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Department of Analytical Chemistry

List of available PhD theses

Interpretation of Raman optical activity of nucleic acids

Department: Department of Analytical Chemistry, Faculty of Chemical Engineering
Study programme: Chemie (double degree)
Theses supervisor: prof. RNDr. Petr Bouř, CSc.

Annotation

Spectroscopy of vibrational Raman optical activity is a new and dynamically evolving analytical method providing important information, such as about biopolymer and enzyme structure. The applications are very dependent on spectral interpretations based on the molecular dynamics and quantum chemical computational methods. For nucleic acids, although experimentally very interesting systems can be approached, including viruses, the relation between the spectrum and the structure is not completely known. A big problem are computer demands required by these complex and big molecules. We will therefore focus on development of experimental and computational methodology for model system, suitable to describe specific nucleic acid properties, such as flexibility and polarity. Modern computational methods will be both used and developed, such as combination of classical and quantum mechanics or testing models of solvent and environment during molecular interactions.

Supramolecular assemblies and gels from helicene-polypeptide conjugates: synthesis and chiroptical properties

Department: Department of Analytical Chemistry, Faculty of Chemical Engineering
Study programme: Chemie (double degree)

Annotation

This work will be focused on the preparation and characterization of new supramolecular systems based on helicene-polypeptide conjugates. The polypeptide moiety will be systematically modified to produce highly ordered supramolecular aggregates stabilized by hydrogen and other interactions. Common methods of structural analysis including highly sensitive methods of chiroptical spectroscopy (electronic circular dichroism ECD, vibrational circular dichroism VCD and Raman optical activity ROA) will be used for the characterization.

Updated: 18.2.2020 13:59, Author: Jan Kříž

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