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PhD topics for academic year 2021/2022

Department of Analytical Chemistry

Analytical and Physical Chemistry

Faculty of Chemical Engineering

Interpretation of Raman optical activity of nucleic acids

Bouř Petr, prof. RNDr. CSc. ( b...@uochb.cas.cz)
Hopmann Kathrin Helen, Assoc. Prof. Ph.D. ( kat...@uit.no)
Spectroscopy of vibrational Raman optical activity is a new and dynamically evolving analytical method providing important information, such as about biopolymer and enzyme structure. The applications are very dependent on spectral interpretations based on the molecular dynamics and quantum chemical computational methods. For nucleic acids, although experimentally very interesting systems can be approached, including viruses, the relation between the spectrum and the structure is not completely known. A big problem are computer demands required by these complex and big molecules. We will therefore focus on development of experimental and computational methodology for model system, suitable to describe specific nucleic acid properties, such as flexibility and polarity. Modern computational methods will be both used and developed, such as combination of classical and quantum mechanics or testing models of solvent and environment during molecular interactions.
UIT The Arctic University of Norway

Department of Biochemistry and Microbiology

Biochemistry and Bioorganic Chemistry

Faculty of Food and Biochemical Technology

Production of antibacterial peptides from marine organisms and evaluation of their biological activity

Ruml Tomáš, prof. Ing. CSc. ( r...@vscht.cz)
Stensvåg Klara, Professor PhD ( kla...@uit.no)
Design of bacterial expression system for production of existing antibacterial peptides identified in the laboratory of prof. Stensvåg at University in Tromso. Firstly, it is necessary to overcome the toxicity issues either by fusion with bulky protein or secretion achieved by fusion of the peptides to export sequence. Next step is upscale to massive production and purification for functional studies (pull down assay with bacterial cell lysate). Isolated products will be used for analysis of biological activity targeted against bacterial and yeast cells, including biofilms and determination of immunomodulatory effects. Subsequently it is planned a study of mechanisms leading to inhibition.
UIT The Arctic University of Norway
Updated: 29.11.2019 12:30, Author: Jan Kříž

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