.
Development principles: 1) Literature search 2) a] Performing of permation and sorption experiments of H2, CO2 and others selected gases (O2, N2, CH4, H2, He, Ar, SF6) in graphene oxide membranes, b] pertraction of water and water solutions of organic compounds 3) Evaluation and elaboration of determined experimental data and calculation of transport parameters (coefficients of permeability, diffusion and sorption) 4) PhD thesis writing

Chemical and Process Engineering

Study Programme:

Faculty of Chemical Engineering

Gas - Liquid Mass Transfer. Experimental comparison of various apparatuses performance.

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
The volumetric mass transfer coefficient (kLa) plays a crucial role in industrial design in the case of the process controlled by gas–liquid mass transfer. Prediction of kLa is nowadays mostly based on literature correlations. Our research goal is to establish suitable kLa correlations for different types of devices that would be based on the experimental dataset. The PhD thesis aim at the comparison of various gas-liquid contactor types from the viewpoint of their mass transfer efficiency. The suitable correlations will be developed that would be viable for mechanically agitated gas–liquid contactors and also for pneumatically agitated gas–liquid contactors such as airlift reactor.
Development principles: 1. Get familiar with mathematical descriptions of a gas-liquid interfacial mass transfer including mass balances of various gas-liquid contactor types
2. Study mathematical models of the mass transport which enable the determination of gas-liquid mass transfer coefficients from experimental data
3. Get to know the experimental apparatuses available at UNIPA in the working group of prof. Brucato and prof. Scargiali as well as those at UCT Prague in the Mass Transfer Laboratory
4. Build the experimental plan which will ensure obtaining experimental results to compare the effectivity of individual apparatuses according to the criteria selected
5. Theoretical findings, experimental procedures and results as well as the conclusions formulated write in the dissertation
Faculty of Chemical Engineering

Gas - Liquid Mass Transfer. Experimental comparison of various apparatuses performance.

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
The volumetric mass transfer coefficient (kLa) plays a crucial role in industrial design in the case of the process controlled by gas–liquid mass transfer. Prediction of kLa is nowadays mostly based on literature correlations. Our research goal is to establish suitable kLa correlations for different types of devices that would be based on the experimental dataset. The PhD thesis aim at the comparison of various gas-liquid contactor types from the viewpoint of their mass transfer efficiency. The suitable correlations will be developed that would be viable for mechanically agitated gas–liquid contactors and also for pneumatically agitated gas–liquid contactors such as airlift reactor.
Development principles: 1. Seznamte se s popisy mezifázového transportu hmoty mezi plynem a kapalinou včetně bilancí různých typů kontaktorů kapalina - plyn
2. Prostudujte matematické popisy procesu sdílení hmoty, které umožňují stanovení koeficientů přestupu hmoty z experimentálních dat
3. Seznamte se s dostupnými experimentálními zařízeními na UNIPA v pracovní skupině prof. Brucato a prof. Scargiali a na VŠCHT v Laboratoři SH
4. Sestavte plán experimentů, které poskytnou výsledky umožňující porovnání efektivity jednotlivých zařízení podle zvolených kritérií
5. Teoretické poznatky, experimentální postupy a výsledky sepište společně se závěry do podoby dizertační práce

Study Programme:

Faculty of Chemical Technology

Glazes with controlled reflectance

Kloužková Alexandra, doc.Ing. CSc. ( ale...@vscht.cz)
Ceramic materials are surface-treated by applying different types of coatings, the most common surface finishing of ceramic products are glazes- stable glassy coatings. By using suitable additives / pigments in glazes, the final properties of a ceramic product, such as roofing tilles, can be adjusted. The dissertation will focus on the preparation of glazing with controlled reflection of "cool roof" systems.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Technology

Growing Single Crystals and Structure Analysis of Multiple Component Crystals

Čejka Jan, Ing. Ph.D. ( cej...@vscht.cz)
API's multiple-component crystals are a valuable option in modfying pharmacokinetic profile, stability of API etc. The application properties of any particular active compound are often rendered by means of the component is built in the structure. This work aims to prepare single crystals of salts, solvates, co-crystals and polymorphs of selected compounds, study potentional temperature dependent phase transitions, their complex characterization using a bundle of analytical methods accenting X-ray structure analysis and consequent correlation of parameters and solvent occupied voids.
Faculty of Chemical Technology

Growing Single Crystals and Structure Analysis of Multiple Component Crystals

Čejka Jan, Ing. Ph.D. ( cej...@vscht.cz)
API's multiple-component crystals are a valuable option in modfying pharmacokinetic profile, stability of API etc. The application properties of any particular active compound are often rendered by means of the component is built in the structure. This work aims to prepare single crystals of salts, solvates, co-crystals and polymorphs of selected compounds, study potentional temperature dependent phase transitions, their complex characterization using a bundle of analytical methods accenting X-ray structure analysis and consequent correlation of parameters and solvent occupied voids.

Study Programme:

Faculty of Environmental Technology

Heavy metals removal from flue gas produced during combustion of coal

Ciahotný Karel, doc. Ing. CSc. ( cia...@vscht.cz)
Vagenknechtová Alice, Ing. Ph.D. ( ali...@vscht.cz)
The work is focused on testing of adsorbents suitable to the mercury removal from the flue gases produced by the brown coal combustion. The goal is to find the optimal adsorbents to allow effective removal of mercury from power plant flue gases produced by combustion of the Czech Brown, to estimate their adsorption capacities for mercury under the conditions of power plant flue gas adsorption (high temperature and high humidity) and the possibility of the eventual regeneration of saturated adsorbents. The work is part of the grant project TACR.
Faculty of Chemical Technology

Heterogeneous catalysis on self-assembled organic semiconductors

Kovaříček Petr, Ing. Ph.D. ( kov...@vscht.cz)
Catalysis enable production of multitude of daily use products by lowering the energy barrier towards the formation of the desired product. In a particular subfield of catalysis on semiconductors, light as the cleanest energy source is converted into individual charge carriers, which then consequently trigger the catalytic transformation. The aim of this work is achieve photocatalysis on self-assembled organic semiconductors. Designing de novo a catalyst is a tedious task which tackles the challenges in order as they appear during the development process. Instead, in this work, the principles of combinatorial/dynamic chemistry and guided evolution of complex systems will be exploited to let the systems solve these issues on its own by several self-processes (assembly, sorting, organization). The performance of the developed systems will be tested on a few selected model reactions and potential leading structures will be a subject of dedicated studies.
Faculty of Chemical Technology

Heterogeneous catalysis on self-assembled organic semiconductors

Kovaříček Petr, Ing. Ph.D. ( kov...@vscht.cz)
Catalysis enable production of multitude of daily use products by lowering the energy barrier towards the formation of the desired product. In a particular subfield of catalysis on semiconductors, light as the cleanest energy source is converted into individual charge carriers, which then consequently trigger the catalytic transformation. The aim of this work is achieve photocatalysis on self-assembled organic semiconductors. Designing de novo a catalyst is a tedious task which tackles the challenges in order as they appear during the development process. Instead, in this work, the principles of combinatorial/dynamic chemistry and guided evolution of complex systems will be exploited to let the systems solve these issues on its own by several self-processes (assembly, sorting, organization). The performance of the developed systems will be tested on a few selected model reactions and potential leading structures will be a subject of dedicated studies.
Faculty of Chemical Technology

High-entropy alloys prepared by powder metallurgy techniques

Průša Filip, Ing. Ph.D. ( Fil...@vscht.cz)
Since the year 2004, the materials research gained a new way of focusing on special alloys made initially of five elements with equiatomic compositions. The newly discovered group of materials has been since then known as high-entropy alloys (HEA) due to a high entropy of mixing which allows creating predominantly solid solutions instead of intermetallic phases. These materials are known to be exhibiting a variety of excellent properties that often combine high strengths while maintaining good ductility, good corrosion resistance and others. The work will aim at the description of the microstructure-related properties of high-entropy alloys prepared by powder metallurgy techniques combining mechanical alloying and compaction via spark plasma sintering.
Faculty of Chemical Engineering

High resolution spectroscopy in the THz and MW regions

Urban Štěpán, prof. RNDr. CSc. ( urb...@vscht.cz)
Kania Patrik, Ing. Ph.D. ( kan...@vscht.cz)
Faculty of Chemical Engineering

High-throughput development and continuous manufacturing of SMEDD systems

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Self micro-emulsifying drug delivery systems (SMEDDS) are formulations that spontaneously form a mini- or micro-emulsion upon contact with water. They typically contain the active pharmaceutical ingredient (API), a mixture of oils or low-melting lipids in which the API is soluble, and one or more surfactants and co-surfactants. SMEDDS are complex ternary or higher-order mixtures whose phase behaviour and properties are notoriously difficult to predict at present. Therefore, the development of SMEDDS is to a large extent an empirical process. Due to a large number of formulation components and their possible ratios, it is rarely possible to completely cover the entire design space, which may lead to sub-optimum formulations or even a false rejection of a particular API as non-formulatable. The aim of this project is to construct a device and develop a methodology for automatic combinatorial screening of SMEDDS formulations and their continuous manufacturing based on the so-called liquid marbles. The project will build on a recently developed patented device called “Marblemat” and extend its capabilities towards combinatorial mixing of formulation components and serial production of liquid marbles with systematically varying composition. Simultaneously, capability for high-throughput testing of the formulation properties such as mechanical strength, temperature stability and dissolution properties will be implemented and demonstrated on several industry-relevant APIs.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

High-throughput development and continuous manufacturing of SMEDD systems

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Self micro-emulsifying drug delivery systems (SMEDDS) are formulations that spontaneously form a mini- or micro-emulsion upon contact with water. They typically contain the active pharmaceutical ingredient (API), a mixture of oils or low-melting lipids in which the API is soluble, and one or more surfactants and co-surfactants. SMEDDS are complex ternary or higher-order mixtures whose phase behaviour and properties are notoriously difficult to predict at present. Therefore, the development of SMEDDS is to a large extent an empirical process. Due to a large number of formulation components and their possible ratios, it is rarely possible to completely cover the entire design space, which may lead to sub-optimum formulations or even a false rejection of a particular API as non-formulatable. The aim of this project is to construct a device and develop a methodology for automatic combinatorial screening of SMEDDS formulations and their continuous manufacturing based on the so-called liquid marbles. The project will build on a recently developed patented device called “Marblemat” and extend its capabilities towards combinatorial mixing of formulation components and serial production of liquid marbles with systematically varying composition. Simultaneously, capability for high-throughput testing of the formulation properties such as mechanical strength, temperature stability and dissolution properties will be implemented and demonstrated on several industry-relevant APIs.

Study Programme:

Faculty of Chemical Technology

Hydratation and adsorption properties of waste aluminosilicates in water management

Doušová Barbora, doc. Ing. CSc. ( dou...@vscht.cz)
Aluminosilicates, together with e.g. powdered building waste, biochar, lignin are able to adsorb and keep a large amount of water compare to soils and sediments. The mixing of these materials with selected soils in controlled dosages can support water retention in soils, which is significant due to more and more often "dry periods" and generally lower precipitation. A controlled dosage of the material with high water retention to soil ecosystems can improve markedly a water regime and hydrological cycle.
Faculty of Chemical Technology

Hydrogels based on poly(vinyl alcohol)

Slepičková Kasálková Nikola, Ing. Ph.D. ( Nik...@vscht.cz)
This work deals with the preparation and characterization of hydrogels films based on PVA. Hydrogels will be modificated physically (plasma, laser radiation) or/and chemically (doping with nanoparticles, drugs, dyes, etc.). Changes in surface and mechanical properties depending on the modification will be studied. The antibacterial properties and cytocompatibility of the prepared hydrogels will be determined.
Faculty of Environmental Technology

Hydrogenation of aldol condensation products

Kubička David, doc. Ing. Ph.D., MBA ( Dav...@vscht.cz)
The thesis will deal with hydrogenation of products obtained by aldol condensation of e.g. furfural with acetone or cyclohexanone. These products are highly functionalized which makes their selective conversion into components of aviation biofuels or bio-monomers highly challenging. The key aspect is the development of a stable and selective bifunctional catalyst that will allow obtaining high yields of desired hydrocarbons or diols. Main attention will be focused on synthesis, characterization and testing of catalysts with the aim to describe the relationship between catalyst’s composition and properties, on the one hand, and its activity and selectivity, on the other hand, and facilitate thus rational design of an optimum catalytic system.
Faculty of Environmental Technology

Hydrogenolysis of polyols over heterogeneous Cu catalysts

Kubička David, doc. Ing. Ph.D., MBA ( Dav...@vscht.cz)
Kocík Jaroslav, Ing. ( Jar...@unicre.cz)
Faculty of Chemical Engineering

Characterization and modelling of dispersion systems with variable viscosity

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
The goal of this project is to characterize and model systems where viscosity of the dispersed phase is rising during the process. Typical examples are emulsification, suspension polymerization or spherical agglomeration. The student will start with simplified system composed of two liquid phases with various viscosities, which will be analyzed by on-line sensors providing information about the droplets sizes. Experimental activity will cover both batch as well as continuous operation modes. Collected data will be consequently used to develop engineering model based on computational fluid dynamic of the fluid flow coupled with population balances to describe coalescence and breakup of dispersed phase for various levels of dispersed phase viscosity. An extension of this activity will be process of spherical agglomeration where dispersed phase will contain particles (nanoparticles or crystals), which can undergo agglomeration and thus increasing the viscosity of the dispersed phase. Developed model will be validated against experimental data collected at various scales or operating conditions.
Faculty of Chemical Engineering

Characterization and modelling of dispersion systems with variable viscosity

Šoóš Miroslav, prof. Ing. Ph.D. ( Mir...@vscht.cz)
The goal of this project is to characterize and model systems where viscosity of the dispersed phase is rising during the process. Typical examples are emulsification, suspension polymerization or spherical agglomeration. The student will start with simplified system composed of two liquid phases with various viscosities, which will be analyzed by on-line sensors providing information about the droplets sizes. Experimental activity will cover both batch as well as continuous operation modes. Collected data will be consequently used to develop engineering model based on computational fluid dynamic of the fluid flow coupled with population balances to describe coalescence and breakup of dispersed phase for various levels of dispersed phase viscosity. An extension of this activity will be process of spherical agglomeration where dispersed phase will contain particles (nanoparticles or crystals), which can undergo agglomeration and thus increasing the viscosity of the dispersed phase. Developed model will be validated against experimental data collected at various scales or operating conditions.
Faculty of Food and Biochemical Technology

Characterization and use of newly developed biodegradable and recyclable polymeric materials in biotechnology and other fields

Halecký Martin, doc. Ing. Ph.D. ( mar...@vscht.cz)
The research is carried out in cooperation with Institute of Macromolecular Chemistry of the AS CR, v.v.i., Prague, that designs advanced polyurethane materials with adjustable biodegradation rate. Polyurethanes are synthesized as polyester-ether polyols with different ether/ester segment ratios to achieve specific polymer structure density and suitable surface properties (hydrophobicity, charge) to improve microorganism adhesion and hydrolytic degradability. Research includes evaluation of individual polymeric materials in the context of intended use (e.g. as biofilm carrier in packed reactors, biodegradable fillers for product packaging, filaments for 3D printing) and analytical evaluation of four basic processes of biological action on polyurethane material: structural disruption (FTIR and Raman spectroscopy SEM), fragmentation (MALDI-TOF, HPLC-UV/RI, HPLC-MS and GC-MS), assimilation (Oxitop) and surface colonization (zeta potential, contact angle and image analysis). In case of interest, it is also possible to participate in the research of polymer synthesis at the Institute of Macromolecular Chemistry, thus, to set dissertation thesis as multidisciplinary.
Faculty of Food and Biochemical Technology

Characterization of natural raw materials and products by vibrational spectroscopic methods

Sinica Andrej, doc. Mgr. Ph.D. ( sin...@vscht.cz)
Bleha Roman, Ing. Ph.D. ( ble...@vscht.cz)
Vibration spectroscopic methods in combination with multivariate analysis will be used to characterize sets of model samples of raw materials of various origins, foodstuff, their chemical components (polysaccharides) or other products. The aim of the work will be to develop a procedure for sorting and evaluating the composition and quality of food raw materials and products using these methods including preparative approaches and sample preparations. The conclusions of vibrational spectroscopy will be substantiated and compared with the results obtained by common analytical methods.
Faculty of Environmental Technology

Characterization of sulphur compounds in petroleum middle distillates

Šimáček Pavel, doc. Ing. Ph.D. ( sim...@vscht.cz)
The thesis will deal with detailed characterization of sulphur compounds present in petroleum middle distillates using one-dimensional gas chromatography with selective detectors (flame photometric, pulsed flame photometric and sulphur chemiluminescence detectors) and using multidimensional comprehensive gas chromatography with mass spectrometry and sulphur chemiluminescence detectors. The aim of the work will be development and optimization of suitable analytical method and identification and determination of sulphur compounds present in petroleum middle distillates. Based on the experience gained, the possibilities of reducing the content of sulphur compounds in diesel fuel will be assessed by adjusting the conditions of hydrotreating and by adjusting of distillation cuts of individual diesel fuel components.
Faculty of Food and Biochemical Technology

Chemical and biochemical transformation of sucrose for production of other sugars and sugar alcohols

Sluková Marcela, doc. Ing. Ph.D. ( Mar...@vscht.cz)
Henke Svatopluk, Ing. Ph.D. ( sva...@vscht.cz)
Sucrose is a very good raw material for chemical and biochemical reactions. The sugar industry produces it in large quantities in a crystalline form of high purity, its production is stable and traditional, long-term storage and thus becomes a relatively cheap and well-defined reactant or substrate for further transformations. The work will be focused on the search for catalysed chemical, enzymatic or biological transformations of sucrose to common (glucose, fructose) or rare saccharides (psicose, tagatose, allosa, altrose, etc.) and sugar alcohols (mannitol, xylitol, erythritol, etc.). Various inorganic catalysts, enzyme groups, and microorganism strains will be used for the transformation to achieve high yield and concentration in the reaction mixture. The product will be isolated by membrane and chromatographic techniques and by crystallization.
Faculty of Environmental Technology

Chemical and biochemical transformations of phosphorus in wastewater treatment

Wanner Jiří, prof. Ing. DrSc. ( wan...@vscht.cz)
Srb Martin, Ing. Ph.D. ( mar...@pvk.cz)
The study will deal with chemical processes and emerging products in the precipitation of phosphates from wastewater in activated sludge. In the case of the use of precipitants based on iron III salts the influence of biological processes on the precipitation mechanism and the oxidation state of iron in precipitation products will be also studied. At the same time, the influence of low residual concentrations of phosphate phosphorus on the properties of activated sludge will be monitored both in terms of removal of selected components of pollution (eg nitrification) and microbial composition in terms of separation properties of activated sludge, formation of extracellular polymers or influence of formed precipitates on sedimentation ability. The next part of the work will focus on the possibilities of influencing the properties of activated sludge in case of increased biological phosphorus removal, competition of other components of biocenosis with poly-P bacteria and their influence on possible formation of biological foams or other separation problems.
Faculty of Chemical Engineering

Chemiresistors based on nanostructured oxides: detection of gaseous analytes with various characteristic groups

Vrňata Martin, prof. Ing. Dr. ( vrn...@vscht.cz)
Fitl Přemysl, Ing. Ph.D. ( f...@vscht.cz)
Although the first functional chemiresistors with oxidic sensitive layers were constructed in 1960's and since 1990's they are commercially produced in large series, their research and development is far from being completed. While the chemical composition of the sensitive layers has been more or less optimized, the boom of nanotechnologies in recent years brings new challenges how to improve chemiresistors by tuning morphology of their sensitive layers. The highest impact has the fact that the geometric dimensions of the oxidic nanostructures are comparable with Debye length of given material. Such circumstance enables us to approach the concept of "molecular switch", when just one molecule of the analyte switches on/off the conducting channel in the sensitive layer. This thesis will be focused on synthesis of oxidic nanostructures (preferably by hydrothermal methods) and on measurement of their response to certain "model analytes" (oxidizing gas, reducing gas, Lewis acid or base, variable molecular dipole-moment). The analytes will be selected according to such criteria, so that the obtained results can be generalized.
Faculty of Chemical Technology

Chemistry of inorganic analogues of graphene - nanostructures based on pnictogens

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
The thesis is focused on the covalent and non-covalent interactions of layered pnictogens in order to improve their long-term stability. Mono- and multi-layer materials will be prepared by optimized mechanical exfoliation processes. For non-covalent interactions, substituted delocalized organic systems will be tested and their effect on material transport properties will be studied. The covalent functionalization will be performed using radical reactions. Finally, preparation of functional microelectronic devices based on FET transistors and photodetectors will be studied and optimized.
Faculty of Chemical Technology

Chemistry of inorganic analogues of graphene - nanostructures based on pnictogens

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
The thesis is focused on the covalent and non-covalent interactions of layered pnictogens in order to improve their long-term stability. Mono- and multi-layer materials will be prepared by optimized mechanical exfoliation processes. For non-covalent interactions, substituted delocalized organic systems will be tested and their effect on material transport properties will be studied. The covalent functionalization will be performed using radical reactions. Finally, preparation of functional microelectronic devices based on FET transistors and photodetectors will be studied and optimized.
Faculty of Chemical Technology

Chiral Triptycene- or [2.2]Paracyclophane-Based Fluorination Reagents

Rybáčková Markéta, Ing. Ph.D. ( ryb...@vscht.cz)
Kvíčala Jaroslav, prof. Ing. CSc. ( kvi...@vscht.cz)
Iptycenes and cyclophanes have found applications as molecular machines, in polymer chemistry, materials chemistry or catalysis. Triptycene is characterized by an unusual D3h symmetry and its derivatives can be chiral. Similarly, [2.2]paracyclophane derivatives are intriguing due to their planar chirality. This work aims at incorporating chiral triptycenes or [2.2]paracyclophanes into fluorination reagents (imidazole derivatives or hypervalent silicon compounds). The prepared compounds will be used to study chemo-, regio- and stereoselectivity in nucleophilic fluorinations.
Faculty of Chemical Technology

Chiral Triptycene- or [2.2]Paracyclophane-Based Fluorination Reagents

Rybáčková Markéta, Ing. Ph.D. ( ryb...@vscht.cz)
Kvíčala Jaroslav, prof. Ing. CSc. ( kvi...@vscht.cz)
Iptycenes and cyclophanes have found applications as molecular machines, in polymer chemistry, materials chemistry or catalysis. Triptycene is characterized by an unusual D3h symmetry and its derivatives can be chiral. Similarly, [2.2]paracyclophane derivatives are intriguing due to their planar chirality. This work aims at incorporating chiral triptycenes or [2.2]paracyclophanes into fluorination reagents (imidazole derivatives or hypervalent silicon compounds). The prepared compounds will be used to study chemo-, regio- and stereoselectivity in nucleophilic fluorinations.
Faculty of Food and Biochemical Technology

Cutibacterium acnes: virulence factors and mobile genetic elements

Zdeňková Kamila, Ing. Ph.D. ( zde...@vscht.cz)
The gram-positive bacterium Cutibacterium acnes (formerly Propionibacterium acnes) is a skin commensal under physiological conditions, but it can also be an opportunistic pathogen causing invasive chronic infections. The most well-known diseases associated with C. acnes include Acne vulgaris; however, the connection with a number of other diseases is also clinically significant. The pathogenicity of C. acnes is due to a number of virulence factors, one of which is the formation of a biofilm, which increases the resistance of bacteria to antibiotics and other bactericidal substances, which negatively affects the effectiveness of treatment. C. acnes phylotype IA1, associated with acne, produce virulence factors as hemolysins, CAMP factors, neuraminidase, heat shock proteins (HSP) or lipase etc. Much of genes responsible for virulence and resistance is located on mobile genetic elements (MGEs). As part of the solution of this work, virulence factors will be studied using classical microbiological and modern molecular-biological methods.
Faculty of Food and Biochemical Technology

Identification of new psychoplastogenic compounds through structure-activity relationship studies as potential neurochemical tools for investigating human cognition

Kuchař Martin, doc. Ing. Ph.D. ( mar...@vscht.cz)
Objectives of this research project are to discover and synthetize novel chemical compounds with potential psychoplastogenic properties to be used as tools for neuroimaging studies elucidating their underlying neurobiological mechanisms.
Using structure-activity relationship investigations of already known and described psychoactive compounds primarily of the tryptamine and phenethylamine classes, this project aims to design and develop synthetic routes for their new analogues and to identify suitable substances for pharmacological and neurobiological investigations. Their biological activity will be tested within international collaboration for their interaction with monoamine receptors and transporters, cytotoxicity, and effects on growth of neuronal cells (by monitoring the BDNF factor). Selected compounds will be subjected to preclinical studies in animal models, especially with the use of behavioral tests and imaging methods such as EEG, fMRI and in the case of isotopically labeled substances also with PET.
Faculty of Food and Biochemical Technology

Impact of antibiotic resistance on the propagation of Gram-negative bacteria in the food chain

Purkrtová Sabina, Ing. Ph.D. ( pur...@vscht.cz)
The increasing incidence of antibiotic resistance in bacteria is one of the major problems of the 21st century, as it limits the range of suitable antibiotics for treating bacterial infections. The food chain is one of the places, where it happens the genesis of new antibiotics resistance determinants and/or their spreading (so-called hot spots). Selected groups of gram-negative bacteria (family Enterobacteriaceae, the genera Acinetobacter and Pseudomonas, etc.) form the very significant or the most numerous parts of bacteriome in many food products. At the same time, these bacterial groups are frequent carriers and spreaders of antibiotic resistance genes (e.g. by various mechanisms of horizontal gene transfer). However, the presence of antibiotic resistance genes, often linked to various mobile genetic elements, can not only bring benefits to their carriers, but in some cases can have a negative effect on their certain physiological and other properties (eg growth ability). Knowledge of the influence of the presence of antibiotic resistance genes on properties important for the spread of bacteria in the food chain (e.g. biofilm formation, growth ability, resistance to environmental stress conditions, etc.) is then important for determining the potential for their spread in the food chain and for developing methods to reduce it. The aim of the work will be to study and compare the isolates of the above groups of gram-negative bacteria isolated from food products with different antibiotic resistance profiles. The selection of important antibiotic resistance genes occurring in food isolates of the above groups of gram-negative bacteria will be performed. Furthermore, the occurrence of these antibiotic resistance genes in selected food products will be determined. It will be performed the isolation and quantification of target bacterial groups, genotypic and phenotypic characterization of the obtained isolates and comparison of the occurrence frequency of different genotypes and phenotypes. Modern methodological approaches such as next generation sequencing methods (e.g. nanopore sequencing), qPCR, MALDI-TOF MS and selected classical cultivation microbiological methods will be used for the study.
Faculty of Chemical Engineering

Influence of composite particle structure for targeted drug delivery

Tokárová Viola, Ing. Ph.D. ( vio...@vscht.cz)
The encapsulation of active substances in microscopic carriers finds its practical application in the food industry, cosmetics and pharmacy. The active substance is thus protected from the environment and can be delivered to the target site of action (eg: damaged tissue, tumour cells). The aim of this work is to prepare particles with diverse architecture and topography (eg: core-shell, particles with microtopography, fibrous structure) and to investigate the influence of particle architecture on release kinetics of encapsulated active ingredient. Methods of spray drying, encapsulation and microfluidics will be used for the preparation of composite particle systems in this work. The active ingredient will be selected with respect to the biomedical application.
Faculty of Chemical Engineering

Influence of composite particle structure for targeted drug delivery

Tokárová Viola, Ing. Ph.D. ( vio...@vscht.cz)
The encapsulation of active substances in microscopic carriers finds its practical application in the food industry, cosmetics and pharmacy. The active substance is thus protected from the environment and can be delivered to the target site of action (eg: damaged tissue, tumour cells). The aim of this work is to prepare particles with diverse architecture and topography (eg: core-shell, particles with microtopography, fibrous structure) and to investigate the influence of particle architecture on release kinetics of encapsulated active ingredient. Methods of spray drying, encapsulation and microfluidics will be used for the preparation of composite particle systems in this work. The active ingredient will be selected with respect to the biomedical application.
Faculty of Chemical Technology

Influence of Corrosion Products on Hydrogen Absorption to High Strength Steel

Prošek Tomáš, Ing. Ph.D. ( pro...@vscht.cz)
This project originates from industrial projects on hydrogen embrittlement (HE) of high strength steels, which are especially prone to hydrogen(H)-induced degradation. Since the development of these advanced steel grades with a huge potential of material and energy savings in many fields of human activity, the number of industry-funded studies on HE has been rising significantly. However, their practical focus does not allow for studying underlying mechanisms, although they are crucial for future development of products with improved application properties. This work aims at fundamental understanding of atmospheric corrosion as source for H insertion into iron, the principal element of all steel grades, as well as into selected steel grades. The role of corrosion products (CPs) in the H insertion during atmospheric corrosion will be clarified: How do composition and structure of CPs affect corrosion processes in view of H adsorption and absorption by e.g. reactions that involve a change of pH or a ratio between H reduction and other depolarization reactions? Which atmospheric conditions trigger these reactions? What is the mechanism of atomic H formation and entry?
Faculty of Chemical Technology

Influence of Corrosion Products on Hydrogen Absorption to High Strength Steel

Prošek Tomáš, Ing. Ph.D. ( pro...@vscht.cz)
This project originates from industrial projects on hydrogen embrittlement (HE) of high strength steels, which are especially prone to hydrogen(H)-induced degradation. Since the development of these advanced steel grades with a huge potential of material and energy savings in many fields of human activity, the number of industry-funded studies on HE has been rising significantly. However, their practical focus does not allow for studying underlying mechanisms, although they are crucial for future development of products with improved application properties. This work aims at fundamental understanding of atmospheric corrosion as source for H insertion into iron, the principal element of all steel grades, as well as into selected steel grades. The role of corrosion products (CPs) in the H insertion during atmospheric corrosion will be clarified: How do composition and structure of CPs affect corrosion processes in view of H adsorption and absorption by e.g. reactions that involve a change of pH or a ratio between H reduction and other depolarization reactions? Which atmospheric conditions trigger these reactions? What is the mechanism of atomic H formation and entry?
Faculty of Environmental Technology

Influence of hydrogen in natural gas on the gas infrastructure

Hlinčík Tomáš, doc. Ing. Ph.D. ( Tom...@vscht.cz)
Tenkrát Daniel, Ing. Ph.D. ( ten...@vscht.cz)
The thesis is focused on the study of different hydrogen content in natural gas and its influence on the gas infrastructure. At present, hydrogen is intended to be added to natural gas either as a pure gas or for example as a part of the gas produced by the catalytic hydrogenation of carbon dioxide. The issue of adding hydrogen to natural gas involves, in particular, mixing of hydrogen with natural gas in the pipeline system, influence on the calorific value and combustion properties, influence on the measuring and analytical systems, sealing systems, influence on natural gas compression at compressor stations, reduction of transport capacity, reduction of methane number or limiting factors during the storage of hydrogen - natural gas mixtures.
Faculty of Chemical Technology

Influence of radiolysis and bacterial extremophiles on lifetime of canister for radioactive waste repository

Stoulil Jan, doc. Ing. Ph.D. ( jan...@vscht.cz)
The work will be focused on the influence of bentonite pore solution radiolysis by gamma radiation on the oxidation ability, stability and semiconductive properties of passive layer on the 316L stainless steel. In addition will be studied the possibility of the formation of sulphate-reducing bacteria biofilm and the effect of metabolites on the susceptibility to pitting and stress corrosion cracking.
Faculty of Environmental Technology

Innovation for the Environmental and Economic Sustainability of Mobility

Kočí Vladimír, doc. Ing. Ph.D., MBA ( k...@vscht.cz)
Švecová Lenka, doc. Ing. Ph.D. ( sve...@vscht.cz)
Environmental investment projects are often perceived as regulatory investments and as such are assessed by methods that do not take into account economic efficiency, although this should be the case - regardless of the value of the output. The dissertation analyzes the currently used methods, defines their shortcomings in the use of various types of investment projects and based on systematization and quantitative research proposes methods adapted to individual types of investments that will identify specific aspects that affect the evaluated project and include them in project evaluation.
Development principles: Analyzujte v současnosti používané metody, vymezte jejich nedostatky při používání pro různé typy používaných investičních projektů a na základě systematizace a kvantitativního výzkumu navrhněte metody upravené pro jednotlivé typy investic, které budou identifikovat specifické aspekty, které hodnocený projekt ovlivňují a začlení je do hodnocení projektů.
Metodologie: analýza sekundárních pramenů, metody primárního výzkumu: dotazníkový průzkum, polostrukturované a nestrukturované rozhovory, modelování, testování, návrh normativního modelu
Faculty of Food and Biochemical Technology

Innovation of foods based on lactic acid fermented vegetables and fruits

Rajchl Aleš, doc. Ing. Ph.D. ( ale...@vscht.cz)
Horsáková Iveta, Ing. Ph.D. ( ive...@vscht.cz)
Lactic acid fermented foods are known for centuries. Thanks to its long sustainability, increased nutritional value, required sensory properties and also unpretentious and cheap preparation have become very popular worldwide. This work is focused on the preparation of lactic acid fermented vegetable and fruit products and on the possibilities to enlarge the range of these products. Specifically, a fermentability of individual types of vegetables or fruits, including its mixtures, will be determined with respect to sensory properties of the final products. The effect of addition of probiotic and starter cultures will be estimated according to selected qualitative properties of the products. During fermentation processes characteristic changes will be monitored through the chemical, microbiological and sensory parameters.
Faculty of Food and Biochemical Technology

Innovative strategies for food fraud detection

Hajšlová Jana, prof. Ing. CSc. ( haj...@vscht.cz)
Hůrková Kamila, Ing. Ph.D. ( HUR...@vscht.cz)
The doctoral thesis realized within the international project will focus on the use of modern instrumental methods, especially high-resolution mass spectrometry, for the analysis of food raw materials, foods and food supplements. To recognize a fraud / verify authenticity of investigated samples, a strategy of comparing measured ‘fingerprints´ and profiles of selected biomarkers with records in a database constructed on the basis of fully characterized, authentic samples, will be employed. Advanced multi-dimensional chemometric strategies will be used for data processing. The project will also assess the potential health risks to consumers related to fraud.
Faculty of Food and Biochemical Technology

Innovative strategies for food fraud detection

Hajšlová Jana, prof. Ing. CSc. ( haj...@vscht.cz)
Hůrková Kamila, Ing. Ph.D. ( HUR...@vscht.cz)
The doctoral thesis realized within the international project will focus on the use of modern instrumental methods, especially high-resolution mass spectrometry, for the analysis of food raw materials, foods and food supplements. To recognize a fraud / verify authenticity of investigated samples, a strategy of comparing measured ‘fingerprints´ and profiles of selected biomarkers with records in a database constructed on the basis of fully characterized, authentic samples, will be employed. Advanced multi-dimensional chemometric strategies will be used for data processing. The project will also assess the potential health risks to consumers related to fraud.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Technology

Inorganic carriers of active pharmaceutical ingredients

Kovanda František, prof. Ing. CSc. ( kov...@vscht.cz)
The work is focused on development of new solid dosage forms. Release of active pharmaceutical ingredient and its stability against degradation can be considerably affected after its incorporation into a carrier. Inorganic compounds with layered structure, namely the layered double hydroxides suitable for intercalation of negatively charged anionic species, will be used as the host structures. Methods for preparation of intercalates, interactions between the host structure and drugs intercalated in interlayer, stability of intercalated drugs, and their back release in simulated body fluids will be studied.
Faculty of Chemical Technology

Inorganic carriers of active pharmaceutical ingredients

Kovanda František, prof. Ing. CSc. ( kov...@vscht.cz)
The work is focused on development of new solid dosage forms. Release of active pharmaceutical ingredient and its stability against degradation can be considerably affected after its incorporation into a carrier. Inorganic compounds with layered structure, namely the layered double hydroxides suitable for intercalation of negatively charged anionic species, will be used as the host structures. Methods for preparation of intercalates, interactions between the host structure and drugs intercalated in interlayer, stability of intercalated drugs, and their back release in simulated body fluids will be studied.

Study Programme:

Faculty of Chemical Technology

Inorganic graphene analogs - sillicone, germicen and derivatives of them

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
Topic is focus on development o novel inorganic analogues of graphene, study of their reactivity and possibilities of derivatisation. Synthetic methods will focus on development of Zintl phase exfoliation procedures. Materials will be studied for future applications in photocatalysis and electrocatalysis as well as energy storage applications.
Faculty of Environmental Technology

Integration of Risk and Uncertainty into Investment Decisions in Selected Industrial Sectors in Relation to Environmental Protection

Kočí Vladimír, doc. Ing. Ph.D., MBA ( k...@vscht.cz)
Švecová Lenka, doc. Ing. Ph.D. ( sve...@vscht.cz)
The dissertation thesis is focused on the integration of risk and uncertainty into investment decisions in selected sectors of industry in relation to environmental protection. Given the long-term investment, attention must be paid to the long-term effects; the scenario approach is necessary while respecting the specificities of the sector (industry). The aim is to create a normative model that respects scenario approaches, uncertainty in the environment, multi-criteria decision-making processes and sector specificities.
Development principles: Identifikujte klíčové rizikové faktory ovlivňující rozhodovací procesy o investicích. Při identifikaci je nezbytné respektovat specifika odvětví. Při hodnocení investic z pohledu integrace rizika a nejistoty respektujte multikriteriální přístup s respektování faktorů týkajících se ochrany životního prostředí.
Metodologie: analýza sekundárních pramenů z Web of Science a Scopus, metody primárního výzkumu: dotazníkový průzkum, polostrukturované a nestrukturované rozhovory, testování, návrh normativního modelu
Faculty of Chemical Technology

Intelligent materials and surfaces - switching between "ultra" states

Lyutakov Oleksiy, Mgr. Ph.D. ( ole...@vscht.cz)
Faculty of Chemical Technology

Interaction of glass containing biogenic components with aqueous solutions

Helebrant Aleš, prof. Ing. CSc. ( hel...@vscht.cz)
In addition to the traditional use of glass as containers or in the building and automotive industries, some glass can be used in medicine, pharmacy or agriculture. The aim of the thesis will be to explore and describe the kinetics of interaction of appropriately selected or prepared soluble phosphorous and phosphosilicate and glass with other biogenic components) with aqueous solutions simulating soil or body environment and to design glass that can be used as slowly soluble fertilizers or bioresorbable materials in medicine.
Faculty of Environmental Technology

Interaction of structural materials with supercritical water

Macák Jan, doc. Ing. CSc. ( mac...@vscht.cz)
The use of supercritical water as working fluid of power cycles is motivated by the need to increase thermal efficiency.
The structural materials are exposed to very severe corrosion conditions in supercritical water. The aim of the work is to prove corrosion behaviour of selected structural materials in supercritical water. Part of the work will be oriented towards the application of novelty methods of surface treatment and development and performance of in-situ tests of corrosion characteristics at slightly subcritical, critical and supercritical conditions.
Faculty of Environmental Technology

Investigation of Cu-based catalyst in hydrogenolysis of esters

Kubička David, doc. Ing. Ph.D., MBA ( Dav...@vscht.cz)
Hydrogenolysis catalysts are an important class of catalysts that need to be innovated to replace the traditional chromium-containing catalysts. The work will be focused on the synthesis and detailed characterization of Cu-based catalyst including the use of in-situ characterization. The synthesis and characterization data will be combined with the catalytic results of ester hydrogenolysis both in the liquid and gas phases. This will allow elucidating the effects of the local Cu environment on the catalyst activity, selectivity, and stability and provide further insights into the similarities and differences of gas and liquid phase processes.
Faculty of Food and Biochemical Technology

Investigation of the stability and changes of food products using direct spectral methods

Poustka Jan, prof. Dr. Ing. ( pou...@vscht.cz)
The dissertation is focused on the application of selected direct spectral methods such as infrared spectrometry (ATR-FTIR) or mass spectrometry (DART-MS) in order to investigate the stability and changes of food products during storage and conventional culinary treatments. The aim of this work is to develop analytical procedures suitable for their characterization for various materials with a focus on key components such as lipids or carbohydrates so that they can be used to authenticate or differentiate them according to the origin or degree of technological processing.In addition to the applied analytical methods, advanced statistical methods, including multivariate data analysis, will be used for data processing, which allows sorting into characteristic groups.
Faculty of Chemical Technology

Investigation of water electrolysis with proton exchange membrane

Bystroň Tomáš, doc. Ing. Ph.D. ( bys...@vscht.cz)
Water electrolysis represents an important part of the hydrogen economy considered nowadays as a promising approach to the future securing of the human society with electrical energy. Industrial water electrolysis processes established today suffer from several disadvantages when considering its application in the field of energetics. It is mainly its low efficiency and flexibility. Therefore, this process is a subject of interest of numerous research laboratories around the globe. Electrode reaction kinetics, suitable polymer electrolytes and overall process design represent the main issues studied. Corrosion stability of the individual construction materials is also an issue.
Faculty of Chemical Technology

Investigation of water electrolysis with proton exchange membrane

Bystroň Tomáš, doc. Ing. Ph.D. ( bys...@vscht.cz)
Water electrolysis represents an important part of the hydrogen economy considered nowadays as a promising approach to the future securing of the human society with electrical energy. Industrial water electrolysis processes established today suffer from several disadvantages when considering its application in the field of energetics. It is mainly its low efficiency and flexibility. Therefore, this process is a subject of interest of numerous research laboratories around the globe. Electrode reaction kinetics, suitable polymer electrolytes and overall process design represent the main issues studied. Corrosion stability of the individual construction materials is also an issue.
Faculty of Food and Biochemical Technology

Isolation of novel therapeutics form fungi

Kotrba Pavel, prof. Ing. Ph.D. ( kot...@vscht.cz)
Kuchař Martin, doc. Ing. Ph.D. ( mar...@vscht.cz)
Fungi have been always on the forefront of biotechnological research, be it for antibiotics, food production, various enzymatic mixtures etc. Yet, there is still an untapped potential with regards to therapeutic use against cancer or various psychological disorders, although there are reports of fungi being traditionally used for such purposes. This dissertation project is aimed on the identification and isolation of novel therapeutics from common forest fungi such as Amanita muscaria and testing of the therapeutic potential of the isolated substances in various types of cancer cell lines.
Faculty of Chemical Technology

Kinetics of catalytic decomposition of N2O on zeolite catalysts

Fíla Vlastimil, doc. Dr. Ing. ( f...@vscht.cz)
Bernauer Milan, Ing. Ph.D. ( ber...@vscht.cz)
The topic of this work is the study of kinetics of N2O decomposition on zeolitic (MFI, FER) and titano-silicates catalysts involving Fe and other transition metals. The work will be focused on kinetic experiments in aiming to develop reliable kinetic model suitable for desing of industrial equipment.
Faculty of Chemical Technology

Kinetics of catalytic decomposition of N2O on zeolite catalysts

Fíla Vlastimil, doc. Dr. Ing. ( f...@vscht.cz)
Bernauer Milan, Ing. Ph.D. ( ber...@vscht.cz)
The topic of this work is the study of kinetics of N2O decomposition on zeolitic (MFI, FER) and titano-silicates catalysts involving Fe and other transition metals. The work will be focused on kinetic experiments in aiming to develop reliable kinetic model suitable for desing of industrial equipment.
Faculty of Chemical Engineering

KLa - shear stress coupling to design fermenters better

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
In fermentation technologies, mechanically agitated aerated vessels are frequently used. In cases of aerobic fermentations, the Oxygen Uptake Rate - OUR is frequently used as the important design parameter. This means that the gas-liquid mass transfer controlled process is considered and the volumetric mass transfer coefficient - kLa is taken as the most important parameter. The practice shows, however, that the impellers with lower Power number (which means lower turbulence intensity and lower kLa) often ensure higher bioprocess efficiency than those with high Power number (which means higher turbulence intensity and higher kLa). The explanation is brought by the fact that microorganisms/biomass might be damaged by the high turbulence intensity as explained further. The turbulence intensity is proportional to shear stresses occuring in the mechanically agitated fermentation batch. A high shear stress may "cut" the microorganisms, which stop producing their primary product then. The aim of the PhD thesis is to measure the quantities proportional to shear stress values at the process conditions of aerobic fermentations and couple them with the kLa values, which are already at disposal in the Mass Transfer Lab database at UCT Prague. This data coupling will enable to develope the highly efficient industrial fermenters design tool.
Development principles: 1. Seznamte se s popisem transportu hmoty mezi plynem a kapalinou v mechanicky míchaných disperzích
2. Seznamte se s popisem lokálních intenzit turbulnce, fluktuačních rychostí a střižných sil v mechanicky míchaných disperzích kapalina-plyn
3. Prostudujte experimentální techniky měření kLa v Laboratoři sdílení hmoty VŠCHT Praha a techniky měření veličin úměrných intenzitě turbulence na TU Berlin.
4. Prostudujte experimetální podmínky použité k získání kLa dat v databázi na VŠCHT Praha a za shodných podmínek proměřte veličiny úměrné intenzitě turbulence metodikami užívanými na TU Berlin
5. Doplňte databázi kLa dat o veličiny použitelné k výpočtu střižných rychlostí a navrhněte způsob využití takto spárovaných veličin pro návrh mechanicky míchaných fermentorů.
Faculty of Chemical Engineering

KLa - shear stress coupling to design fermenters better

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
In fermentation technologies, mechanically agitated aerated vessels are frequently used. In cases of aerobic fermentations, the Oxygen Uptake Rate - OUR is frequently used as the important design parameter. This means that the gas-liquid mass transfer controlled process is considered and the volumetric mass transfer coefficient - kLa is taken as the most important parameter. The practice shows, however, that the impellers with lower Power number (which means lower turbulence intensity and lower kLa) often ensure higher bioprocess efficiency than those with high Power number (which means higher turbulence intensity and higher kLa). The explanation is brought by the fact that microorganisms/biomass might be damaged by the high turbulence intensity as explained further. The turbulence intensity is proportional to shear stresses occuring in the mechanically agitated fermentation batch. A high shear stress may "cut" the microorganisms, which stop producing their primary product then. The aim of the PhD thesis is to measure the quantities proportional to shear stress values at the process conditions of aerobic fermentations and couple them with the kLa values, which are already at disposal in the Mass Transfer Lab database at UCT Prague. This data coupling will enable to develope the highly efficient industrial fermenters design tool.
Development principles: 1. Seznamte se s popisem transportu hmoty mezi plynem a kapalinou v mechanicky míchaných disperzích
2. Seznamte se s popisem lokálních intenzit turbulnce, fluktuačních rychostí a střižných sil v mechanicky míchaných disperzích kapalina-plyn
3. Prostudujte experimentální techniky měření kLa v Laboratoři sdílení hmoty VŠCHT Praha a techniky měření veličin úměrných intenzitě turbulence na TU Berlin.
4. Prostudujte experimetální podmínky použité k získání kLa dat v databázi na VŠCHT Praha a za shodných podmínek proměřte veličiny úměrné intenzitě turbulence metodikami užívanými na TU Berlin
5. Doplňte databázi kLa dat o veličiny použitelné k výpočtu střižných rychlostí a navrhněte způsob využití takto spárovaných veličin pro návrh mechanicky míchaných fermentorů.

Chemical and Process Engineering

Study Programme:

Faculty of Chemical Engineering

KLa - shear stress coupling to design fermenters better

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
In fermentation technologies, mechanically agitated aerated vessels are frequently used. In cases of aerobic fermentations, the Oxygen Uptake Rate - OUR is frequently used as the important design parameter. This means that the gas-liquid mass transfer controlled process is considered and the volumetric mass transfer coefficient - kLa is taken as the most important parameter. The practice shows, however, that the impellers with lower Power number (which means lower turbulence intensity and lower kLa) often ensure higher bioprocess efficiency than those with high Power number (which means higher turbulence intensity and higher kLa). The explanation is brought by the fact that microorganisms/biomass might be damaged by the high turbulence intensity as explained further. The turbulence intensity is proportional to shear stresses occuring in the mechanically agitated fermentation batch. A high shear stress may "cut" the microorganisms, which stop producing their primary product then. The aim of the PhD thesis is to measure the quantities proportional to shear stress values at the process conditions of aerobic fermentations and couple them with the kLa values, which are already at disposal in the Mass Transfer Lab database at UCT Prague. This data coupling will enable to develope the highly efficient industrial fermenters design tool.
Development principles: 1. Get familiar with the description of the gas-liquid mass transfer in mechanically agitated dispersions.
2. Get familiar with the descritpion of local turbulence intensities., fluctuation velocities and shear stresses in mechanically agitated gas-liquid disperions.
3. Study experimental techniques of kLa measurement in UCT Mass transfer Laboratory and of the quantities proportional to the local turbulence intensity used at TU Berlin.
4. Study the eperimental conditions used in Mass Transfer Laboratory at UCT Prague to obtain kLa database and then, at the same conditions measure the quantities proportional to local turbulence intensities as used at TU Berlin.
5. Complete the kLa database by the quantities usable to compute shear stresses and suggest the way how to use these coupled data in industrial fermenters design.
Faculty of Chemical Engineering

KLa - shear stress coupling to design fermenters better

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
In fermentation technologies, mechanically agitated aerated vessels are frequently used. In cases of aerobic fermentations, the Oxygen Uptake Rate - OUR is frequently used as the important design parameter. This means that the gas-liquid mass transfer controlled process is considered and the volumetric mass transfer coefficient - kLa is taken as the most important parameter. The practice shows, however, that the impellers with lower Power number (which means lower turbulence intensity and lower kLa) often ensure higher bioprocess efficiency than those with high Power number (which means higher turbulence intensity and higher kLa). The explanation is brought by the fact that microorganisms/biomass might be damaged by the high turbulence intensity as explained further. The turbulence intensity is proportional to shear stresses occuring in the mechanically agitated fermentation batch. A high shear stress may "cut" the microorganisms, which stop producing their primary product then. The aim of the PhD thesis is to measure the quantities proportional to shear stress values at the process conditions of aerobic fermentations and couple them with the kLa values, which are already at disposal in the Mass Transfer Lab database at UCT Prague. This data coupling will enable to develope the highly efficient industrial fermenters design tool.
Development principles: 1. Seznamte se s popisem transportu hmoty mezi plynem a kapalinou v mechanicky míchaných disperzích
2. Seznamte se s popisem lokálních intenzit turbulnce, fluktuačních rychostí a střižných sil v mechanicky míchaných disperzích kapalina-plyn
3. Prostudujte experimentální techniky měření kLa v Laboratoři sdílení hmoty VŠCHT Praha a techniky měření veličin úměrných intenzitě turbulence na TU Berlin.
4. Prostudujte experimetální podmínky použité k získání kLa dat v databázi na VŠCHT Praha a za shodných podmínek proměřte veličiny úměrné intenzitě turbulence metodikami užívanými na TU Berlin
5. Doplňte databázi kLa dat o veličiny použitelné k výpočtu střižných rychlostí a navrhněte způsob využití takto spárovaných veličin pro návrh mechanicky míchaných fermentorů.

Study Programme:

Faculty of Chemical Technology

Large deformations of ceramic powder compacts and fracture of porous and cellular ceramics

Pabst Willi, prof. Dr. Dipl. Min. ( pab...@vscht.cz)
Uhlířová Tereza, Ing. Ph.D. ( ter...@vscht.cz)
Large deformations play a significant role in ceramic technology, because all pressing operations rely on the quasi-plastic behavior of powder systems during consolidation. On the other hand, also porous and cellular ceramics, including those produced via additive manufacturing, e.g. 3D printing, exhibit quasi-plastic behavior during compression. This PhD topic combines theory-based analytical modeling and computer-based numerical modeling of large deformations with real-world experiments performed on ceramic materials via different mechanical tests, mainly axial and diametral compression. The student is required to have a solid background knowledge in ceramic science and technology as well as the ability to combine computer modeling with experimental work on real materials from both fine and coarse ceramics.
Faculty of Chemical Technology

Large deformations of ceramic powder compacts and fracture of porous and cellular ceramics

Pabst Willi, prof. Dr. Dipl. Min. ( pab...@vscht.cz)
Uhlířová Tereza, Ing. Ph.D. ( ter...@vscht.cz)
Large deformations play a significant role in ceramic technology, because all pressing operations rely on the quasi-plastic behavior of powder systems during consolidation. On the other hand, also porous and cellular ceramics, including those produced via additive manufacturing, e.g. 3D printing, exhibit quasi-plastic behavior during compression. This PhD topic combines theory-based analytical modeling and computer-based numerical modeling of large deformations with real-world experiments performed on ceramic materials via different mechanical tests, mainly axial and diametral compression. The student is required to have a solid background knowledge in ceramic science and technology as well as the ability to combine computer modeling with experimental work on real materials from both fine and coarse ceramics.
Faculty of Chemical Technology

Layered carbides – novel materials for electronic applications

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
Topic is focused on synthesis of layered carbides (MAX phases) and their exfoliation on MXene. Synthesis and exfoliation procedures will be optimized to reach maximum yield of monolayers. Synthesized materials will be characterized by structural and spectroscopic analytical methods. Materials will be studied for applications in energy storage filed including batteries and supercapacitors.
Faculty of Chemical Technology

Layered double hydroxides as sorbents for biologically active substances

Paterová Iva, Ing. Ph.D. ( iva...@vscht.cz)
Double layered hydroxides, also known as hydrotalcite or anionic clays, are an important group of materials with a wide range of applications. They can be applied as catalysts, catalyst precursors or ion exchangers, in sorption and decontamination processes. They can also be used for the intercalation of various substances including drugs. The aim of this work will be to prepare these materials, modify their surface with silanol based compounds and to characterize them by suitable methods. The prepared materials will be used as support materials for the immobilization of selected active substances.
Faculty of Chemical Technology

Layered double hydroxides as sorbents for biologically active substances

Paterová Iva, Ing. Ph.D. ( iva...@vscht.cz)
Double layered hydroxides, also known as hydrotalcite or anionic clays, are an important group of materials with a wide range of applications. They can be applied as catalysts, catalyst precursors or ion exchangers, in sorption and decontamination processes. They can also be used for the intercalation of various substances including drugs. The aim of this work will be to prepare these materials, modify their surface with silanol based compounds and to characterize them by suitable methods. The prepared materials will be used as support materials for the immobilization of selected active substances.
Faculty of Chemical Technology

Layered forms of silicon and germanium and their optical properties and applications

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
The fast-growing family of layered materials based on silicon and germanium possess unique optical properties which are strongly dependent on their surface functionalization. This work will be focused on chemical modifications of the surface of silicon and germanium layers and the influence of introduced functional groups on their luminescent properties. The optimized materials will be tested for electronic applications with a focus on hybrid LEDs and solar cells. Further, student will investigate a compatibility of synthesized 2D nanomaterials with organic semiconductors for a preparation of the hybrid optoelectronic heterostructures.
Faculty of Chemical Technology

Layered forms of silicon and germanium and their optical properties and applications

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
The fast-growing family of layered materials based on silicon and germanium possess unique optical properties which are strongly dependent on their surface functionalization. This work will be focused on chemical modifications of the surface of silicon and germanium layers and the influence of introduced functional groups on their luminescent properties. The optimized materials will be tested for electronic applications with a focus on hybrid LEDs and solar cells. Further, student will investigate a compatibility of synthesized 2D nanomaterials with organic semiconductors for a preparation of the hybrid optoelectronic heterostructures.
Faculty of Chemical Technology

Layered chalcogenides for energy storage applications

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
This thesis is focused on the exploration of layered chalcogenides and their applications in energy storage and electrocatalysis.
Faculty of Chemical Technology

Layered chalcogenides for energy storage applications

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
This thesis is focused on the exploration of layered chalcogenides and their applications in energy storage and electrocatalysis.
Faculty of Environmental Technology

Life cycle assessment of logistics

Kočí Vladimír, doc. Ing. Ph.D., MBA ( k...@vscht.cz)
The environmental aspects of logistics should be one of the criteria taken into account by project planners. The LCA method makes it possible to compare the environmental impacts of different anthropogenic stressors with respect to the entire life cycle of the product, technology or service. Environmental impacts can be assessed globally or locally, but mainly either in general or with a focus on the site. This work will focus on the creation of a methodology for the identification and presentation of environmental aspects of logistics.
Development principles: Na základě konzultací se školitelem a konzultanty z praxe vypracujte metodiku určování environmentálních dat logistiky.
Faculty of Chemical Engineering

Liquid-gas ejector as compact and economic reactor

Haidl Jan, Ing. Ph.D. ( jan...@vscht.cz)
Faculty of Chemical Engineering

Liquid-gas ejector as compact and economic reactor

Haidl Jan, Ing. Ph.D. ( jan...@vscht.cz)
Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
Faculty of Chemical Engineering

Machine Learning in Computational Spectroscopy

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
Artificial intelligence and machine learning approaches have recently witnessed a massive development in various fields of science and technology. In the suggested thesis, the candidate will apply these techniques into the field of computational spectrsocopy with a focus on electronic spectroscopies. For more information, see http://photox.vscht.cz
Faculty of Food and Biochemical Technology

Manifestations of synergy and antagonism in multispecies biofilms

Masák Jan, prof. Ing. CSc. ( mas...@vscht.cz)
Maťátková Olga, doc. Ing. Ph.D. ( olg...@vscht.cz)
Biofilm formation and other virulence factors are subject to different regulatory mechanisms which, depending on the particular microorganism, use different types of chemical compounds as regulatory signales. In multispecies biofilms, a complex system of these molecules is created. They can enter into interactions with each other or with the microorganisms present and significantly influence the mentioned regulatory mechanisms, which then result in very different relationships throughout the microbial community. The subject of the proposed dissertation topic is the targeted formation of multispecies communities and understanding of their physiology and other properties during the formation and stabilization of biofilm.
Faculty of Environmental Technology

Material and energetic use of plastic waste

Pohořelý Michael, doc. Ing. Ph.D. ( poh...@icpf.cas.cz)
Faculty of Environmental Technology

Material degradation in flue gas and CO2 environment at high temperature

Hlinčík Tomáš, doc. Ing. Ph.D. ( Tom...@vscht.cz)
Berka Jan, Ing. Ph.D. ( jan...@vscht.cz)
Development principles: - ve vhodných zdrojích vyhledejte údaje o degradaci, korozi a změnách vlastností vybraných kovových materiálů ve spalinách, prostředí CO2 a dalších podobných plynných prostředích - Orientační přehled materiálů: P91, 316, 316 L, Alloy 800H, Inconel 617, Inconel 713, Inconel 738 - další materiály dle upřesnění vedoucího práce a konzultantů - získané znalosti aplikujte na zhodnocení výsledků dosud uskutečněných testů materiálů na Ú216 VŠCHT v rámci projektu NF - závěry, výstupy a doporučení formulujte v písemné práci (zprávě k projektu)
Faculty of Chemical Engineering

Mathematical modeling of microfluidic devices for separation of racemic

Přibyl Michal, prof. Ing. Ph.D. ( pri...@vscht.cz)
Microfluidic devices are characterized by a large ratio of interfacial area to internal volume. This can be used in chemical separations by extraction or membrane processes. Separation of optically active substances, often important pharmaceutical or food products, at membranes or sorbents with anchored chiral selectors represents a great challenge for chemical engineers. Mathematical modeling can lead to a better understanding of complex processes in such devices and consequently to the design of efficient microfluidic separators.
The main objectives of the PhD project are:
Based on preliminary and available experimental data, a mathematical-physical description of mass and momentum transport in microfluidic devices with anchored chiral selectors will be developed.
Mathematical models of processes on different spatial scales will be created. They will include description of transport of the separated chemicals by diffusion, convection and electromigration.
Models will be analyzed numerically. Parameter values that ensure high separation efficiency and high productivity of the microfluidic system will be searched in the parameter space.
The lab is equipped with modern computers. The participation of the doctoral student in grant projects and active participation in international scientific conferences is expected.
Faculty of Chemical Engineering

Mathematical modeling of microfluidic devices for separation of racemic mixtures

Přibyl Michal, prof. Ing. Ph.D. ( pri...@vscht.cz)
Microfluidic devices are characterized by a large ratio of interfacial area to internal volume. This can be used in chemical separations by extraction or membrane processes. Separation of optically active substances, often important pharmaceutical or food products, at membranes or sorbents with anchored chiral selectors represents a great challenge for chemical engineers. Mathematical modeling can lead to a better understanding of complex processes in such devices and consequently to the design of efficient microfluidic separators. The main objectives of the PhD project are: Based on preliminary and available experimental data, a mathematical-physical description of mass and momentum transport in microfluidic devices with anchored chiral selectors will be developed. Mathematical models of processes on different spatial scales will be created. They will include description of transport of the separated chemicals by diffusion, convection and electromigration. Models will be analyzed numerically. Parameter values that ensure high separation efficiency and high productivity of the microfluidic system will be searched in the parameter space. The lab is equipped with modern computers. The participation of the doctoral student in grant projects and active participation in international scientific conferences is expected.
Faculty of Chemical Technology

Mathematical modelling of chemical and membrane processes using universal simulation programs

Fíla Vlastimil, doc. Dr. Ing. ( f...@vscht.cz)
Universal simulation programs introduce a tool suitable for design of new and optimization of existing industrial technologies. In the frame of this work the static and dynamic models of selected advanced membrane and/or chemical technologies or their parts will be developed using universal simulation programs. By the help of them and computer experiment the behavior of these technologies will be studied. Verification of developed models by experimental data will be implemented. Aim of the work is the improvement of economic and ecological technological parameters. The universal simulation programs from Aspen Technology will be used preferentially.
Faculty of Chemical Technology

Mathematical modelling of chemical and membrane processes using universal simulation programs

Fíla Vlastimil, doc. Dr. Ing. ( f...@vscht.cz)
Universal simulation programs introduce a tool suitable for design of new and optimization of existing industrial technologies. In the frame of this work the static and dynamic models of selected advanced membrane and/or chemical technologies or their parts will be developed using universal simulation programs. By the help of them and computer experiment the behavior of these technologies will be studied. Verification of developed models by experimental data will be implemented. Aim of the work is the improvement of economic and ecological technological parameters. The universal simulation programs from Aspen Technology will be used preferentially.
Faculty of Chemical Technology

Mathematical models of composite materials prepared by dispersing solid particles of a filler in a liquid polymer matrix

Čapek Pavel, doc. Ing. CSc. ( cap...@vscht.cz)
The work is aimed at the mathematical modelling of composite materials, the preparation of which includes the creation of a suspension of solid particles in a liquid mixture of a solvent and a polymer precursor, volume contraction of the suspension caused by evaporating the solvent and by forming a solid polymer matrix. The initial suspension is modelled using the random sequential addition of particles of various shapes. Then, the motion of particles of the filler in the shrinking suspension is simulated. Each model microstructure and the corresponding microstructure of the real composite material sample are characterised using statistical measures and these measures are subsequently compared with each other for the quality of the model to be evaluated. The real microstructures are deduced from digital images of their polished sections that are observed using a scanning electron microscope.
Faculty of Environmental Technology

Meat and bone meal as a source of valuable elements

Pohořelý Michael, doc. Ing. Ph.D. ( poh...@icpf.cas.cz)
Faculty of Chemical Technology

Mechanism of atmospheric low-temperature stress corrosion cracking of stainless steel

Prošek Tomáš, Ing. Ph.D. ( pro...@vscht.cz)
Stainless steels provide excellent service when selected and applied properly. Sufficient knowledge base is generally available for material selection for immersion conditions. This is not true for applications of stainless steels under atmospheric weathering conditions. Several cases of ceiling collapse and other component failures have shown that austenitic stainless steels are prone to stress corrosion cracking (SCC) under specific atmospheric conditions characterized by the spontaneous formation of concentrated chloride solutions under highly soluble chloride deposits even at room or only slightly elevated temperatures. This was observed in indoor swimming pools, for outdoor climbing anchors and under evaporative conditions in oil and gas production, storage, and processing. In collaboration with UCT Prague, the Safety Commission of Union Internationale des Associations d'Alpinisme (UIAA) introduced a new standard, which classifies climbing anchors into classes according to their resistance to SCC and/or corrosion. In the next step, particular environments will be classified. However, this requires deeper understanding into the degradation mechanism of stainless steels under relevant conditions is necessary. Factors influencing the SCC initiation and propagation such as the composition and concentration of deposits, tensile stress, role of crevices and aggressive ion accumulation, rock chemistry, periodic washing, stainless steel composition and microstructure and others will be systematically studied. In particular, in situ experiments will be carried out using X-ray micro tomography (μ-CT), which will allow for real time monitoring of crack initiation and propagation. In addition, outdoor exposures of numerous stainless steel grades and alternative materials organised around the world by UIAA will be followed and supported by failure analyses and specific measurements and tests.
Faculty of Chemical Technology

Mechanism of the formation of intermetallics in mechanical alloying

Novák Pavel, doc. Ing. Ph.D. ( pan...@vscht.cz)
Mechanical alloying is a popular technology for the preparation of powders of alloys or intermediary compounds (e.g. intermetallics, carbides or borides) by high energy mechanical milling. The high popularity of the method is given by the fact that it usually leads to nanostructured materials and that even non-miscible elements can create solid solutions during mechanical alloying. Even though the result is known and there are many descriptions available, the mechanism of the formation of intermetallics in this process is not fully understood yet. The reasons are probably in a large variety of possible process parameters and by impossibility to measure the temperature inside the powder in the milling jar. This work proposes following concept: indirect determination of the dependence of the peak powder temperature on milling conditions (rpm, ball-to-powder ratio, ball size) by the use of thermally decomposing salts, comparison of phase composition of the mechanically alloyed powder with the reference powder mixture exposed in the furnace to the detected peak temperature and observation of the time development of the microstructure and phase composition by XRD and electron microscopy (SEM, TEM). The mechanism will be observed on several different systems containing brittle and ductile powders (e.g. Ti-Al, Ti-Si, Ti-Al-Si) and the general conclusion regarding the mechanical alloying mechanism will be formulated.
Faculty of Food and Biochemical Technology

Mechanisms of bacterial antibiotic resistance and their modulation

Viktorová Jitka, Ing. Ph.D. ( pro...@vscht.cz)
Faculty of Chemical Technology

Mechanochemical indicators for optical spectroscopy

Krupička Martin, Ing. Ph.D. ( mkz...@gmail.com)
Mechanochemical indicators change its spectroscopic properties as a function of applied mechanical force. The goal of the thesis is to synthesize and study such indicators. Suitable molecules will be proposed, based on known chromophores and mechanophores and studied using quantum chemical methods. Selected molecules will be synthesized and studied with spectroscopic techniques with and without presence of mechanical force. Molecules allowing for measuring and quantification of mechanical force should be result of this work, together with theoretical model of its action.
Faculty of Chemical Technology

Melting processes in vitrification technologies

Kloužek Jaroslav, doc. Ing. CSc. ( klo...@vscht.cz)
The analysis of the processes during the vitrification process is performed using a mathematical model. Input data of the model will be obtained by a set of experimental methods including high temperature monitoring of melting processes, analysis of released gases, thermal analysis and determination of oxidative reduction equilibrium in melts.
Faculty of Chemical Technology

Melting processes in vitrification technologies

Kloužek Jaroslav, doc. Ing. CSc. ( klo...@vscht.cz)
The analysis of the processes during the vitrification process is performed using a mathematical model. Input data of the model will be obtained by a set of experimental methods including high temperature monitoring of melting processes, analysis of released gases, thermal analysis and determination of oxidative reduction equilibrium in melts.
Faculty of Chemical Engineering

Membrane separation of fermentation primary products

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
In biotechnologies, batch processes are often used, in which living cultures/biomass are used. Metabolites produced by culture are often poisonous and can damage the culture itself, as an example of which can serve ethanol fermentation. In periodic processes, the initial periods including sterilizing, nutrient dosing, etc., used to be time consuming, financially burdening. Therefore, it is desirable to dedicate an effort to develope continuous performance of such processes. One of the operations ensuring the process continualization can be membrane separation. This case brings the necessity of two membranes modules: i) microfiltration to separate solid particles-biomass and ii) pervaporation to separate primary product of fermentation, e.g., ethanol, as mentioned above. The goal of this work is to experimentally develop two step membarne separation technique, including microfiltration and pervaporation, to be prepared for an interconnection with a fermenter. THe development will be conducted from the viewpoint of chemical engineering. The reached separation parameters (selectivity, permeability) will be investigated in dependency on the process parameters (pressure, flowrate, temperature, feed composition). Chemical engineering quantities (membrain polarization module, mass transfer coefficient,...) will be used to describe these dependencies. At the workplace the new membrane modules are available, which were purchased for the purpose of this development. The PhD student will get familier both with industrial membrane module and with the custom made one. In addition to being familiar with modern technologies introduced in industry, the PhD student will also work in the team of students and academic staff who are experienced in industrial cooperation. PhD study will prepare the student to obtain either qualified working position in industry or to be able systematically conduct further research from the viewpoint of qualified chemical engineer. Further information Assoc. Prof. Tomáš Moucha, UCT Prague, building B, room T02, email: tomas.mooucha@vscht.cz
Development principles: 1. Get familiar with the principles of membrane separation processes, their physical concepts and basic mathematical description.
2. Elaborate literature search on the specifics of microfiltration and pervaporation focusing on undesirable phenomena and on the ways of their elimination.
3. Get familiar with the details of construction of microfiltration and pervaporation membrane modules in the Mass Transfer Laboratory.
4. Run a series of experiments using sufficiently wide range of operational conditions to capture the trends in their effect on the separation efficiency, for example, in terms of the membrane selectivity and module capacity.
5. Organize your experimental results into charts and graphs, which will illustrate the trends in separation efficiency with the operational parameters. Try to describe the trends by mathematical models, which could be used in the optimization of separation processes.
Faculty of Chemical Engineering

Membrane separation of fermentation primary products

Moucha Tomáš, prof. Dr. Ing. ( mou...@vscht.cz)
In biotechnologies, batch processes are often used, in which living cultures/biomass are used. Metabolites produced by culture are often poisonous and can damage the culture itself, as an example of which can serve ethanol fermentation. In periodic processes, the initial periods including sterilizing, nutrient dosing, etc., used to be time consuming, financially burdening. Therefore, it is desirable to dedicate an effort to develope continuous performance of such processes. One of the operations ensuring the process continualization can be membrane separation. This case brings the necessity of two membranes modules: i) microfiltration to separate solid particles-biomass and ii) pervaporation to separate primary product of fermentation, e.g., ethanol, as mentioned above.
The goal of this work is to experimentally develop two step membarne separation technique, including microfiltration and pervaporation, to be prepared for an interconnection with a fermenter. THe development will be conducted from the viewpoint of chemical engineering. The reached separation parameters (selectivity, permeability) will be investigated in dependency on the process parameters (pressure, flowrate, temperature, feed composition). Chemical engineering quantities (membrain polarization module, mass transfer coefficient,...) will be used to describe these dependencies. At the workplace the new membrane modules are available, which were purchased for the purpose of this development. The PhD student will get familier both with industrial membrane module and with the custom made one.
In addition to being familiar with modern technologies introduced in industry, the PhD student will also work in the team of students and academic staff who are experienced in industrial cooperation. PhD study will prepare the student to obtain either qualified working position in industry or to be able systematically conduct further research from the viewpoint of qualified chemical engineer.
Further information Assoc. Prof. Tomáš Moucha, UCT Prague, building B, room T02, email: tomas.mooucha@vscht.cz
Development principles: 1. Seznamte se s principy membránových separačních procesů, jejich fyzikálními představami a základními matematickými popisy.
2. Proveďte literární rešerši na téma specifik membránových procesů mikrofiltrace a pervaporace se zvláštním zaměřením na popis nežádoucích jevů a způsobů jejich potlačování
3. Seznamte se detailně s konstrukcí a funkcemi membránových modulů pro mikrofiltraci a pervaporaci v Laboratoři sdílení hmoty
4. Proveďte série experimentů v dostatečně širokém záběru provozních parametrů, aby bylo možno zmapovat jejich vliv na klíčové parametry pro posouzení efektivity separace jako například selektivita membrány a kapacita membránového modulu
5. Experimentální výsledky zpracujte do tabulek a grafů, ze kterých lze vysledovat trendy separační účinnosti s provozními parametry a pokuste se tyto trendy popsat matematickými modely, které je možno použít pro optimalizaci provozu studovaných separačních procesů
Faculty of Food and Biochemical Technology

Metabolomics as a tool illustrating the interactions between a plant and its microbiome

Stránská Milena, doc. Ing. Ph.D. ( zac...@vscht.cz)
Hajšlová Jana, prof. Ing. CSc. ( haj...@vscht.cz)
Microbial consortia present on agricultural plants have a major impact on their prosperity (growth, resistance to pathogens, yields, chemical composition, etc.). An important role is played by the microbial species inhabiting the plant itself (bacteria, micromycetes, yeast), as well as the relationship between the microorganism and the plant (endophyte vs. pathogen). The topic of the dissertation will include the characterization of (bio)chemical changes taking place in the system of plants and microorganisms using metabolomics, as a complex analysis of endogenous and exogenous metabolites with low molecular weight up to about 1500 Da. Attention will be focused on Vitis vinifera L. (vine) and Hordeum vulgare L. (sown barley), as one of the most important agricultural plants grown in the Czech Republic.
Faculty of Chemical Technology

Metallic materials and hydrogen

Vojtěch Dalibor, prof. Dr. Ing. ( voj...@vscht.cz)
Development principles: Problematika - kovový materiál/vodík zahrnuje dva aspekty: 1. Vliv vodíku na vlastnosti kovových konstrukčních materiálů (vysoce pevné oceli, titanové slitiny, niklové slitiny...), např. vodíkové zkřehnutí; 2.Bezpečné uskladňování vodíku absorbovaného v kovech (hořčíkové, hliníkové slitiny, slitiny vzácných kovů...) ve formě sloučenin, jejichž tepelným rozkladem se uvolňuje vodík např. pro pohon vozidel pomocí palivových článků. V rámci disertační práce budou studovány obě strany interakce kov-vodík. U technicky významných konstrukčních kovových materiálů bude studován vliv vodíku na vlastnosti, zejména mechanické (lomy, houževnatost, zkřehnutí, únava...). V další části budou navrženy a prostudovány vhodné systémy pro bezpečné uskladnění vodíku ve formě hydridů nebo jiných typů sloučenin kovů pro další použití. Disertační práce bude multioborová a bude zahrnovat řadu typů náročných experimentů - mechanické, strukturní, fázové, chemické analýzy (tah, tlak, ohyb, tvrdost, únava, LM, SEM, TEM, XRD, AFM, FA, Kelvinova sonda, absorpční/desorpční charakteristiky vodíku...). Výsledkem budou zcela nové poznatky o interakcích kovových materiálů s vodíkem použitelné jak v konstrukcích energetických a chemických zařízení, tak v moderních pohonných vodíkových systémech.
Faculty of Chemical Technology

Metallic materials prepared by advanced 3D printing technologies

Vojtěch Dalibor, prof. Dr. Ing. ( voj...@vscht.cz)
3D printing methods like selective laser melting (SLM) or other, are prospective for the fabrication of complex structural parts and medical implants because of their ability to produce very complex shapes. In the work, structures, mechanical, corrosion and biological properties of Ti based alloys, stainless or high-strength steels, biodegradable alloys or light-weight alloys prepared by various 3D printing processes will be investigated. In addition, the relationships between process parameters of 3D printing and characteristics of resulting products will be evaluated. Results of the study will propose process parameters the most suitable for obtaining desirable products. The work will also be focused on the development of novel 3D printing methods based on metal deposition.
Faculty of Food and Biochemical Technology

Methods of effective assurance of health microbiological safety, technological harmlessness and the quality of non-alcoholic beverages

Čížková Helena, doc. Ing. Ph.D. ( hel...@vscht.cz)
Šviráková Eva, Ing. Ph.D. ( svi...@vscht.cz)
In the food industry, acetic acid bacteria belonging to the Acetobacteraceae family are both health and technologically undesirable bacteria that often contaminate non-alcoholic flavoured and unflavoured beverages on different bases. For contaminated drinks, the decrease in quality is due to the occurrence of serious sensory defects. As regards to human resources, the species Acetobacter cibinongensis, Asaia bogorensis, Asaia lannensis, Gluconobacter frauterii have the status of opportunistic pathogens causing serious nosocomial infections in immunocompromised persons. The doctoral thesis is focused on the detection, characterization and identification of acetic acid bacteria isolated from non-alcoholic beverages and the production environment using modern and classical microbiological methods. The aim of the work is to contribute to refinement of laboratory control of non-alcoholic beverages during elimination of undesirable bacteria affecting its health microbiological safety, quality and durability.
Faculty of Food and Biochemical Technology

Microalgae polysaccharides: isolation, structure and biological activities

Sinica Andrej, doc. Mgr. Ph.D. ( sin...@vscht.cz)
Bleha Roman, Ing. Ph.D. ( ble...@vscht.cz)
The microalgae cultivation creates biomass, which is a potential source of biologically active compounds such as structural polysaccharides, proteins, polyphenols, carotenoids, etc. This dissertation will be focused on isolation and structural characterization of polysaccharides and biologically active metabolites of microalgae by spectroscopic, chromatographic and separation methods. Antioxidant, antitumor, immunomodulatory activities of selected compounds will be tested in cooperation with the Department of Biochemistry and Microbiology at University of Chemistry and Technology Prague.
Faculty of Chemical Technology

Micro and nanorobots based on photocatalytic materials for biomedical applications

Pumera Martin, doc. RNDr. Ph.D. ( pum...@vscht.cz)
Candidate will construct microrobots powered by chemicals for drug delivery and cancer treatment using inorganic chemistry approach. Candidate will learn how to fabricate micro and nanorobots by electrochemical and physical vapor deposition approach, how to operate and remotely control micro and nanorobots and how to chemically program them. More on www.nanorobots.cz
Faculty of Chemical Technology

Micro and nanorobots for targeted drugs delivery to cancer cells

Pumera Martin, doc. RNDr. Ph.D. ( pum...@vscht.cz)
Candidate will construct microrobots powered by chemicals for drug delivery and cancer treatment using inorganic chemistry approach based on photoactive systems. Candidate will learn how to fabricate micro and nanorobots by electrochemical and physical vapor deposition approach, how to operate and remotely control micro and nanorobots and how to chemically program them. More onwww.nanorobots.cz
Faculty of Food and Biochemical Technology

Microbial Cometabolism: Promoting Biodegradation of Pollutants

Uhlík Ondřej, doc. Ing. Ph.D. ( Ond...@vscht.cz)
Strejček Michal, Ing. Ph.D. ( str...@vscht.cz)
The objective of the proposed thesis is to test the hypothesis that secondary plant metabolites can promote cometabolism of persistent organic pollutants in the environment and thereby significantly influence the biodegradation potential of autochthonous microbial communities. In order to accomplish this objective, we will (i) selectively enrich soil bacterial consortia that will degrade selected pollutants (polychlorinated biphenyls, PCBs, and polyaromatic hydrocarbons, PAHs) when grown on secondary plant metabolites and (ii) test whether the consortia involved in secondary plant metabolite metabolism will increase the efficiency of biodegradation of PCBs and PAHs in soils.
Faculty of Food and Biochemical Technology

Microbiota of Selected Extreme Biotopes – Diversity, Ecology and Physiology

Uhlík Ondřej, doc. Ing. Ph.D. ( Ond...@vscht.cz)
Šuman Jáchym, Ing. Ph.D. ( sum...@vscht.cz)
The objective of the proposed thesis is to characterize microbial populations in extreme biotopes – chronosequence of permafrost (permafrost of differing age) and soils from salt marshes and moffettes. The characterization will be conducted by two major routes – metagenomics and modified cultivation techniques. The basic modification of the cultivation techniques will be the use of resuscitation-promoting factor and adjustment of cultivation media so that they better mimic natural conditions the bacteria are subjected to in their habitat; the goal is to increase the efficiency of the cultivation and isolate dormant or otherwise difficult-to-culture or, if possible, as-yet-uncultured bacteria.
Faculty of Chemical Engineering

Micro-cybernetics and Micro-robotics in chemistry

Mareš Jan, doc. Ing. Ph.D. ( mar...@vscht.cz)
Vrba Jan, Ing. ( Jan...@vscht.cz)
The topic of the work is focused on the development and management of the so-called microrobots and their formations. The project is based on cooperation with the Institute of Chemical Engineering, where they have been dealing with the movement of microparticles for a long time. The work assumes (i) the study of advanced methods of electron microscope image analysis, (ii) the design of specific methods and algorithms for guiding, controlling and optimizing the path of motion of microrobots and (iii) the implementation and verification.
Faculty of Chemical Engineering

Micro-cybernetics and Micro-robotics in chemistry

Mareš Jan, doc. Ing. Ph.D. ( mar...@vscht.cz)
Vrba Jan, Ing. ( Jan...@vscht.cz)
The topic of the work is focused on the development and management of the so-called microrobots and their formations. The project is based on cooperation with the Institute of Chemical Engineering, where they have been dealing with the movement of microparticles for a long time. The work assumes (i) the study of advanced methods of electron microscope image analysis, (ii) the design of specific methods and algorithms for guiding, controlling and optimizing the path of motion of microrobots and (iii) the implementation and verification.
Faculty of Chemical Engineering

Microfluidic systems for the synthesis and separation of optically active

Přibyl Michal, prof. Ing. Ph.D. ( pri...@vscht.cz)
Microfluidic reactors and separators are modern devices that represent an alternative to conventional batch and flow systems used in biotechnology. The small spatial scale ensures reproducible reaction conditions and intensive mass and heat transfer. Microfluidic devices generally lack moving parts and allow easy combination of many unit operations such as mixers, separators, reactors. The main objectives of the PhD project are: Study of kinetics of selected enzymatic reactions, which lead to production of optically active chemicals that are used in pharmacy, food industry or synthesis of chemical specialties. Design and fabrication of microfluidic separators with embedded membrane or sorbents with attached chiral selectors for separation of racemic mixtures. Testing of manufactured microfluidic devices for selective separation of selected optically active compounds. Evaluation of the possibility of accelerated transport of optically active substances through membranes by means of an imposed electric field. The lab is equipped with technologies for the production of microfluidic systems, modern measuring instruments and powerful computers. The participation of the doctoral student in grant projects and active participation in international scientific conferences is expected.
Faculty of Chemical Engineering

Microfluidic systems for the synthesis and separation of optically active chemicals

Přibyl Michal, prof. Ing. Ph.D. ( pri...@vscht.cz)
Microfluidic reactors and separators are modern devices that represent an alternative to conventional batch and flow systems used in biotechnology. The small spatial scale ensures reproducible reaction conditions and intensive mass and heat transfer. Microfluidic devices generally lack moving parts and allow easy combination of many unit operations such as mixers, separators, reactors.
The main objectives of the PhD project are:
Study of kinetics of selected enzymatic reactions, which lead to production of optically active chemicals that are used in pharmacy, food industry or synthesis of chemical specialties.
Design and fabrication of microfluidic separators with embedded membrane or sorbents with attached chiral selectors for separation of racemic mixtures.
Testing of manufactured microfluidic devices for selective separation of selected optically active compounds.
Evaluation of the possibility of accelerated transport of optically active substances through membranes by means of an imposed electric field.
The lab is equipped with technologies for the production of microfluidic systems, modern measuring instruments and powerful computers. The participation of the doctoral student in grant projects and active participation in international scientific conferences is expected.
Faculty of Food and Biochemical Technology

Microorganisms and their utilisation in waste management

Stiborová Hana, Ing. Ph.D. ( han...@vscht.cz)
Nowadays, more attention is paid to recycling and recovery of waste and therefore, the European Union has adopted a new Circular economy action plan. One option of reducing the environmental burden and decreasing the CO2 emissions in the (cement) building industry is the usage of recycled bio-concrete, which can be obtained using microbiologically induced calcite precipitation (MICP). This thesis's main goal will be to isolate and characterise suitable microorganisms and optimise MICP conditions concerning the yields, the structure and mechanical properties of bio-concrete.
Faculty of Chemical Engineering

Micro-scale mathematical modeling of gas-liquid transport in catalyst pores

Kočí Petr, doc. Ing. Ph.D. ( pet...@vscht.cz)
Isoz Martin, Ing. Ph.D. ( i...@vscht.cz)
The work focuses on the development of advanced mathematical models for simulations of mass transport in multiphase systems gas-liquid indide pores of a solid catalyst, including phase change (evaporation, condensation). The models are developed in the CFD environment OpenFOAM and utilize 3D-reconstructed structures of porous materials obtained from X-ray tomography (XRT) and electron microscopy. The model results are further verified with the available experimental data from lab reactor.
Faculty of Chemical Engineering

Micro-scale mathematical modeling of gas-liquid transport in catalyst pores

Kočí Petr, doc. Ing. Ph.D. ( pet...@vscht.cz)
Isoz Martin, Ing. Ph.D. ( i...@vscht.cz)
The work focuses on the development of advanced mathematical models for simulations of mass transport in multiphase systems gas-liquid indide pores of a solid catalyst, including phase change (evaporation, condensation). The models are developed in the CFD environment OpenFOAM and utilize 3D-reconstructed structures of porous materials obtained from X-ray tomography (XRT) and electron microscopy. The model results are further verified with the available experimental data from lab reactor.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Technology

Modeling of drug release from the solid dispersions by diffusion erosion models

Zámostný Petr, prof. Ing. Ph.D. ( zam...@vscht.cz)
This work is aimed at the study of the drug release from the solid dosage forms comprsing solid dispersions. Such formulations exhibit a well-defined structure, and the drug dissolution can be studied not only by classical dissolution techniques, but also by the apparent intrinsic dissolution. Several fronts develop in dosage forms of this type, where thos fronts corresponds to the liquid penetration, drug leaching and erosion of the residual matrix. Such processes can be described by diffusion-erosion models, which allow determining their rate controlling steps and characteristic rates to be used for the design of controlled release drugs.
Faculty of Chemical Technology

Modeling of drug release from the solid dispersions by diffusion erosion models

Zámostný Petr, prof. Ing. Ph.D. ( zam...@vscht.cz)
This work is aimed at the study of the drug release from the solid dosage forms comprsing solid dispersions. Such formulations exhibit a well-defined structure, and the drug dissolution can be studied not only by classical dissolution techniques, but also by the apparent intrinsic dissolution. Several fronts develop in dosage forms of this type, where thos fronts corresponds to the liquid penetration, drug leaching and erosion of the residual matrix. Such processes can be described by diffusion-erosion models, which allow determining their rate controlling steps and characteristic rates to be used for the design of controlled release drugs.

Study Programme:

Faculty of Food and Biochemical Technology

Modeling of rheological properties of dairy products.

Štětina Jiří, doc. Ing. CSc. ( ste...@vscht.cz)
Faculty of Chemical Engineering

Modeling of ultrafast processes in radiation chemistry

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The enormous experimental development allows for a direct study of electron photoemission from water and solutions. New, hithertho unknown phenomena have emerged. The Intermolecular Coulomb Decay represents one example. The new phenomena can give rise to novel spectroscopies or to application in radiooncology. The proposed Thesis will focus on the exploration of these phenomena, using the methods of quantum theory of molecules and molecular simulations. For more information, see http://photox.vscht.cz/
Faculty of Chemical Engineering

Modeling of ultrafast processes in radiation chemistry

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The enormous experimental development allows for a direct study of electron photoemission from water and solutions. New, hithertho unknown phenomena have emerged. The Intermolecular Coulomb Decay represents one example. The new phenomena can give rise to novel spectroscopies or to application in radiooncology. The proposed Thesis will focus on the exploration of these phenomena, using the methods of quantum theory of molecules and molecular simulations. For more information, see http://photox.vscht.cz/
Faculty of Chemical Engineering

Modelling of interactions in colloidal systems by Discrete Element Methods

Kosek Juraj, prof. Dr. Ing. ( Jur...@vscht.cz)
Zubov Alexandr, Ing. Ph.D. ( Ale...@vscht.cz)
Various particulate dispersions in liquid phase, e.g., suspensions or emulsions, are found in many products starting from polymer latexes through personal care up to paints and food products. The first aim of this project is to advance our particle-based computer modelling and address numerous challenges. This will be possible due to on-going parallelization of DEM code allowing to calculate at realistic shear-rates.

Examples of open challenges are: (i) rheology and stability of dispersions stabilized by non-ionic surfactants, (ii) formation of colloidal gels, (iii) extensional rheology of concentrated dispersions, (iv) electrostatic charging of dielectric particle-liquid dispersions, (v) formulation of kernels for population balance modelling, and (vi) application of dispersions in energy-storage applications based on metal-air electrochemical cells.

PhD student will become familiar with not only polymer reaction and material engineering, polymer physics, physical chemistry, fluid mechanics and colloid science, but will also advance his/her mathematical modeling skills. The project will be conducted not only with the research team in our research laboratory, but also with partners from European companies and universities. This project is going to be supported by grant projects and contractual research.

Info: phone +420 220 44 3296, office B-145, e-mail jkk@vscht.cz, web http://kosekgroup.cz
Faculty of Chemical Engineering

Modelling of nuclear quantum effects in spectroscopy

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The Thesis will focus on method development for simulations of spectral properties with a special attention paid to the nuclear quantum effects. The role of nuclear quantum effects on molecular structure and thermodynamics will be explored, too. For more information, see http://photox.vscht.cz.
Faculty of Chemical Technology

Molecular composites of polyamides

Brožek Jiří, prof. Ing. CSc. ( bro...@vscht.cz)
The work is focused on preparation posibilities of molecular composites polyamide 6/other polyamides and their characterization. Polyamide acts as a matrice in these materials and other polyamide is scattered in the matrice and can change properties of materials. These composites offer variability in materials properties and fullfil demands on special polymers.
Faculty of Chemical Engineering

Molecular Simulations of Atmospheric Aerosols

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
Atmosphere of Earth is a unique chemical reactor. Light induced reactions play a prominent role in the intiation of many important chemical reactions. Many of the atmospheric processes also take place within heterogeneous processes, e.g. on the surface of aerosols or dust particles. The project focuses on theoretical modeling of chemical and photochemical processes in the stratosphere and in the troposhere. The whole toolbox of theoretical methods will be used within the project. For more information, see http://photox.vscht.cz/
Faculty of Chemical Engineering

Molecular Simulations of Atmospheric Aerosols

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
Atmosphere of Earth is a unique chemical reactor. Light induced reactions play a prominent role in the intiation of many important chemical reactions. Many of the atmospheric processes also take place within heterogeneous processes, e.g. on the surface of aerosols or dust particles. The project focuses on theoretical modeling of chemical and photochemical processes in the stratosphere and in the troposhere. The whole toolbox of theoretical methods will be used within the project. For more information, see http://photox.vscht.cz/
Faculty of Chemical Engineering

Molecular simulations of electrode-electrolyte interface

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The thesis will focus on theoretical study of the interfaces between the electrode material and electrolytes. Extremely concentrated electrolytes will be studied as well, especially in the context of novel energy sources. The work will include techniques of quantum chemistry and statistical mechanics. For more information, see http://photox.vscht.cz/
Faculty of Chemical Engineering

Molecular simulations of electrode-electrolyte interface

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The thesis will focus on theoretical study of the interfaces between the electrode material and electrolytes. Extremely concentrated electrolytes will be studied as well, especially in the context of novel energy sources. The work will include techniques of quantum chemistry and statistical mechanics. For more information, see http://photox.vscht.cz/
Faculty of Food and Biochemical Technology

Monitoring of the assessors sensitivity to selected tastes

Doležal Marek, doc. Dr. Ing. ( dol...@vscht.cz)
Ilko Vojtěch, Ing. Ph.D. ( I...@vscht.cz)
Taste is a sensory modality that leads organisms to identify and consume nutrients and avoid toxins and indigestible materials. How taste (taste perception) works has not yet been fully explored, because the perception of the taste of food and drink results from complex interactions between individual sensory systems. In addition to the hitherto recognized basic tastes, a fatty taste which lies at the interface between somatosensory and taste perception can also be detected by means of dedicated receptors through taste cups. For many years, the recognition of fat in food has been considered primarily a function of its structure, and thus of somatosensory origin. Because specific membrane receptors have been described on taste bud cells for the detection of free fatty acids, a fatty taste is likely to be considered another basic taste.
The work will be realized mainly in the sensory laboratory, which is equipped according to the relevant international standard ISO 8589. Part of the work will be monitoring the sensitivity of the assessors to selected tastes. Attention will be paid especially to the fatty taste and the effect of fatty acids on the taste perception, the sensitivity of the assessors to the metallic taste of zinc salts and substances that mask individual tastes.
Faculty of Environmental Technology

Monitoring the occurrence and fate of antibiotic resistance genes in wastewater and the environment

Bartáček Jan, doc. Ing. Ph.D. ( jan...@vscht.cz)
The spread of antibiotic resistance is one of the world's most pressing health-related problems. Every year, the number of patients who cannot be treated with standard antibiotic treatment, because they are infected with antibiotic-resistant strains of bacteria, is growing. Wastewater and sewage sludge are one of the most important ways of introducing antibiotic resistance (in the form of resistant pathogenic bacteria or their genetic information - antibiotic resistance genes) into the environment.
This work will deal with the monitoring of antibiotic resistance genes in wastewater, their removal in wastewater treatment plants, and their fate after they enter the environment. The main monitored environments will be sediments of wastewater recipients and soil irrigated with recycled wastewater.
Faculty of Chemical Technology

Multicomponent silicate and borate structures to be used in thermal neutrons detection

Jakeš Vít, Ing. Ph.D. ( jak...@vscht.cz)
This work will be focused on multi-component silicate and borate structures with substitution of activator ions in order to increase the phase and chemical resistivity of the material and to improve the scintillation response in the detection of neutron radiation.
Faculty of Environmental Technology

Multifunctional heterogeneous catalysts for biomass valorization

Kubička David, doc. Ing. Ph.D., MBA ( Dav...@vscht.cz)
The complexity of biomass-derived raw materials necessitates the development of novel catalysts with several cooperative catalytic functionalities. The work will focus on designing, synthesizing, and characterizing multifunctional catalysts and evaluating their catalytic activity, selectivity, and stability in the transformation of biomass-derived raw materials (such as furfural, 5-hydroxymethylfurfural, or levulinic acid) to value-added chemicals and/or advanced biofuels. The main attention will be directed at understanding the relationships between catalyst synthesis and its structure and properties as well as between catalyst structure and properties and its performance.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Technology

Nanoparticulate formulation approaches for topical delivery

Zbytovská Jarmila, doc. Mgr. Dr.rer.nat. ( zby...@vscht.cz)
Human skin represents a unique protecting barrier which, however, limits the trans/dermal drug delivery. Nanoparticulate systems show a great potential to improve drug permeation across the skin barrier, though their exact interaction mechanism with the skin barrier has not been fully understood yet. The aim of this work will be development and characterization of advanced nanoparticulate systems containing selected actives. Effectivity of the formulations will be determined in vitro on isolated skin or by other techniques. For deeper understanding interactions between the nanoparticles and skin barrier, biophysical techniques (e.g. infrared and Raman spectroscopy or X-ray diffraction) will be applied. The main outputs of the work will be effectivity evaluation of the particular formulation approaches and elucidating of interactions between the nanoparticles and skin barrier.

Study Programme:

Faculty of Chemical Engineering

Nanostructured biomimetic surfaces with antibacterial effect

Tokárová Viola, Ing. Ph.D. ( vio...@vscht.cz)
Biomimetic materials developed thanks to new technologies have a unique function inspired by the biomaterials and their structure occurring in nature. One of the areas of biomimetics is topographic surfaces with antibacterial property. The subject of the work is the mapping of the topography of natural materials, such as the wings of selected representatives of dragonflies or rose petals and replication of the structures into suitable material that can be applied in biomedicine (e.g., implants). The aim is to focus on nanostructured topography and to characterize both surfaces, natural and replicated, and to test antibacterial property of replicas against different bacterial strains (e.g. infections associated with postoperative medical care).
Faculty of Chemical Engineering

Nanostructured biomimetic surfaces with antibacterial effect

Tokárová Viola, Ing. Ph.D. ( vio...@vscht.cz)
Biomimetic materials developed thanks to new technologies have a unique function inspired by the biomaterials and their structure occurring in nature. One of the areas of biomimetics is topographic surfaces with antibacterial property. The subject of the work is the mapping of the topography of natural materials, such as the wings of selected representatives of dragonflies or rose petals and replication of the structures into suitable material that can be applied in biomedicine (e.g., implants). The aim is to focus on nanostructured topography and to characterize both surfaces, natural and replicated, and to test the antibacterial property of replicas against different bacterial strains (e.g. infections associated with postoperative medical care).
Faculty of Chemical Technology

Nanostructured/ composite materials based on TiO2 for photocatalytic processes in gaseous phase

Krýsa Josef, prof. Dr. Ing. ( kry...@vscht.cz)
Baudys Michal, Ing. Ph.D. ( bau...@vscht.cz)
Air polution represents a significant problem which can be conveniently solved by an application of photocatalytic processes. Therefore the aim of the present thesis is the preparation of new photocatalytically active composite materials based on TiO2 and the determination of their adsorption and photocatalytic properties. Titanium dioxide nanotubes prepared by anodic oxidation show a larger active area (compared to planar samples), allowing more efficient removal of polutants from the gaseous phase. The influence of various modifications of TiO2 nanotubes and of operating parameters (flow, humidity and UV intensity) on photocatalytic efficiency will be investigated. The goal is to get the material having at the same time good adsorption properties and at the same time a high ability to remove unwanted volatile substances in the air. Part of the work will use the standard ISO tests for monitoring the kinetics of oxidation reactions (NOx, VOCs) on the surface of the prepared photocatalysts. The important part is the characterization of materials/coatings (XRD, SEM, BET, Raman spectroscopy) and further development of methods allowing the testing of functional properties of the prepared materials/coatings in air treatment.
Faculty of Chemical Technology

Nanostructured/ composite materials based on TiO2 for photocatalytic processes in gaseous phase

Krýsa Josef, prof. Dr. Ing. ( kry...@vscht.cz)
Baudys Michal, Ing. Ph.D. ( bau...@vscht.cz)
Air polution represents a significant problem which can be conveniently solved by an application of photocatalytic processes. Therefore the aim of the present thesis is the preparation of new photocatalytically active composite materials based on TiO2 and the determination of their adsorption and photocatalytic properties. Titanium dioxide nanotubes prepared by anodic oxidation show a larger active area (compared to planar samples), allowing more efficient removal of polutants from the gaseous phase. The influence of various modifications of TiO2 nanotubes and of operating parameters (flow, humidity and UV intensity) on photocatalytic efficiency will be investigated. The goal is to get the material having at the same time good adsorption properties and at the same time a high ability to remove unwanted volatile substances in the air. Part of the work will use the standard ISO tests for monitoring the kinetics of oxidation reactions (NOx, VOCs) on the surface of the prepared photocatalysts. The important part is the characterization of materials/coatings (XRD, SEM, BET, Raman spectroscopy) and further development of methods allowing the testing of functional properties of the prepared materials/coatings in air treatment.
Faculty of Chemical Technology

Nanostructures based on MXene type layered carbides

Sofer Zdeněk, prof. Ing. Ph.D. ( Zde...@vscht.cz)
This thesis is focused on the preparation of layered MAX phases with general composition M1+yAXy, where M is transition metal, A is metal or semi-metal from the group of p-elements (Al, Si, Ge) and X is carbon or nitrogen. MAX phases have a unique layered structure which can be chemically exfoliated to monolayers of MXens with general composition M1+yXy. Their surface can be stabilized by various functional groups. Student will work on the development of new methods for synthesis of MAX phases (SPS methods, high-temperature ceramic synthesis) and the processes of chemical exfoliation and surface functionalization. The prepared materials will be tested for applications in energetic (hydrogen evolution, Li and Na batteries, and membranes for hydrogen separation or supercapacitors). The influence of composition and structure on their properties will be studied as well.
Faculty of Chemical Engineering

Natural Fibre Reinforced Thermoplactics for Structural Applications

Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
The recent increase in use of woven fibre composites is a direct outcome of technical advances in materials development and manufacturing technologies. This class of composites is of intense interest for applications in operational structures, where durability and damage tolerance are first-rank considerations; thus, understanding damage is of key importance for applications where the ability to maintain structural health during operational life andthusincreasing overall reliability are top priorities. In spite of this, the study of their mechanical properties, in particular the damage resistance of these materials, is still in its infancy, and one of the main sourcesof conservatism in their use is uncertainty regarding damage characterization and failure initiation. Existing work on short (unwoven) vegetal-fibre composites shows that incorporation of vegetal fibres shows great promise. This study will focus on fabrication and failure characterization vianNon-DdestructiveEevaluation (NDE) of an emerging class of laminated composite materials, viz. those based on a thermoplastic matrix reinforced with woven vegetable-based fibre fabric layers. A particular focus will be given to flax fibre fabrics included in a thermoplastic acrylic matrix byvVacuum-aAssistedrResiniInfusion (VARI). Such composites have the following advantages: i) the use of bio-based and biodegradable fibres as replacement for conventional synthetic fibres, ii) the use of a recyclable matrix by crushing/reshaping or depolymerisation, iii) therRoom-tTemperature (RT) manufacturing process that may limit thermal degradation of the flax fibre (including its physicochemical treatment) despite the inherent heat release induced by the matrix polymerization. To reach optimal mechanical properties in terms of stress transfer from matrix to fibre, good fibre-matrix interface compatibilization and adhesion will be required. Once composite manufacturing is optimized, a manufacturability of these materials and their failure during their life cycle will be performed.
Faculty of Chemical Engineering

Naturally sourced particles for drug encapsulation and delivery

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Drug encapsulation into a suitable carrier particle is a common method used in situations where it is possible to either modify the surface properties (e.g. powder flowability or dispersibility in water), to protect the encapsulated component from the environment (e.g. enzymatic digestion in the GI tract) or to control the rate of drug release. Several man-made encapsulation processes are known. However, there are also many natural systems that rely on encapsulation – the cell walls of single cell organisms or their spores, natural particles such as pollen, extra-cellular vesicles, or sub-cellular structures such as vacuoles or other organelles. Some of these structures are highly specific in terms of drug diffusion and its selectivity, or in terms of recognition by cells of the immune system e.g. due to specific shape of the presence of immunomodulatory functional groups on the surface. Yeast glucan particles can serve as a prime example. The aim of this inter-disciplinary project is to investigate the potential of several different types of naturally sourced particles in drug formulation and drug delivery. Both cell-wall derived particles and organelle-based particles will be considered. Special attention will be paid to the process of particle extraction and isolation, as well to the drug encapsulation methodology.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

Naturally sourced particles for drug encapsulation and delivery

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Drug encapsulation into a suitable carrier particle is a common method used in situations where it is possible to either modify the surface properties (e.g. powder flowability or dispersibility in water), to protect the encapsulated component from the environment (e.g. enzymatic digestion in the GI tract) or to control the rate of drug release. Several man-made encapsulation processes are known. However, there are also many natural systems that rely on encapsulation – the cell walls of single cell organisms or their spores, natural particles such as pollen, extra-cellular vesicles, or sub-cellular structures such as vacuoles or other organelles. Some of these structures are highly specific in terms of drug diffusion and its selectivity, or in terms of recognition by cells of the immune system e.g. due to specific shape of the presence of immunomodulatory functional groups on the surface. Yeast glucan particles can serve as a prime example. The aim of this inter-disciplinary project is to investigate the potential of several different types of naturally sourced particles in drug formulation and drug delivery. Both cell-wall derived particles and organelle-based particles will be considered. Special attention will be paid to the process of particle extraction and isolation, as well to the drug encapsulation methodology.

Study Programme:

Faculty of Chemical Technology

New method of in vitro test of glass and glass-ceramic materials for bone tissue replacement

Rohanová Dana, doc. Dr. Ing. ( dan...@vscht.cz)
Horkavcová Diana, Ing. Ph.D. ( dia...@vscht.cz)
Substitution of hard bone tissue by glass, glass-ceramic, or ceramics material is a common practice today. Each, potentially bioactive material has to be studied by a series of in vitro and in vivo tests. In vitro tests used for an inorganic biomaterial is now described in ISO 23317:2014. Nowadays, this standard is obsolete and needs a general revision. The recommended form of the tested material (solid discs) and testing solution (Simulated Body Fluid - SBF) seems to be not suitable. SBF simulates the inorganic part of blood plasma and is buffered with TRIS+HCl buffer. However, this buffer interacts with the tested glass and shifts the in vitro test results to false-positive values. This work will be focused on the setting of the new conditions of in vitro tests for better characterization of tested biomaterials.
Faculty of Chemical Technology

New methods of C-O bond activation for advanced cross-coupling reactions

Tobrman Tomáš, doc. Ing. Ph.D. ( tom...@vscht.cz)
Cross-coupling reactions are part of modern chemistry. During cross-coupling reactions, the starting material, which contains a reaction center (e.g., an activated C-O bond), is modified to the reaction product by the action of a suitable reagent in the presence of a catalyst. The aim of this work is to increase the atomic economy by cross-coupling reactions of substances with activated C-O bond. During the project, new types of reaction centers represented by activated C-O bonding will be designed. For these substances, the cross-coupling reaction will be conducted so as to selectively form two easily separable products.
Faculty of Chemical Engineering

New nanostructured carbon nanotubes-based composite membranes for selective gas separation

Friess Karel, doc. Ing. Ph.D. ( fri...@vscht.cz)
Membrane separation processes (MSP) belong to the modern technologically significant separation methods. Furthermore, MSP are less economical demanding and more eco-friendly industrial processes compared to the conventional separation techniques used in chemical, petrochemical, pharmaceutical and food industries. The most significant industrial applications of MSP for gas separation are focused on the separation of helium from natural gas, separation of hydrogen from hydrocarbons, carbon monoxide or nitrogen and also for removing carbon dioxide from biogas or organic vapours from the air. Generally, single-wall carbon nanotubes (SWCNT) and graphene oxide (GO) based membrane materials belong to the modern and dynamically growing group of materials that have many interesting properties. Especially, this work will be targeted on SWCNT-GO-based separation of hydrogen from carbon dioxide or from other gases. Our laboratory is focused on the topic of membrane separation for more than 15 years. Currently, we participate in two grant projects of the GA CR aimed at increasing the efficiency of membrane separation processes. This doctoral thesis is thematically linked to these projects. The thesis will be focused on the study of theoretical and experimental aspects of the transport of gases and their mixtures in GO and polymer-based membranes.
Development principles: 1) Literature search 2) Performing of permation and sorption experiments of H2, CO2 and others selected gases (He, Ar, O2, N2, CH4, C3H6, C3H8, C4H10, and SF6) in composite membranes 3) Evaluation and elaboration of determined experimental data and calculation of transport parameters (coefficients of permeability, diffusion and sorption) 4) modelling of gas transport 5) PhD thesis writing
Faculty of Chemical Engineering

New polymers for membrane separations of difficultly separable mixtures

Vopička Ondřej, doc. Ing. Ph.D. ( vop...@vscht.cz)
Dendisová Marcela, Ing. Ph.D. ( Mar...@vscht.cz)
Development principles: 1) Literární rešerše na téma struktura a vlastnosti polymerů používaných pro membránové separace.
2) Příprava polymerů a nano-kompozitů, optimalizace složení.
3) Charakterizace strukturních, mechanických, tepelných charakteristik polymerů a jejich interakcí s dělenými látkami.
4) Měření separačních charakteristik polymerních filmlů pro obtížně separovatelné směsi - eutektika, směsi blízkovroucích látek, izomery, azeotropy.
5) Prezentování výsledků, sepsání doktorské práce a její obhajoba.
Faculty of Food and Biochemical Technology

New possibilities for prediction of beer colloidal stability

Dostálek Pavel, prof. Ing. CSc. ( Pav...@vscht.cz)
Štětina Jiří, doc. Ing. CSc. ( ste...@vscht.cz)
One of the limiting factors of beer stability is its colloidal stability. The colloidal stability of beer is determined by the composition of the colloidal system of beer and is influenced by other factors. The aim of this work is to find such methods of characterization of the colloidal system of beer that would allow us to predict its colloidal stability during the time. Another aim of the work is to find the reasons for reduced colloidal stability in different kinds of beers.
Faculty of Chemical Technology

New tool steels and their processing by non-conventional techniques

Novák Pavel, doc. Ing. Ph.D. ( pan...@vscht.cz)
Tool steels reach very good mechanical properties, especially hardness and wear resistance, due to the content of carbide-forming elements and suitable heat treatment. The used scale of the carbide-formers comprises W, V, Mo and Cr, while some of them (W, V) are currently listed as critical raw materials by European commission. So it is desirable to substitute them. The suibstitution of the alloying elements is the subject of research for many years for various reasons and led to the formation of many grades of currently used tool steels. However, some of the potential alloying elements cause problems during processing by conventional metallurgical routes. This work is focused on the development of a new tool steel alloyed by non-conventional elements, aiming to form the material, which will be interesting from the viewpoints of both the mechanical proporties and the sustainability. For the processing, the techniques comprising 3D printing by "Direct Energy Deposition" method, which application for high-carbon tool steel will be unique, and the powder metallurgy methods comprising melt atomization or mechanical alloying and spark plasma sintering.
Faculty of Food and Biochemical Technology

Novel approaches in the elimination of cancer cells and bacterial biofilms

Zelenka Jaroslav, doc. Ing. Ph.D. ( ZEL...@vscht.cz)
Faculty of Food and Biochemical Technology

Novel glycomimetics as inhibitors of galectins

Parkan Kamil, Ing. Ph.D. ( par...@vscht.cz)
Carbohydrates are structurally diverse group of natural products which play an important role in numerous biological processes, including immune regulation, infection, and cancer metastasis. Unfortunately, native carbohydrates suffer from inherently weak binding affinities and poor pharmacokinetic properties. To enhance their potential as drug candidates, glycomimetics have been developed. They are more drug-like compounds, which mimic the structure and function of native carbohydrates. However, the advancement in carbohydrate research is relatively slow due to the problems associated with the complexity of carbohydrates structures and the lack of general synthetic methods. This problem could be solved using photoinduced chemistry under catalytic conditions. The use of photocatalysis is heading towards “greener” chemistry, where enhanced synthetic efficiency through the reduction of unnecessary waste is attained.
The goal of the PhD project will be the development of synthetic methodologies for the preparation of various biologically prospective glycomimetics with affinity towards galectins (Gal-1, Gal-3, Gal-7), which are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy, and signaling.
Faculty of Chemical Technology

Nucleophilic Fluorination Reagents Based on Hypervalent Silicon Compounds

Kvíčala Jaroslav, prof. Ing. CSc. ( kvi...@vscht.cz)
Rybáčková Markéta, Ing. Ph.D. ( ryb...@vscht.cz)
Fluorinated compounds play irreplaceable role in pharmaceutical chemistry and agrochemistry, whereas still higher emphasize is given to enantiomerically pure compounds. While nucleophilic fluorination belongs to basic methods of the synthesis of fluorinated compounds, asymmetric fluorination of sp3 centres and fluorination of aromatic ring still remain a challenge regarding chemo-, regio- and stereoselectivity. As a part of joint bilateral project, the work is aimed in the synthesis and applications of new more efficient and selective reagents based on hypervalent silicon compounds or fluoroimidazolidines. Asymmetric modifications of the reagents will use with advantage new chiral [2.2]paracyclophanes and triptycenes. Apart of experimental organic chemistry, 19F and 29Si NMR spectroscopy, as well as computational chemistry will be applied for the study of the synthesized compounds.
Faculty of Chemical Technology

Nucleophilic Fluorination Reagents Based on Hypervalent Silicon Compounds

Kvíčala Jaroslav, prof. Ing. CSc. ( kvi...@vscht.cz)
Rybáčková Markéta, Ing. Ph.D. ( ryb...@vscht.cz)
Fluorinated compounds play irreplaceable role in pharmaceutical chemistry and agrochemistry, whereas still higher emphasize is given to enantiomerically pure compounds. While nucleophilic fluorination belongs to basic methods of the synthesis of fluorinated compounds, asymmetric fluorination of sp3 centres and fluorination of aromatic ring still remain a challenge regarding chemo-, regio- and stereoselectivity. As a part of joint bilateral project, the work is aimed in the synthesis and applications of new more efficient and selective reagents based on hypervalent silicon compounds or fluoroimidazolidines. Asymmetric modifications of the reagents will use with advantage new chiral [2.2]paracyclophanes and triptycenes. Apart of experimental organic chemistry, 19F and 29Si NMR spectroscopy, as well as computational chemistry will be applied for the study of the synthesized compounds.
Faculty of Food and Biochemical Technology

Nutraceuticals and foods that reduce oxidative and carbonyl stress

Cejpek Karel, doc. Dr. Ing. ( cej...@vscht.cz)
The subject are components of food and nutraceuticals that are able to reduce the redox potential and the amount of reactive carbonyl compounds formed as products of sugars transformation. The active components can act as reducing agents (or different antioxidants) and reagents able to scavenge reactive carbonyl species (RCS) in both food and in vivo. RCS are formed during non-enzymatic browning reactions in food (Maillard reaction) and in vivo (glycation) as well as due to lipid oxidation. The goal is finding foods and nutraceuticals that may significantly suppress the above-mentioned kinds of stress promotors and identifying active compounds, which are behind these effects.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

Oleogels for drug delivery

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Řehoř Ivan, RNDr. Ph.D. ( REH...@vscht.cz)
Oleogels, like hydrogels, are semi-solid materials that can contain up to 99 % of a liquid, which is solidified by a three-dimensional polymer network. While hydrogels contain as the liquid and the polymers are hydrophilic, oleogels contain oil and an oleophilic polymer network. Many APIs that are poorly soluble in water could potentially be formulated using oleogels and be either directly dissolved in the oil phase or form a particle depot that would dissolve in the oil gradually and act as a longer-lasting reservoir. The aim of this project is to evaluate the suitablitity of selected oleogel formulations for drug delivery applications from the point of view of manufacturability, drug release kinetics, drug stability, and biological compatibility. The application of oleogels will be demonstrated using several selected APIs both in vitro and in vivo.

Study Programme:

Faculty of Chemical Engineering

Oleogels for drug delivery

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
Oleogels, like hydrogels, are semi-solid materials that can contain up to 99 % of a liquid, which is solidified by a three-dimensional polymer network. While hydrogels contain as the liquid and the polymers are hydrophilic, oleogels contain oil and an oleophilic polymer network. Many APIs that are poorly soluble in water could potentially be formulated using oleogels and be either directly dissolved in the oil phase or form a particle depot that would dissolve in the oil gradually and act as a longer-lasting reservoir. The aim of this project is to evaluate the suitablitity of selected oleogel formulations for drug delivery applications from the point of view of manufacturability, drug release kinetics, drug stability, and biological compatibility. The application of oleogels will be demonstrated using several selected APIs both in vitro and in vivo.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Engineering

On-line measurement and control of continuous pharmaceutical manufacturing

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
The manufacturing of pharmaceutical products is typically carried out batch-wise. While this makes sense for products that are manufactured only occasionally in small quantities, batch processes also have several drawbacks. These include excessive dead-times, need for cleaning to avoid cross-contamination, and generally poorer control over the product quality. By switching pharmaceutical manufacturing to a continuous mode, equipment utilisation can be increased theoretically to 100 %, the footprint of the facilities can be substantially reduced, and standard feed-back and feed-forward control schemes applied. A crucial component of continuous manufacturing processes is on-line measurement of key quality attributes such as particle size distribution, composition uniformity of granular blends, or moisture content. Advanced analytical instruments such as Near-Infrared probes can be used for this purpose. The aim of this project is to explore the on-line measurement and control methods for continuous pharmaceutical manufacturing in an industrial setting and combine them with computer simulation tools in order to optimize the overall process robustness and operability.

Study Programme:

Faculty of Chemical Engineering

On-line measurement and control of continuous pharmaceutical manufacturing

Štěpánek František, prof. Ing. Ph.D. ( Fra...@vscht.cz)
The manufacturing of pharmaceutical products is typically carried out batch-wise. While this makes sense for products that are manufactured only occasionally in small quantities, batch processes also have several drawbacks. These include excessive dead-times, need for cleaning to avoid cross-contamination, and generally poorer control over the product quality. By switching pharmaceutical manufacturing to a continuous mode, equipment utilisation can be increased theoretically to 100 %, the footprint of the facilities can be substantially reduced, and standard feed-back and feed-forward control schemes applied. A crucial component of continuous manufacturing processes is on-line measurement of key quality attributes such as particle size distribution, composition uniformity of granular blends, or moisture content. Advanced analytical instruments such as Near-Infrared probes can be used for this purpose. The aim of this project is to explore the on-line measurement and control methods for continuous pharmaceutical manufacturing in an industrial setting and combine them with computer simulation tools in order to optimize the overall process robustness and operability.
Faculty of Food and Biochemical Technology

Optimizing the production of fermented foods

Ševčík Rudolf, doc. Ing. Ph.D. ( sev...@vscht.cz)
The project will focus on the development and optimization of the production of fermented foods (meat, fruit and vegetable products). The basic factors affecting the quality and safety of fermented products are: starter cultures, quality of used raw materials, microbial contamination of raw materials, recipe, technological processes, fermentation conditions, packaging and distribution conditions. As part of the project, new recipes will be developed and the production of processes will be optimized, including selection and dosing of suitable starter cultures, packaging and distribution of fermented meat, fruit and vegetable products. Within the project, individual technological processes will be optimised, both in a pilot plant environment and at individual food manufacturers.
Faculty of Chemical Engineering

Particle Based Modeling of Diffusion, Rheological, Interfacial and Relaxation Properties of Polymers

Kosek Juraj, prof. Dr. Ing. ( Jur...@vscht.cz)
Zubov Alexandr, Ing. Ph.D. ( Ale...@vscht.cz)
Dissipative particle dynamics (DPD) is a stochastic modeling technique for simulating of simple and complex fluids. It is being used to tackle hydrodynamic time and space scales beyond those available with molecular dynamics. DPD is an off-lattice meso-scale simulation technique considering particles moving in a continuous space, where particles represent whole molecules, segments of molecules or fluid regions, rather than single atoms. DPD gives access to simulation of polymer fluids with volumes up to 100 nm in linear dimension for up to a millisecond.

This PhD project is at intersection of many challenges in chemical and polymer reactor engineering. Examples of these challenging problems are: · Diffusion flux supplying monomer(s) in catalytic polymerization is limited by finite molecular and/or segmental motion and not by constitutive equations analogous to Fick’s law. If this hypothesis is confirmed then it will provide a key to explanation of kinetic data obtained over many decades. And standard textbooks of chemical engineering will be changed. · Rheology of concentrated polymer solutions (e.g., polymer swollen by monomer(s)) is an open problem important to suspension polymerization or foaming of polyurethanes. · Diffusion of polymer segments and interfacial phenomena are a key to understanding of phase separation in individual latex nanoparticles in emulsion copolymerization producing high-value specialty products. · Systematic understanding of penetrant diffusion in polyolefins including its temperature dependence and interplay between diffusion and relaxation dynamics is another problem with a pool of available experimental data but insufficient underlying theories.

PhD student will become familiar with not only polymer reaction and material engineering, polymer physics, physical chemistry, fluid mechanics and colloid science, but will also advance his/her mathematical modeling skills. The project will be conducted not only with the research team in our research laboratory, but also with partners from European companies and universities. This project is going to be supported by grant projects and contractual research.

Info: phone +420 220 44 3296, office B-145, e-mail jkk@vscht.cz, web http://kosekgroup.cz
Faculty of Food and Biochemical Technology

Penetration of coumpands into skin depending on their structure

Šmidrkal Jan, prof. Ing. CSc. ( jan...@vscht.cz)
Hrádková Iveta, Ing. Ph.D. ( ive...@vscht.cz)
Components of cosmetic products penetrate to the different layers of skin. Depth of their penetration depends on their molecular weight and also on their polarity. Small and lipophilic molecules penetrate in deeper layers of the skin, while large and hydrophilic molecules remain in the surface layers of the skin.
The aim of this thesis is determination of penetration depth of substances used in cosmetic products by two different methods – method of skin layer stripping and permeation method of using Franz cells.
Faculty of Chemical Engineering

Percolation oxidic structures based on heterojunctions: application in sensing of toxic gases

Vrňata Martin, prof. Ing. Dr. ( vrn...@vscht.cz)
Fitl Přemysl, Ing. Ph.D. ( f...@vscht.cz)
During recent years there is a remarkable progress in the development of oxidic gas-sensing structures. In the terms of electric properties - instead of "conventional" homogeneous resistors based on one oxidic phase, more frequently the heterojunctions are utilized, that are formed by grains of two different oxides with different bandgaps. Thus the sensitive layer of resulting sensor has a character of two- or three- dimensional percolation structure. To ensure the proper functionality of such a structure, two critical requirements have to be fulfilled: a) total separation of both oxidic phases; b) grain dimensions in the order of units of microns. On interaction of detected gas with the above described heterostructure, the energy-barrier height on heterojunction is modified and, simultaneously, dramatic modulation of conductivity of both phases occurs. As a result, the "integral" value of electric resistance of such a sensor is changed by several orders of magnitude. This thesis is focused on: (i) preparation of oxidic heterostructures by thermal oxidation method; (ii) characterization of gas-sensing properties of these sensors.

Synthesis and Production of Drugs - Drugs and Biomaterials

Study Programme: Synthesis and Production of Drugs

Faculty of Chemical Technology

Pharmaceutical substances crystal structure solution by combination of data from ss-NMR, structure prediction and powder diffraction

Hušák Michal, doc. Dr. Ing. ( hus...@vscht.cz)
When we have no singe crystal diffraction data available we can solve the structure from alternative experiments. We can predict the structure and confirm the prediction by experimental and theoretical ss-NMR data comparison. The process can be combined with data obtained by powder diffraction. The target of this work is to test this synthetic approach for crystal structure solution.
Faculty of Chemical Technology

Pharmaceutical substances crystal structure solution by combination of data from ss-NMR, structure prediction and powder diffraction

Hušák Michal, doc. Dr. Ing. ( hus...@vscht.cz)
When we have no singe crystal diffraction data available we can solve the structure from alternative experiments. We can predict the structure and confirm the prediction by experimental and theoretical ss-NMR data comparison. The process can be combined with data obtained by powder diffraction. The target of this work is to test this synthetic approach for crystal structure solution.
Faculty of Chemical Technology

Pharmaceutical substances chirality identification from powder diffraction data

Hušák Michal, doc. Dr. Ing. ( hus...@vscht.cz)
Pharmaceutically interesting compounds are often not available in a form of crystals suitable for single crystal X-ray structure determination. The structure can be determined from powder - unfortunately standard experiment make chirality determination impossible. The main aim of this work will be to calibrate the crystal structure by adding an ion or cocrystallization partner with known chirality.
Faculty of Chemical Technology

Pharmaceutical substances chirality identification from powder diffraction data

Hušák Michal, doc. Dr. Ing. ( hus...@vscht.cz)
Pharmaceutically interesting compounds are often not available in a form of crystals suitable for single crystal X-ray structure determination. The structure can be determined from powder - unfortunately standard experiment make chirality determination impossible. The main aim of this work will be to calibrate the crystal structure by adding an ion or cocrystallization partner with known chirality.

Study Programme:

Faculty of Chemical Technology

Photoelectrodes for pollutant removal and hydrogen generation from water using solar light

Krýsa Josef, prof. Dr. Ing. ( kry...@vscht.cz)
Paušová Šárka, Ing. Ph.D. ( Sar...@vscht.cz)
Production of hydrogen as an alternative energy source/carrier is becoming recently very important and intensively studied process. One of the promising options is direct production of hydrogen from water via solar light. Very important process is also removal of persistent pollutants in waters by advanced oxidation processes, one of them is photo-electrochemical oxidation. The topic of the present thesis is the preparation of semiconductor photoanodes and photocathodes (eg. WO3, BiVO4, CuO, CuFeO2, atd.) for photo-electrochemical water splitting or photo-electrochemical removal of persistent pollutants. Different methods of preparation (aerosol pyrolysis, spray pyrolysis, etc. ) will be used and the resulting films will be characterised (XRD, GDS, UV-VIS, BET, SEM) and their photo-electrochemical properties (open circuit potential, photocurrent, IPCE) evaluated. The attention will be given to the influence of composition, crystalline phase, layer thickness and porosity. The best photoanode and photocathode layers will be applied in the tandem solar photo-electrochemical cell and its efficiency for water decomposition to hydrogen and oxygen by sunlight will be determined.
Faculty of Chemical Technology

Photoelectrodes for pollutant removal and hydrogen generation from water using solar light

Krýsa Josef, prof. Dr. Ing. ( kry...@vscht.cz)
Paušová Šárka, Ing. Ph.D. ( Sar...@vscht.cz)
Production of hydrogen as an alternative energy source/carrier is becoming recently very important and intensively studied process. One of the promising options is direct production of hydrogen from water via solar light. Very important process is also removal of persistent pollutants in waters by advanced oxidation processes, one of them is photo-electrochemical oxidation. The topic of the present thesis is the preparation of semiconductor photoanodes and photocathodes (eg. WO3, BiVO4, CuO, CuFeO2, atd.) for photo-electrochemical water splitting or photo-electrochemical removal of persistent pollutants. Different methods of preparation (aerosol pyrolysis, spray pyrolysis, etc. ) will be used and the resulting films will be characterised (XRD, GDS, UV-VIS, BET, SEM) and their photo-electrochemical properties (open circuit potential, photocurrent, IPCE) evaluated. The attention will be given to the influence of composition, crystalline phase, layer thickness and porosity. The best photoanode and photocathode layers will be applied in the tandem solar photo-electrochemical cell and its efficiency for water decomposition to hydrogen and oxygen by sunlight will be determined.
Faculty of Chemical Technology

Photoelectrochemical systems for conversion of solar light

Krýsa Josef, prof. Dr. Ing. ( kry...@vscht.cz)
Neumann-Spallart Michael, Ing. Ph.D.
A photoelectric chemical system involving a photoanode, photocathode, membrane and suitable ox/red couple allows the conversion of solar energy into chemical energy. The theme of this thesis is the investigation of possible systems for solar energy conversion with a focus on suitable photoanode and photocathode materials and their combination with suitable electrolytes. Part of the work will be the preparation of selected photoanode or photocathode materials (e.g. Fe2O3, ZnO, WO3, BiVO4, CuO, CuFeO2, etc.) and investigation of their behaviour during long-term photoelectric polarization.
Different methods of preparation (aerosol pyrolysis, spray pyrolysis, etc. ) will be used and the resulting films will be characterised (XRD, GDS, UV-VIS, BET, SEM) and their photo-electrochemical properties (open circuit potential, photocurrent, IPCE) evaluated. The attention will be given to the influence of composition, doping, crystalline phase, layer thickness and porosity.
Faculty of Chemical Technology

Photoelectrochemical systems for conversion of solar light

Krýsa Josef, prof. Dr. Ing. ( kry...@vscht.cz)
Neumann-Spallart Michael, Ing. Ph.D.
A photoelectric chemical system involving a photoanode, photocathode, membrane and suitable ox/red couple allows the conversion of solar energy into chemical energy. The theme of this thesis is the investigation of possible systems for solar energy conversion with a focus on suitable photoanode and photocathode materials and their combination with suitable electrolytes. Part of the work will be the preparation of selected photoanode or photocathode materials (e.g. Fe2O3, ZnO, WO3, BiVO4, CuO, CuFeO2, etc.) and investigation of their behaviour during long-term photoelectric polarization.
Different methods of preparation (aerosol pyrolysis, spray pyrolysis, etc. ) will be used and the resulting films will be characterised (XRD, GDS, UV-VIS, BET, SEM) and their photo-electrochemical properties (open circuit potential, photocurrent, IPCE) evaluated. The attention will be given to the influence of composition, doping, crystalline phase, layer thickness and porosity.
Faculty of Chemical Engineering

Photochemical processes in astrochemistry

Slavíček Petr, prof. RNDr. Ph.D. ( pet...@vscht.cz)
The Thesis will focus on processes initiated by light in various astrochemically relevant molecules and system. In particular, the applicant will study ice particles and the role of high-energy radiation in astrochemistry. For more information, see http://photox.vscht.cz.
Faculty of Chemical Technology

Photochemistry on the base of noble metals nanostructures

Lyutakov Oleksiy, Mgr. Ph.D. ( ole...@vscht.cz)
Faculty of Food and Biochemical Technology

Physico-chemical properties and biological activities of chocolate and confectionery with a fortified formulation

Čopíková Jana, prof. Ing. CSc. ( cop...@vscht.cz)
Sinica Andrej, doc. Mgr. Ph.D. ( sin...@vscht.cz)
The effect of value-added materials on the physico-chemical properties and biological activity will be monitored on model samples of chocolate and selected confectionery. Wood-decay mushrooms and medicinal herbs or their extracts will be used to fortify chocolate and selected confectionery. The aim of the work will be to verify, in particular, the extent to which the technological behavior of fortified materials changes using rheology, differential scanning calorimetry and X-ray diffraction. At the same time, the biological activities of fortified products will be monitored using adequate approaches.
Faculty of Food and Biochemical Technology

Physiologically beneficial substances formed de novo during food processing

Cejpek Karel, doc. Dr. Ing. ( cej...@vscht.cz)
The subject are physiologically desirable substances formed by complex non-enzymatic browning reactions during food processing. The research is focused on the products contributing to increased redox stability and decreased levels of oxidative stress-inducing carbonyl compounds, in both food and human body. The goal is finding the optimum conditions for the formation of these protective substances in processed foods and designing a procedure for the production of functional foods by the addition of suitable precursors before processing.
Faculty of Food and Biochemical Technology

Physiologically beneficial substances formed de novo during food processing

Cejpek Karel, doc. Dr. Ing. ( cej...@vscht.cz)
The subject are physiologically desirable substances formed by complex non-enzymatic browning reactions during food processing. The research is focused on the products contributing to increased redox stability and decreased levels of oxidative stress-inducing carbonyl compounds, in both food and human body. The goal is finding the optimum conditions for the formation of these protective substances in processed foods and designing a procedure for the production of functional foods by the addition of suitable precursors before processing.
Faculty of Chemical Technology

Plasmon- and electro-chemical active materials for relevant chemical transformations

Lyutakov Oleksiy, Mgr. Ph.D. ( ole...@vscht.cz)
Faculty of Chemical Technology

Polyamide nanocomposites

Brožek Jiří, prof. Ing. CSc. ( bro...@vscht.cz)
The work is focused on the preparation and characterization of novel hybrid materials based on layered inorganic fillers (layered silicate, double hydroxide and graphene) and polyamide 6. These materials will be prepared by in situ polymerization of hexano-6-lactam in the presence of fillers or by melt blending of components.
Faculty of Chemical Technology

Polymer electrolytes for energy conversion devices

Hnát Jaromír, Ing. Ph.D. ( h...@vscht.cz)
Polymer ion selective materials are well established in the many technologies including the environment protection, food industry and large scale production of the basic chemical substances. Energy conversion devices represent the recent but sharply growing field of the ion selective membrane utilization. The work is focused on the complex characterisation of the physio-chemical and electrochemical properties of the developmental ion selective polymer electrolytes.
Faculty of Chemical Technology

Polymer electrolytes for energy conversion devices

Hnát Jaromír, Ing. Ph.D. ( h...@vscht.cz)
Polymer ion selective materials are well established in the many technologies including the environment protection, food industry and large scale production of the basic chemical substances. Energy conversion devices represent the recent but sharply growing field of the ion selective membrane utilization. The work is focused on the complex characterisation of the physio-chemical and electrochemical properties of the developmental ion selective polymer electrolytes.
Faculty of Chemical Technology

Polymer materials for industrial 3D printing

Kuta Antonín, doc. Ing. CSc. ( k...@vscht.cz)
Faculty of Food and Biochemical Technology

Polysaccharides of wood decay mushrooms: isolation, structure and biological activities

Sinica Andrej, doc. Mgr. Ph.D. ( sin...@vscht.cz)
Bleha Roman, Ing. Ph.D. ( ble...@vscht.cz)
The wood decay fungi are potential sources of biologically active compounds such as secondary metabolites: proteins, structural polysaccharides, terpenoids, polyphenols, etc. This dissertation will be focused on isolation and structural characterization of biologically active metabolites by spectroscopic, chromatographic and separation methods. Antioxidant, antitumor, immunomodulatory activities of selected compounds will be tested in cooperation with the Department of Biochemistry and Microbiology at University of Chemistry and Technology Prague.
Faculty of Chemical Engineering

Porous catalytic layers in structured reactors

Kočí Petr, doc. Ing. Ph.D. ( pet...@vscht.cz)
The work focuses on preparation and coating of porous catalytic layers in structured reactors such as honeycomb monoliths, filters, porous membranes and open foams. The aim is to intensify the reactor operation with respect to utilization of the catalytic material and mass and heat tranfer. Industrially relevant processes such as exhaust gas conversion, partial oxidation and reforming of methane will be studied. Morphology of the samples will be analyzed by electron microscopy (SEM, TEM) and X-ray tomography (XRT). Impact of the microstructure on the overall performance of the device will be tested in a lab reactor. The topic is supported by the leading catalyst manufacturer Johnson Matthey.
Faculty of Chemical Engineering

Porous catalytic layers in structured reactors

Kočí Petr, doc. Ing. Ph.D. ( pet...@vscht.cz)
The work focuses on preparation and coating of porous catalytic layers in structured reactors such as honeycomb monoliths, filters, porous membranes and open foams. The aim is to intensify the reactor operation with respect to utilization of the catalytic material and mass and heat tranfer. Industrially relevant processes such as exhaust gas conversion, partial oxidation and reforming of methane will be studied. Morphology of the samples will be analyzed by electron microscopy (SEM, TEM) and X-ray tomography (XRT). Impact of the microstructure on the overall performance of the device will be tested in a lab reactor. The topic is supported by the leading catalyst manufacturer Johnson Matthey.
Faculty of Environmental Technology

Possibilities of using advanced simulation tools for the design and control of innovative decontamination technologies

Kubal Martin, doc. Dr. Ing. ( kub...@vscht.cz)
Škarohlíd Radek, Ing. ( Rad...@vscht.cz)
Faculty of Environmental Technology

Possibilities of utilization of diamond electrodes in the wastewater treatment

Wanner Jiří, prof. Ing. DrSc. ( wan...@vscht.cz)
Srb Martin, Ing. Ph.D. ( mar...@pvk.cz)
The aim of study is utilization of advanced oxidation processes and conductive diamond electrodes for removal of micropollutants and biologically active substances in wastewater. Research of electrochemical methods used for wastewater treatment and testing of these methods for selected types of pollutants in laboratory conditions will be the basis for design, implementation and optimization of a pilot plant using a cleaning cell with diamond electrode for field testing at a real WWTP.
Faculty of Chemical Technology

Precipitation of calcium phosphates during interaction of biomaterials with simulated body fluids

Helebrant Aleš, prof. Ing. CSc. ( hel...@vscht.cz)
The study will be oriented on precipitation of calcium phosphates from selected simulated body fluids. The aim is to experimentaly measure the kinetics of phosphates precipitation and describe it using chosen or newly developed physico-chemical models
Faculty of Chemical Technology

Prediction and experimental determination of transport properties of mixed-matrix membranes

Čapek Pavel, doc. Ing. CSc. ( cap...@vscht.cz)
The work is aimed at simulation and experimental determination of transport properties of mixed-matrix membranes that differ from each other in polymer and filler materials. In addition, the membranes containing different fractions of filler particles will be investigated. Statistical treatment of obtained data will accompany the experimental determination of permeability. Permeability will also be modelled on the basis of reconstructed microstructures of the membranes and transport properties of components forming the membranes.
Faculty of Chemical Engineering

Preferential interactions of osmolytes with soft matter

Heyda Jan, RNDr. Mgr. Ph.D. ( jan...@vscht.cz)
Protein stability and association, membrane formation, solubility of chemically heterogeneous drugs and their partitioning between inner and outer cell environment are theoretically simple to describe, but in reality complex processes, which play an essential role in soft matter. These processes can be seen as results of competition of several driving forces [Dill]. More commonly, these forces compensate each other and are very finely balance at system equilibrium. Another approach to insight, and subsequent control of these processes employs the perturbation of the natural environment by the addition of cosolvents. These interactions might be net-attractive or net-repulsive, leading to enrichment or depletion of the additive in solute vicinity. However, the manifestation is different for small (osmotic properties) and large solutes (dialysis, partitioning), thus to obtain a generic view is rather challenging.
In this thesis, the candidate will research the changes in chemical potential of various solutes in the presence of osmolytes and the implications on the solute state, i.e., conformation or phase [Heyda, Chudoba]. The investigation thus cover systems form single small molecules to monomer and similar polymer, up to macromolecular complexes, which naturally require employment of whole ensemble of theoretical approaches. On the simulation side, all-atom molecular dynamics simulations will be complemented by implicit solvent coarse-grained models [Chudoba, Roux]. Monte-Carlo simulations will be used for investigation of phase equilibria employing highly coarse-grained models. Simulation data will be complemented by statistical thermodynamic framework [Smith, Smith1], with the long term aim of derivation theory-based equations of state.
Faculty of Chemical Technology

Preparation and crystal growth of scintillating materials based on alkali halides and study of new doping concepts

Rubešová Kateřina, doc. Ing. Ph.D. ( kat...@vscht.cz)
The topic of this work will be focused on the preparation and crystal growth of scintillating materials based on hygroscopic alkali halides, e.g. sodium iodide (NaI), cesium iodide (CsI), doped with monovalent cations (e.g. Tl), by vertical Bridgman and micro-pulling-down methods. The work will be performed in collaboration with the company NUVIA a.s. and Physical Institute, ASCR. The study will aim on the optimization of the growth technology of bulk NaI:Tl single crystals prepared by the vertical Bridgman method and on the study of new co-doping concepts in alkali halides (NaI:Tl) by cations of higher valence state, e.g. Sr, Ca, Eu2+. The composition (elemental and phase) of prepared materials and their crystals as well as the thermal, optical, luminescence, and scintillation properties will be studied. The goal of this work is to improve the optical quality of prepared crystals (for industrial applications), the optimization of the crysta