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PhD topics for academic year 2021/2022

Department of Informatics and Chemistry

Bioinformatics

Faculty of Chemical Technology

Does the lack of sex affect our genomes and phenotypes? The impact of asexual reproduction on genomes, populations and fitness of clonal individuals.

Pačes Jan, Mgr. Ph.D. ( hpa...@img.cas.cz)
Development principles: V rámci projektu se student zapojí do mezinárodního teamu zaměřeného na výzkum klonálně se množících obratlovců.Cílem bude zjistit, jaký má klonování, tj. tvorba gamet bez klasické segregace a rekombinace, vliv na strukturu genomu a na fenotyp. V rámci terénní části práce pak bude student zkoumat typy prostředí, ve kterých se klonální jedinci uplatňují lépe, či hůře, než sexuálně se množící populace. Tato unikátní kombinace genotypových, fenotypových a ekologických dat nám umožní analyzovat podmínky, za kterých se patrně vyvinulo sexuální rozmnožování, a také zjistit v čem spočívá evoluční výhoda klonality.
In frame of the project, the student will join an international team investigating clonally reproducing vertebrates. He/she will evaluate the effect of cloning, i.e. gamete production without efficient recombination and segregation, on genome structure and phenotypes. During the field part of the project, the student will identify the types of environments where asexual individuals perform better than their sexually reproducing counterparts. Such a unique combination of genotypic, phenotypic and ecological data will enable unprecedented insight into the conditions under which sex might have evolved, and also the evolutionary potential of asexual reproduction.
Faculty of Chemical Technology

Virtual screening in chemical biology

Svozil Daniel, doc. Mgr. Ph.D. ( svo...@vscht.cz)
Chemical biology is a scientific discipline that attempts to answer biological questions by directly probing living systems at the chemical level. The main application area of chemical biology is the development and characterization of organic compounds that are used for the study of various biological systems. The key experimental method used in chemical biology is high-throughput screening (HTS) that enables to quickly assess the biological activity of thousands of compounds at once. Because of its high time and cost demands, it is usually preceded by virtual screening, a computational technique used to search libraries of small molecules in order to identify those compounds which are most likely to bind to a given molecular target. The dissertation is focused on the application of advanced virtual screening methods for the identification of ligands active against various molecular targets (e.g., juvenile hormone receptor) with the aim to gain deeper insight into their biological behavior.
Updated: 11.12.2019 11:36, Author: Jan Kříž

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