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PhD topics for academic year 2021/2022

Department of Analytical Chemistry

Analytical and Physical Chemistry

Faculty of Chemical Engineering

Supramolecular assemblies and gels from helicene-polypeptide conjugates: synthesis and chiroptical properties

Setnička Vladimír, prof. Ing. Ph.D. ( set...@vscht.cz)
Crassous Jeanne, dr ( jea...@univ-rennes1.fr)
This work will be focused on the preparation and characterization of new supramolecular systems based on helicene-polypeptide conjugates. The polypeptide moiety will be systematically modified to produce highly ordered supramolecular aggregates stabilized by hydrogen and other interactions. Common methods of structural analysis including highly sensitive methods of chiroptical spectroscopy (electronic circular dichroism ECD, vibrational circular dichroism VCD and Raman optical activity ROA) will be used for the characterization.
École nationale supérieure de chimie de Rennes, France
Faculty of Chemical Engineering

Interpretation of Raman optical activity of nucleic acids

Bouř Petr, prof. RNDr. CSc. ( b...@uochb.cas.cz)
Hopmann Kathrin Helen, Assoc. Prof. Ph.D. ( kat...@uit.no)
Spectroscopy of vibrational Raman optical activity is a new and dynamically evolving analytical method providing important information, such as about biopolymer and enzyme structure. The applications are very dependent on spectral interpretations based on the molecular dynamics and quantum chemical computational methods. For nucleic acids, although experimentally very interesting systems can be approached, including viruses, the relation between the spectrum and the structure is not completely known. A big problem are computer demands required by these complex and big molecules. We will therefore focus on development of experimental and computational methodology for model system, suitable to describe specific nucleic acid properties, such as flexibility and polarity. Modern computational methods will be both used and developed, such as combination of classical and quantum mechanics or testing models of solvent and environment during molecular interactions.
UIT The Arctic University of Norway

Department of Computing and Control Engineering

Analytical and Physical Chemistry

Faculty of Chemical Engineering

Synthesis of biodegradable amphiphilic block copolymers and their application in drug delivery formulation

Hassouna Fatima, doc. Mgr. Ph.D. ( Fat...@vscht.cz)
Fulem Michal, prof. Ing. Ph.D. ( ful...@vscht.cz)
Synthetic biodegradable polymers have attracted substantial attention in the field of drug delivery because of their attractive characteristics such as renewability, biocompatibility, biodegradability and low toxicity. Among various biodegradable polymers, polyesters like polylactide is one of the most used one in the medical field. This project deals with the preparation of PLA based copolymers bearing functional groups. Depending on the desired type of functionalization, appropriate synthetic methods will be applied. These biocompatible copolymers will allow preparing highly miscible drug/polymer delivery systems in a form of amorphous solid dispersions using different approaches.

Department of Physical Chemistry

Analytical and Physical Chemistry

Faculty of Chemical Engineering

New effective separation membranes for water and wastewater treatment based on hybrid carbon-based materials

Friess Karel, doc. Ing. Ph.D. ( fri...@vscht.cz)
Current membrane separation processes allow efficient purification and physical disinfection of water from undesirable components on the basis of a size-sieving mechanism without the need for chemical agents. The pore sizes and their distribution on the membrane surface is an important factor for the effective removal of contaminants and microorganisms. The thesis will study the possibilities of using newly prepared membrane materials based on carbon materials (carbon nanotubes, graphene derivatives, etc.) with targeted surface modifications (eg doping with antimicrobial agents, etc.) in order to effectively remove collected contaminants from water. In addition to the preparation, characterization and testing of materials, the work will also include modelling of the separation process. The result of this work will be, besides the preparation of an effective separation material and describing the model, an extension of knowledge in the given membrane field.
KU Leuven, Belgium
Updated: 29.11.2019 12:30, Author: Jan Kříž

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