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PhD topics for academic year 2021/2022

Department of Biochemistry and Microbiology

Biochemistry and Bioorganic Chemistry

Faculty of Food and Biochemical Technology

Production of antibacterial peptides from marine organisms and evaluation of their biological activity

Ruml Tomáš, prof. Ing. CSc. ( r...@vscht.cz)
Stensvåg Klara, Professor PhD ( kla...@uit.no)
Design of bacterial expression system for production of existing antibacterial peptides identified in the laboratory of prof. Stensvåg at University in Tromso. Firstly, it is necessary to overcome the toxicity issues either by fusion with bulky protein or secretion achieved by fusion of the peptides to export sequence. Next step is upscale to massive production and purification for functional studies (pull down assay with bacterial cell lysate). Isolated products will be used for analysis of biological activity targeted against bacterial and yeast cells, including biofilms and determination of immunomodulatory effects. Subsequently it is planned a study of mechanisms leading to inhibition.
UIT The Arctic University of Norway
Updated: 29.11.2019 12:30, Author: Jan Kříž

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